| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7045 |
Name | TGFBI |
Synonym | BIGH3|CDB1|CDG2|CDGG1|CSD|CSD1|CSD2|CSD3|EBMD|LCD1;transforming growth factor, beta-induced, 68kDa;TGFBI;transforming growth factor, beta-induced, 68kDa |
Definition | RGD-CAP|RGD-containing collagen-associated protein|beta ig-h3|kerato-epithelin|transforming growth factor-beta-induced protein ig-h3 |
Position | 5q31 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "In the present study, we determined that pulmonary arteries in normal lungs and in lungs of patients with emphysema and idiopathic pulmonary arterial hypertension comparably expressed transforming growth factor-beta receptors I and II, Smad(1, 5, 8), Smad2, Smad3, Smad4, phosphorylated Smad(1, 5, 8), and phosphorylated Smad2 (the latter two both indicative of active in vivo signaling) in endothelial cells, as assessed by immunohistochemistry and quantitative morphometry. Medial or intimal smooth muscle cells had weak or absent expression of these molecules. In clear contrast to endothelial cell expression in pulmonary arteries and in endothelial cells lining incipient vessels within plexiform lesions of hypertensive lungs, endothelial cells present in the core of the lesions lacked expression of all examined members of the signaling molecules. ". |
| More detail of all Human literatures about TGFBI | |
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External Links |
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Links to Entrez Gene | 7045 |
Links to all GeneRIF Items | 7045 |
Links to iHOP | 7045 |
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Sequence Information |
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Nucleotide Sequence |
>7045 : length: 2052 atggcgctcttcgtgcggctgctggctctcgccctggctctggccctgggccccgccgcg accctggcgggtcccgccaagtcgccctaccagctggtgctgcagcacagcaggctccgg ggccgccagcacggccccaacgtgtgtgctgtgcagaaggttattggcactaataggaag tacttcaccaactgcaagcagtggtaccaaaggaaaatctgtggcaaatcaacagtcatc agctacgagtgctgtcctggatatgaaaaggtccctggggagaagggctgtccagcagcc ctaccactctcaaacctttacgagaccctgggagtcgttggatccaccaccactcagctg tacacggaccgcacggagaagctgaggcctgagatggaggggcccggcagcttcaccatc ttcgcccctagcaacgaggcctgggcctccttgccagctgaagtgctggactccctggtc agcaatgtcaacattgagctgctcaatgccctccgctaccatatggtgggcaggcgagtc ctgactgatgagctgaaacacggcatgaccctcacctctatgtaccagaattccaacatc cagatccaccactatcctaatgggattgtaactgtgaactgtgcccggctgctgaaagcc gaccaccatgcaaccaacggggtggtgcacctcatcgataaggtcatctccaccatcacc aacaacatccagcagatcattgagatcgaggacacctttgagacccttcgggctgctgtg gctgcatcagggctcaacacgatgcttgaaggtaacggccagtacacgcttttggccccg accaatgaggccttcgagaagatccctagtgagactttgaaccgtatcctgggcgaccca gaagccctgagagacctgctgaacaaccacatcttgaagtcagctatgtgtgctgaagcc atcgttgcggggctgtctgtagagaccctggagggcacgacactggaggtgggctgcagc ggggacatgctcactatcaacgggaaggcgatcatctccaataaagacatcctagccacc aacggggtgatccactacattgatgagctactcatcccagactcagccaagacactattt gaattggctgcagagtctgatgtgtccacagccattgaccttttcagacaagccggcctc ggcaatcatctctctggaagtgagcggttgaccctcctggctcccctgaattctgtattc aaagatggaacccctccaattgatgcccatacaaggaatttgcttcggaaccacataatt aaagaccagctggcctctaagtatctgtaccatggacagaccctggaaactctgggcggc aaaaaactgagagtttttgtttatcgtaatagcctctgcattgagaacagctgcatcgcg gcccacgacaagagggggaggtacgggaccctgttcacgatggaccgggtgctgaccccc ccaatggggactgtcatggatgtcctgaagggagacaatcgctttagcatgctggtagct gccatccagtctgcaggactgacggagaccctcaaccgggaaggagtctacacagtcttt gctcccacaaatgaagccttccgagccctgccaccaagagaacggagcagactcttggga gatgccaaggaacttgccaacatcctgaaataccacattggtgatgaaatcctggttagc ggaggcatcggggccctggtgcggctaaagtctctccaaggtgacaagctggaagtcagc ttgaaaaacaatgtggtgagtgtcaacaaggagcctgttgccgagcctgacatcatggcc acaaatggcgtggtccatgtcatcaccaatgttctgcagcctccagccaacagacctcag gaaagaggggatgaacttgcagactctgcgcttgagatcttcaaacaagcatcagcgttt tccagggcttcccagaggtctgtgcgactagcccctgtctatcaaaagttattagagagg atgaagcattag |
Protein Sequence |
>7045 : length: 683 MALFVRLLALALALALGPAATLAGPAKSPYQLVLQHSRLRGRQHGPNVCAVQKVIGTNRK YFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQL YTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRV LTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTIT NNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDP EALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILAT NGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVF KDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIA AHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVF APTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVS LKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPANRPQERGDELADSALEIFKQASAF SRASQRSVRLAPVYQKLLERMKH |