| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7010 |
Name | TEK |
Synonym | CD202B|TIE-2|TIE2|VMCM|VMCM1;TEK tyrosine kinase, endothelial;TEK;TEK tyrosine kinase, endothelial |
Definition | angiopoietin-1 receptor|endothelial tyrosine kinase|hTIE2|p140 TEK|soluble TIE2 variant 1|soluble TIE2 variant 2|tunica interna endothelial cell kinase|tyrosine kinase with Ig and EGF homology domains-2|tyrosine-protein kinase receptor TEK|tyrosine-protei |
Position | 9p21 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. |
PAH | Angiopoietin/Tie2 pathway influences smooth muscle hyperplasia in idiopathic pulmonary hypertension. |
PAH | "Since both Ang-1/Tie2 and VEGF promote angiogenesis and vascular survival, and play protective roles in the adaptation of microvascular changes during the onset of PH, the downregulation of both Ang-1/Tie2 and VEGF and upregulation of Ang-3 appear to be associated with vascular rarefaction and the development of hypoxic PH." |
PAH | Downregulation of angiopoietin-1 and Tie2 in chronic hypoxic pulmonary hypertension. |
PAH | Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension. |
PAH | Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization. |
| More detail of all Rat literatures about TEK | |
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Pathways and Diseases |
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Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Tie2 Signaling;PID Reactome;500306 |
Pathway | Angiogenesis;PANTHER;P00005 |
Disease | smoking cessation;GAD |
Disease | CHEMDEPENDENCY;GAD |
Disease | Venous malformations, multiple cutaneous and mucosal;OMIM |
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External Links |
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Links to Entrez Gene | 7010 |
Links to all GeneRIF Items | 7010 |
Links to iHOP | 7010 |
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Sequence Information |
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Nucleotide Sequence |
>7010 : length: 3375 atggactctttagccagcttagttctctgtggagtcagcttgctcctttctggaactgtg gaaggtgccatggacttgatcttgatcaattccctacctcttgtatctgatgctgaaaca tctctcacctgcattgcctctgggtggcgcccccatgagcccatcaccataggaagggac tttgaagccttaatgaaccagcaccaggatccgctggaagttactcaagatgtgaccaga gaatgggctaaaaaagttgtttggaagagagaaaaggctagtaagatcaatggtgcttat ttctgtgaagggcgagttcgaggagaggcaatcaggatacgaaccatgaagatgcgtcaa caagcttccttcctaccagctactttaactatgactgtggacaagggagataacgtgaac atatctttcaaaaaggtattgattaaagaagaagatgcagtgatttacaaaaatggttcc ttcatccattcagtgccccggcatgaagtacctgatattctagaagtacacctgcctcat gctcagccccaggatgctggagtgtactcggccaggtatataggaggaaacctcttcacc tcggccttcaccaggctgatagtccggagatgtgaagcccagaagtggggacctgaatgc aaccatctctgtactgcttgtatgaacaatggtgtctgccatgaagatactggagaatgc atttgccctcctgggtttatgggaaggacgtgtgagaaggcttgtgaactgcacacgttt ggcagaacttgtaaagaaaggtgcagtggacaagagggatgcaagtcttatgtgttctgt ctccctgacccctatgggtgttcctgtgccacaggctggaagggtctgcagtgcaatgaa gcatgccaccctggtttttacgggccagattgtaagcttaggtgcagctgcaacaatggg gagatgtgtgatcgcttccaaggatgtctctgctctccaggatggcaggggctccagtgt gagagagaaggcataccgaggatgaccccaaagatagtggatttgccagatcatatagaa gtaaacagtggtaaatttaatcccatttgcaaagcttctggctggccgctacctactaat gaagaaatgaccctggtgaagccggatgggacagtgctccatccaaaagactttaaccat acggatcatttctcagtagccatattcaccatccaccggatcctcccccctgactcagga gtttgggtctgcagtgtgaacacagtggctgggatggtggaaaagcccttcaacatttct