| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 7010 |
Name | TEK |
Synonymous | CD202B|TIE-2|TIE2|VMCM|VMCM1;TEK tyrosine kinase, endothelial;TEK;TEK tyrosine kinase, endothelial |
Definition | angiopoietin-1 receptor|endothelial tyrosine kinase|hTIE2|p140 TEK|soluble TIE2 variant 1|soluble TIE2 variant 2|tunica interna endothelial cell kinase|tyrosine kinase with Ig and EGF homology domains-2|tyrosine-protein kinase receptor TEK|tyrosine-protei |
Position | 9p21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
|
Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr9:27109139-27230173 | chr9:27135962-27135962 | rs7042267 | Single_Nucleotides|eQTL|HSPC065, Chromatin_Structure|DNase-seq|Hvmf | chr9:27109139-27230173 | chr9:27196119-27196119 | rs633903 | Single_Nucleotides|eQTL|TEK, Motifs|PWM|Staf, Motifs|PWM|Staf, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hmvecdblad |
|---|---|---|---|
Transcription Factors [Top] |
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Regulation From TransFac database |
ANG2(h) + Tie2(h) <==> ANG2(h):Tie2(h) (binding) | Tie2(h) + ATP --> Tie2(h){pY} + ADP (phosphorylation) | ANG4(m) + Tie2(h) <==> ANG4(m):Tie2(h) (binding) | ANG4(h) + Tie2(h) <==> ANG4(h):Tie2(h) (binding) | TEK(h) --> Tie2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
140 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 158 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 399 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 438 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 464 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 560 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 596 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 649 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 691 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 992 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 1102 | Phosphotyrosine (Tie2) | 10521483;9632797;12082108 | Phospho.ELM 6.0 | 1113 | Phosphotyrosine (Tie2) | 10521483;12665569 | Phospho.ELM 6.0 | 1108 | Phosphotyrosine (Tie2) | 10521483;12665569 | Phospho.ELM 6.0 | 897 | Phosphotyrosine | 11080633;11513602 | Phospho.ELM 6.0 | 1048 | Phosphotyrosine (Tie2) | 11080633;11513602 | Phospho.ELM 6.0 | 992 | Phosphotyrosine (Tie2) | 11513602;93173509 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr9 |
Promoter: 27097786 - 27099786 | GoldenGate_Methylation_Cancer_Panel_I |
chr9 |
Promoter: 27097786 - 27099786 | GSE27584 |