Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7157

Name

TP53

Synonym

BCC7|LFS1|P53|TRP53;tumor protein p53;TP53;tumor protein p53

Definition

antigen NY-CO-13|cellular tumor antigen p53|p53 tumor suppressor|phosphoprotein p53|transformation-related protein 53

Position

17p13.1

Gene Type

protein-coding

PAH Type

Description

HPH

p53 Gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice.
More detail of all Mouse literatures about TP53

Pathways and Diseases

Pathway

estrogen responsive protein efp controls cell cycle and breast tumors growth;PID BioCarta;100182

Pathway

Glucocorticoid receptor regulatory network;PID Curated;200077

Pathway

Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722

Pathway

BARD1 signaling events;PID Curated;200174

Pathway

PLK3 signaling events;PID Curated;200186

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

Endometrial cancer;KEGG PATHWAY;hsa05213

Pathway

regulation of transcriptional activity by pml;PID BioCarta;100067

Pathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha;PID Curated;200122

Pathway

Basal cell carcinoma;KEGG PATHWAY;hsa05217

Pathway

cell cycle: g1/s check point;PID BioCarta;100160

Pathway

Huntington's disease;KEGG PATHWAY;hsa05016

Pathway

btg family proteins and cell cycle regulation;PID BioCarta;100224

Pathway

p75(NTR)-mediated signaling;PID Curated;200103

Pathway

Pancreatic cancer;KEGG PATHWAY;hsa05212

Pathway

Wnt signaling pathway;KEGG PATHWAY;hsa04310

Pathway

apoptotic signaling in response to dna damage;PID BioCarta;100204

Pathway

cell cycle: g2/m checkpoint;PID BioCarta;100159

Pathway

Transcriptional activation of cell cycle inhibitor p21;PID Reactome;501023

Pathway

Apoptosis;KEGG PATHWAY;hsa04210

Pathway

Chronic myeloid leukemia;KEGG PATHWAY;hsa05220

Pathway

Small cell lung cancer;KEGG PATHWAY;hsa05222

Pathway

P53 pathway feedback loops 1;PANTHER;P04392

Pathway

Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014

Pathway

tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237

Pathway

Bladder cancer;KEGG PATHWAY;hsa05219

Pathway

Signaling mediated by p38-alpha and p38-beta;PID Curated;200154

Pathway

Hepatitis C;KEGG PATHWAY;hsa05160

Pathway

atm signaling pathway;PID BioCarta;100235

Pathway

Validated targets of C-MYC transcriptional activation;PID Curated;200045

Pathway

rb tumor suppressor/checkpoint signaling in response to dna damage;PID BioCarta;100046

Pathway

Colorectal cancer;KEGG PATHWAY;hsa05210

Pathway

LKB1 signaling events;PID Curated;200061

Pathway

p53 pathway;PANTHER;P00059

Pathway

Autodegradation of the E3 ubiquitin ligase COP1;PID Reactome;500317

Pathway

Signaling events mediated by HDAC Class III;PID Curated;200020

Pathway

hypoxia and p53 in the cardiovascular system;PID BioCarta;100084

Pathway

p53 signaling pathway;PID BioCarta;100083

Pathway

Wnt signaling pathway;PANTHER;P00057

Pathway

double stranded rna induced gene expression;PID BioCarta;100040

Pathway

p53 pathway by glucose deprivation;PANTHER;P04397

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

AP-1 transcription factor network;PID Curated;200118

Pathway

regulation of cell cycle progression by plk3;PID BioCarta;100068

Pathway

Non-small cell lung cancer;KEGG PATHWAY;hsa05223

Pathway

Aurora A signaling;PID Curated;200166

Pathway

Cell cycle;KEGG PATHWAY;hsa04110

Pathway

Huntington disease;PANTHER;P00029

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Thyroid cancer;KEGG PATHWAY;hsa05216

Pathway

p53 pathway;PID Curated;200175

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

role of brca1 brca2 and atr in cancer susceptibility;PID BioCarta;100234

Pathway

Stabilization of p53;PID Reactome;500316

Pathway

telomeres telomerase cellular aging and immortality;PID BioCarta;100021

Pathway

Cell Cycle Checkpoints;Reactome;REACT:1538

Pathway

Apoptosis signaling pathway;PANTHER;P00006

Pathway

overview of telomerase protein component gene htert transcriptional regulation;PID BioCarta;100019