gttaaagttcttccaaagcccctgaatgccccaaacgtgattgacactggacataacttt gctgtcatcaacatcagctctgagccttactttggggatggaccaatcaaatccaagaag cttctatacaaacccgttaatcactatgaggcttggcaacatattcaagtgacaaatgag attgttacactcaactatttggaacctcggacagaatatgaactctgtgtgcaactggtc cgtcgtggagagggtggggaagggcatcctggacctgtgagacgcttcacaacagcttct atcggactccctcctccaagaggtctaaatctcctgcctaaaagtcagaccactctaaat ttgacctggcaaccaatatttccaagctcggaagatgacttttatgttgaagtggagaga aggtctgtgcaaaaaagtgatcagcagaatattaaagttccaggcaacttgacttcggtg ctacttaacaacttacatcccagggagcagtacgtggtccgagctagagtcaacaccaag gcccagggggaatggagtgaagatctcactgcttggacccttagtgacattcttcctcct caaccagaaaacatcaagatttccaacattacacactcctcagctgtgatttcttggaca atattggatggctattctatttcttctattactatccgttacaaggttcaaggcaagaat gaagaccagcacgttgatgtgaagataaagaatgccaccatcactcagtatcagctcaag ggcctagagcctgaaacagcataccaggtggacatttttgcagagaacaacatagggtca agcaacccagccttttctcatgaactggtgaccctcccagaatctcaagcaccagcggac ctcggaggggggaagatgctgcttatagccatccttggctctgctggaatgacctgcctg actgtgctgttggcctttctgatcatattgcaattgaagagggcaaatgtgcaaaggaga atggcccaagccttccaaaacgtgagggaagaaccagctgtgcagttcaactcagggact ctggccctaaacaggaaggtcaaaaacaacccagatcctacaatttatccagtgcttgac tggaatgacatcaaatttcaagatgtgattggggagggcaattttggccaagttcttaag gcgcgcatcaagaaggatgggttacggatggatgctgccatcaaaagaatgaaagaatat gcctccaaagatgatcacagggactttgcaggagaactggaagttctttgtaaacttgga caccatccaaacatcatcaatctcttaggagcatgtgaacatcgaggctacttgtacctg gccattgagtacgcgccccatggaaaccttctggacttccttcgcaagagccgtgtgctg gagacggacccagcatttgccattgccaatagcaccgcgtccacactgtcctcccagcag ctccttcacttcgctgccgacgtggcccggggcatggactacttgagccaaaaacagttt atccacagggatctggctgccagaaacattttagttggtgaaaactatgtggcaaaaata gcagattttggattgtcccgaggtcaagaggtgtatgtgaaaaagacaatgggaaggctc ccagtgcgctggatggccatcgagtcactgaattacagtgtgtacacaaccaacagtgat gtatggtcctatggtgtgttactatgggagattgttagcttaggaggcacaccctactgc gggatgacttgtgcagaactctacgagaagctgccccagggctacagactggagaagccc ctgaactgtgatgatgaggtgtatgatctaatgagacaatgctggcgggagaagccttat gagaggccatcatttgcccagatattggtgtccttaaacagaatgttagaggagcgaaag acctacgtgaataccacgctttatgagaagtttacttatgcaggaattgactgttctgct gaagaagcggcctag |
Protein Sequence |
>7010 : length: 1124 MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTCIASGWRPHEPITIGRD FEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKMRQ QASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVHLPH AQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTACMNNGVCHEDTGEC ICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYGCSCATGWKGLQCNE ACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIPRMTPKIVDLPDHIE VNSGKFNPICKASGWPLPTNEEMTLVKPDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSG VWVCSVNTVAGMVEKPFNISVKVLPKPLNAPNVIDTGHNFAVINISSEPYFGDGPIKSKK LLYKPVNHYEAWQHIQVTNEIVTLNYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTAS IGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSV LLNNLHPREQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWT ILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQLKGLEPETAYQVDIFAENNIGS SNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRR MAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLK ARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYL AIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQF IHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSD VWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA |