Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6774

Name

STAT3

Synonymous

APRF|HIES;signal transducer and activator of transcription 3 (acute-phase response factor);STAT3;signal transducer and activator of transcription 3 (acute-phase response factor)

Definition

DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3

Position

17q21.31

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr17:40465342-40540586chr17:40499533-40499533rs6503695Single_Nucleotides|eQTL|KAT2A, Single_Nucleotides|eQTL|MLX, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|FAIRE|A549, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|FAIRE|Nhek, Chromatin_Structure|DNase-seq|Panislets, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|FAIRE|Htr8, Chromatin_Structure|DNase-seq|Melano, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA3, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|FOS, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|JUN
chr17:40465342-40540586chr17:40510534-40510534rs9912773Single_Nucleotides|eQTL|MLX, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|FAIRE|Gm19239

Transcription Factors   [Top]

Regulation From TransFac database

AR(h) + STAT3(h) <==> AR(h):STAT3(h) (binding)
PKR(h) + STAT3(h) <==> PKR(h):STAT3(h) (binding)
STAT3(h) --> IRF1(h) (DNA binding).
p21Cip1(h) + STAT3(h) <==> p21Cip1(h):STAT3(h) (binding)
STAT3(h) --> CDKN1A(h) (DNA binding; transactivation).
STAT3(h) + ATP --protein tyrosine kinases(v.s.)--> STAT3(h){pY705} + ADP (phosphorylation)
STAT3(h) + ATP --protein tyrosine kinases(v.s.)--> STAT3(h){pY} + ADP (phosphorylation)
IL-13Ralpha1(h){pY} + STAT3(h) <==> IL-13Ralpha1(h){pY}:STAT3(h) (binding)
TFII-I(h) + STAT3(h) <==> TFII-I(h):STAT3(h) (binding)
STAT3(h) --> Stat3(m) (DNA binding; transactivation).
STAT1(h) + STAT3(h) <==> STAT1(h):STAT3(h) (binding)
2 STAT3(h) <==> STAT3(h):STAT3(h) (binding)
Fes(h) + STAT3(h) <==> Fes(h):STAT3(h) (binding)
STAT3(h) --> c-myc(h) (DNA binding; transactivation).
STAT3(h) --> IL10(h) (DNA binding).
ErbB1(h) + STAT3(h) <==> ErbB1(h):STAT3(h) (binding)
Pyk2-isoform1(h) + STAT3(h) <==> Pyk2-isoform1(h):STAT3(h) (binding)
STAT3(h) --> FOS(h) (DNA binding; transactivation).
STAT3(h) --> Trh(m) (DNA binding; transactivation).
STAT3(h) --> Fos(m) (DNA binding; transactivation).
STAT3(h) --> TRH(h) (DNA binding; transactivation).
STAT3(h) --> IL-2Ralpha(h) (DNA binding; transactivation).
STAT3(h) --> PIM1(h) (DNA binding; transactivation).
STAT3(h) + c-Jun(h) <==> STAT3(h):c-Jun(h) (binding) [re.
STAT3(h) + IRAK1(h) <==> STAT3(h):IRAK1(h) (binding)
STAT3(h) + ATP --> STAT3(h){pY705} + ADP (phosphorylation)
STAT3(h) + ATP --> STAT3(h){p} + ADP (phosphorylation)
STAT3(h) + MNAR(h) <==> STAT3(h):MNAR(h) (binding)