Pathway

p53 pathway feedback loops 2;PANTHER;P04398

Pathway

p53 signaling pathway;KEGG PATHWAY;hsa04115

Pathway

chaperones modulate interferon signaling pathway;PID BioCarta;100016

Pathway

Direct p53 effectors;PID Curated;200101

Disease

Colorectal cancer;KEGG DISEASE;H00020

Disease

Thyroid cancer;KEGG DISEASE;H00032

Disease

tumour progression;GAD

Disease

Adrenal carcinoma;KEGG DISEASE;H00033

Disease

Colorectal cancer;OMIM

Disease

squamous cell carcinoma;GAD

Disease

tumor progression of BCR/ABL negative chronic myeloproliferative disorders;GAD

Disease

Bladder cancer;KEGG DISEASE;H00022

Disease

Leukemia, Myeloid, Acute;GAD

Disease

Xeroderma pigmentosum;GAD

Disease

Skin cancers;KEGG DISEASE

Disease

aggressive behavior of chondrosarcoma;GAD

Disease

albuminuria among aboriginal Australians;GAD

Disease

brain tumors;GAD

Disease

Osteosarcoma;KEGG DISEASE;H00036

Disease

IMMUNE;GAD

Disease

Breast cancer;OMIM

Disease

Viral infections;KEGG DISEASE

Disease

ring sideroblasts;GAD

Disease

Hairy-cell leukemia;KEGG DISEASE;H00006

Disease

PSYCH;GAD

Disease

Non-small cell lung cancer;KEGG DISEASE;H00014

Disease

metastases;GAD

Disease

colorectal adenocarcinomas;GAD

Disease

Penile cancer;KEGG DISEASE;H00025

Disease

Li-Fraumeni syndrome;OMIM

Disease

decreased chemosensitivity;GAD

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Small cell lung cancer;KEGG DISEASE;H00013