STAT3(h) --> STAT3(h) (translocation)
caveolin-1(h) + STAT3(h) <==> caveolin-1(h):STAT3(h) (binding)
Hsp90(h) + caveolin-1(h) + STAT3(h) <==> Hsp90(h):caveolin-1(h):STAT3(h) (binding)
GRP58(h) + Hsp90(h) + STAT1(h) + caveolin-1(h) + STAT3(h) <==> GRP58(h):Hsp90(h):STAT1(h):caveolin-1(h):STAT3(h) (binding)
STAT3(h) + ATP --> STAT3(h){pY} + ADP (phosphorylation)
STAT3(h) --> Mt1(m) (DNA binding).
STAT3(h) --> OPRM1(h) (DNA binding).
ErbB1-p170(h){pY1016} + STAT3(h) <==> ErbB1-p170(h){pY1016}:STAT3(h) (binding)
ErbB2(h){pY1023}{pY1222} + STAT3(h) <==> ErbB2(h){pY1023}{pY1222}:STAT3(h) (binding)
ErbB3-isoform1(h) + STAT3(h) <==> ErbB3-isoform1(h):STAT3(h) (binding)
ErbB4(h) + STAT3(h) <==> ErbB4(h):STAT3(h) (binding)
STAT3(h) --> VIP(h) (DNA binding).
STAT3(h) + ATP --> STAT3(h){pS727} + ADP (phosphorylation)
STAT3(h) --Caspase(h)--> protein remnants (cleavage)
STAT3(h) + ErbB1(h){p} <==> STAT3(h):ErbB1(h){p} (binding)
Src(h) + STAT3(h) <==> Src(h):STAT3(h) (binding)
STAT3(h) --> IL6ST(h) (DNA binding; transactivation).
PECAM-1(h) + STAT3(h) <==> PECAM-1(h):STAT3(h) (binding)
lepr-B(m){pY1138} + STAT3(h) <==> lepr-B(m){pY1138}:STAT3(h) (binding)
lepr-B(m){pY985} + STAT3(h) <==> lepr-B(m){pY985}:STAT3(h) (binding)
STAT3(h) --> BIRC5(h) (DNA binding).
STAT3(h) --> TWIST1(h) (DNA binding).
STAT3(h) + 2 ATP --> STAT3(h){pY705}{pS727} + 2 ADP (phosphorylation)
STAT3(h) + p300(h) <==> STAT3(h):p300(h) (binding)
STAT3(h) --> FGG(h) (transactivation)
STAT3(h) --> Socs3(m) (transactivation)
STAT3(h) --> Fos(m) (transactivation)
STAT3(h) --> CDKN1A(m) (transactivation)
STAT3(h) + ZIPK(h) <==> STAT3(h):ZIPK(h) (binding)
STAT3(h) + nanog(h) <==> STAT3(h):nanog(h) (binding)
STAT3(h) --> ABCB1(h) (transactivation)
STAT3(h) --> IFNG(h) (DNA binding).
STAT3(h) --> MYD88(h) (DNA binding).
STAT3(h) --> IL21(h) (DNA binding).
STAT3(h) --> CISH(h) (DNA binding).
STAT3(h) --> STAT3(h) (translocation)
ARHI(h) + STAT3(h) <==> ARHI(h):STAT3(h) (binding)
ARHI(h) + STAT3(h) <==> ARHI(h):STAT3(h) (binding)
STAT3(h) --> IL8(h) (transactivation)
STAT3(h) --> CCR5(h) (DNA binding).
STAT3(h) --> CD274(h) (DNA binding).
STAT3(h) --> REG1A(h) (DNA binding).
STAT3(h) --> ICAM1(h) (DNA binding).
STAT3(h) --> FCGR1C(h) (DNA binding).
STAT3(h) + IL-22R1(h) <==> STAT3(h):IL-22R1(h) (binding)
STAT3(h) --> MMP1(h) (DNA binding).
STAT3(h) --> c-myc(m) (DNA binding).
STAT3(h) --> VIM(h) (DNA binding).
STAT3(h) --> CYP19A1(h) (DNA binding).
STAT3(h) --> VEGFA(h) (DNA binding).
STAT3(h) --> TIMP-1(r) (DNA binding).
STAT3(h) --> SPI-3(r) (DNA binding).
STAT3(h) --> NOS3(h) (DNA binding).
STAT3(h) --> AGT(h) (DNA binding).
STAT3(h) --> PRF1(h) (DNA binding).
STAT3(h) --> Mcl1(m) (DNA binding).
STAT3(h) --> FAAH(h) (DNA binding).
STAT3(h) + acetyl-CoA --p300(m.s.)--> STAT3(h){aceK685} + CoA (acetylation)
STAT3(h) + acetyl-CoA --> STAT3(h){aceK685} + CoA (acetylation)
STAT3(h) + gp130(h) <==> STAT3(h):gp130(h) (binding)
STAT3(h) --> JUNB(h) (transactivation)
STAT3(h) --> ZFP36(h) (transactivation)
SRC-1(h) + STAT3(h) <==> SRC-1(h):STAT3(h) (binding)
IL-22(h) --> STAT3(h) (activation; phosphorylation)
IL-17A(h) --> STAT3(h) (activation; phosphorylation)
STAT3(h) --> STAT3(h) (expression).
STAT3(h) --> STAT3(h) (translocation)
STAT3(h) --> STAT3(h) (translocation)
STAT3(h){pY} --PTP1B(h)--> STAT3(h) + p (dephosphorylation)
STAT3(h){pY} --MEG2(h)--> STAT3(h) + p (dephosphorylation)
IFN-lambda(m.s.) --> STAT3(h) (increase of abundance)
IFNalpha(m) --> STAT3(h) (increase of abundance)
STAT3-isoform1(h) --> A2-Mag(r) (DNA binding).
STAT3-isoform1(h) --> CRP(h) (DNA binding; transactivation).
STAT3-isoform1(h) --/ GLOB-AG(h) (DNA binding; transrepression).
STAT3-isoform1(h) --> MUC1(h) (DNA binding; transactivation).
STAT3-isoform1(h) --> HGF(h) (DNA binding; transactivation).
STAT3-isoform1(h) + HDAC1(h) <==> STAT3-isoform1(h):HDAC1(h) (binding)
STAT3-isoform1(h) --Caspase(h)--> STAT3-isoform1-p43(h) + protein remnants (cleavage)
STAT3-isoform1(h) --Caspase(h)--> STAT3-isoform1-p48(h) + protein remnants (cleavage)
STAT3-isoform1(h) + ATP --> STAT3-isoform1(h){pY705} + ADP (phosphorylation)
STAT3-isoform1(h) + 2 ATP --> STAT3-isoform1(h){pY705}{pS727} + 2 ADP (phosphorylation)
SRC-1A(h) + STAT3-isoform1(h) <==> SRC-1A(h):STAT3-isoform1(h) (binding)
STAT3(h) --> STAT3-isoform1(h) (expression).
EGF(m.s.) --> STAT3-isoform1(h) (increase of abundance)
STAT3(h) --> STAT3-isoform2(h) (expression).
STAT3(h) --> STAT3_01(h) (expression).
hsa-miR-124a --/ STAT3_01(h) (predicted)
STAT3(h) --> STAT3_02(h) (expression).
hsa-miR-124a --/ STAT3_02(h) (predicted)
STAT3(h) --> STAT3_03(h) (expression).
hsa-miR-124a --/ STAT3_03(h) (predicted)
STAT3-isoform3(h) --> AKT1(h) (DNA binding).
STAT3(h) --> STAT3-isoform3(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

705Phosphotyrosine.Swiss-Prot 53.0
727Phosphoserine (By similarity).Swiss-Prot 53.0
705Phosphotyrosine (ALK;Src;JAK1)9083098;11429593;9582023;15592455;12244095;1455121Phospho.ELM 6.0
727Phosphoserine (MAPKAPK2;IRA)14551213;15465816Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr17

 Promoter: 37793539 - 37795539Agilent_014791

chr17

 Promoter: 37793431 - 37795431Agilent_014791

chr17

 Promoter: 37793539 - 37795539GSE27584

chr17

 Promoter: 37793431 - 37795431GSE27584

chr17

 Promoter: 37793539 - 37795539GSE27584

chr17

 Promoter: 37793539 - 37795539Agilent_014791_44K

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