Disease

Head and neck squamous cell cancer;GAD

Disease

Malignant melanoma;KEGG DISEASE;H00038

Disease

Burkitt lymphoma;KEGG DISEASE;H00008

Disease

smoking;GAD

Disease

Neoplasms;GAD

Disease

cerebral infarct, atherothrombotic;GAD

Disease

skin carcinomas;GAD

Disease

increased aggressiveness;GAD

Disease

Pancreatic cancer;KEGG DISEASE;H00019

Disease

tumor proliferation and other prognostic indicators;GAD

Disease

cervical cancer ovarian cancer;GAD

Disease

Infections caused by retro-transcribing viruses;KEGG DISEASE

Disease

hepatitis C virus infection;GAD

Disease

Multiple myeloma;KEGG DISEASE;H00010

Disease

Vulvar cancer;KEGG DISEASE;H00029

Disease

Cancer of the anal canal;KEGG DISEASE;H00044

Disease

breast cancer by the age of 50 years;GAD

Disease

prostate cancer;GAD

Disease

Li-Fraumeni-like syndrome;OMIM

Disease

Glioblastoma;GAD

Disease

Breast cancer;KEGG DISEASE;H00031

Disease

Lung Neoplasms;GAD

Disease

Adrenal cortical carcinoma;OMIM

Disease

Endometrial cancer;KEGG DISEASE;H00026

Disease

increased lung cancer risk;GAD

Disease

Adult T-cell leukemia;KEGG DISEASE;H00009

Disease

Lymphoma, Large B-Cell, Diffuse;GAD

Disease

Cancers of the urinary system and male genital organs;KEGG DISEASE

Disease

liver cancer;GAD

Disease

CANCER;GAD

Disease

Esophageal cancer;KEGG DISEASE;H00017

Disease

chronic obstructive pulmonary disease/COPD;GAD

Disease

Kaposi's sarcoma;KEGG DISEASE;H00041

Disease

endometrial cancer;GAD

Disease

Osteosarcoma;OMIM

Disease

ulcerative colitis;GAD

Disease

ovarian carcinoma;GAD

Disease

Pancreatic cancer;OMIM

Disease

sensitivity to TZT-1027;GAD

Disease

Basal cell carcinoma;KEGG DISEASE;H00039

Disease

mucosa-associated lymphoid tissue lymphoma;GAD

Disease

metastatic progression and poor survival;GAD

Disease

Choroid plexus papilloma;OMIM

Disease

progression of a prostate carcinoma;GAD

Disease

PHARMACOGENOMIC;GAD

Disease

Choriocarcinoma;KEGG DISEASE;H00028

Disease

METABOLIC;GAD

Disease

Cancers of the digestive system;KEGG DISEASE

Disease

Malignant pleural mesothelioma;KEGG DISEASE;H00015

Disease

colorectal cancer;GAD

Disease

soft tissue sarcoma;GAD

Disease

gastric cancer;GAD

Disease

Hepatocellular carcinoma;KEGG DISEASE;H00048

Disease

Ovarian cancer;KEGG DISEASE;H00027

Disease

Leukemia, Lymphocytic, Chronic, B-Cell;GAD

Disease

pancreatic adenocarcinoma;GAD

Disease

Laryngeal cancer;KEGG DISEASE;H00055

Disease

Squamous cell carcinoma;KEGG DISEASE;H00040

Disease

INFECTION;GAD

Disease

betel-quid chewing;GAD

Disease

Cancers;KEGG DISEASE

Disease

non-small cell lung carcinoma;GAD

Disease

breast cancer;GAD

Disease

ovarian cancer;GAD

Disease

stomach cancer;GAD

Disease

Cholangiocarcinoma;KEGG DISEASE;H00046

Disease

Gastric cancer;KEGG DISEASE;H00018

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

Cancers of soft tissues and bone;KEGG DISEASE

Disease

breast carcinoma;GAD

Disease

Nasopharyngeal carcinoma;OMIM

Disease

Chronic myeloid leukemia (CML);KEGG DISEASE;H00004

Disease

colorectal cancers;GAD

Disease

bladder cancer;GAD

Disease

Hepatocellular carcinoma;OMIM

Disease

non-small cell lung cancer;GAD

Disease

lung cancer;GAD

Disease

cervical cancer;GAD

Disease

Cancers of haematopoietic and lymphoid tissues;KEGG DISEASE

Disease

Cancers of endocrine organs;KEGG DISEASE

Disease

DNA Damage;GAD

Disease

oesophageal squamous cell carcinoma;GAD

Disease

psoriatic arthritis;GAD

Disease

malignant myeloid disorders;GAD

Disease

esophageal cancer;GAD

Disease

breast cancer survival;GAD

Disease

malignant cystosarcoma phyllodes and soft tissue sarcoma;GAD

Disease

CARDIOVASCULAR;GAD

Disease

Chronic lymphocytic leukemia (CLL);KEGG DISEASE;H00005

Disease

Oral cancer;KEGG DISEASE;H00016

Disease

Infections caused by dsDNA viruses;KEGG DISEASE

Disease

Cancers of the breast and female genital organs;KEGG DISEASE

Disease

keloid;GAD

Disease

Gallbladder cancer;KEGG DISEASE;H00047

Disease

gastritis, chronic atrophic;GAD

Disease

Glioma;KEGG DISEASE;H00042

Disease

alpha-particle carcinogenesis;GAD

Disease

Head and neck cancers;KEGG DISEASE

Disease

Brain Neoplasms;GAD

External Links

Links to Entrez Gene

7157

Links to all GeneRIF Items

7157

Links to iHOP

7157

Sequence Information

Nucleotide Sequence

>7157 : length: 1182
atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttca
gacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatg
gatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtcca
gatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcct
acaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccag
aaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaag
tctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacc
tgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatg
gccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgag
cgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaat
ttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctat
gagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagt
tcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactcc
agtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggaga
gaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgccc
ccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaag
aaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatg
ttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggg
gggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccat
aaaaaactcatgttcaagacagaagggcctgactcagactga

Protein Sequence

>7157 : length: 393
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD



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