| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 718 |
Name | C3 |
Synonym | AHUS5|ARMD9|ASP|C3a|C3b|CPAMD1;complement component 3;C3;complement component 3 |
Definition | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|prepro-C3 |
Position | 19p13.3-p13.2 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PH | The complement system plays a pathophysiologic role in the development of pulmonary hypertension in mice. |
| More detail of all Mouse literatures about C3 | |
|
Pathways and Diseases |
|
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | alternative complement pathway;PID BioCarta;100243 |
Pathway | classical complement pathway;PID BioCarta;100200 |
Pathway | Peptide ligand-binding receptors;PID Reactome;500405 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | lectin induced complement pathway;PID BioCarta;100118 |
Pathway | Staphylococcus aureus infection;KEGG PATHWAY;hsa05150 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Systemic lupus erythematosus;KEGG PATHWAY;hsa05322 |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Activation of C3 and C5;PID Reactome;500476 |
Pathway | Alternative complement activation;PID Reactome;500474 |
Pathway | Phagosome;KEGG PATHWAY;hsa04145 |
Disease | Lupus erythematosus;FunDO |
Disease | Hemolytic uremic syndrome, atypical, susceptibility to, 5;OMIM |
Disease | Macular degeneration;FunDO |
Disease | Kidney disease;FunDO |
Disease | Depression;FunDO |
Disease | cirrhosis;GAD |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | IMMUNE;GAD |
Disease | Asthma;GAD |
Disease | Dental plaque;FunDO |
Disease | Stroke;FunDO |
Disease | INFECTION;GAD |
Disease | Alzheimer's disease;FunDO |
Disease | Drug abuse;FunDO |
Disease | Tuberculosis;FunDO |
Disease | Endometriosis;FunDO |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Aortic valve disease;FunDO |
Disease | respiratory syncytial virus bronchiolitis;GAD |
Disease | Age-related macular degeneration;NHGRI |
Disease | Hyperlipidemia;FunDO |
Disease | Classic complement pathway component defects;KEGG DISEASE;H00102 |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Macular degeneration, age-related, 9;OMIM |
Disease | Infertility;FunDO |
Disease | C3 deficiency;OMIM |
|
External Links |
|
Links to Entrez Gene | 718 |
Links to all GeneRIF Items | 718 |
Links to iHOP | 718 |
|
Sequence Information |
|
Nucleotide Sequence |
>718 : length: 4992 atgggacccacctcaggtcccagcctgctgctcctgctactaacccacctccccctggct ctggggagtcccatgtactctatcatcacccccaacatcttgcggctggagagcgaggag accatggtgctggaggcccacgacgcgcaaggggatgttccagtcactgttactgtccac gacttcccaggcaaaaaactagtgctgtccagtgagaagactgtgctgacccctgccacc aaccacatgggcaacgtcaccttcacgatcccagccaacagggagttcaagtcagaaaag gggcgcaacaagttcgtgaccgtgcaggccaccttcgggacccaagtggtggagaaggtg gtgctggtcagcctgcagagcgggtacctcttcatccagacagacaagaccatctacacc cctggctccacagttctctatcggatcttcaccgtcaaccacaagctgctacccgtgggc cggacggtcatggtcaacattgagaacccggaaggcatcccggtcaagcaggactccttg tcttctcagaaccagcttggcgtcttgcccttgtcttgggacattccggaactcgtcaac atgggccagtggaagatccgagcctactatgaaaactcaccacagcaggtcttctccact gagtttgaggtgaaggagtacgtgctgcccagtttcgaggtcatagtggagcctacagag aaattctactacatctataacgagaagggcctggaggtcaccatcaccgccaggttcctc tacgggaagaaagtggagggaactgcctttgtcatcttcgggatccaggatggcgaacag aggatttccctgcctgaatccctcaagcgcattccgattgaggatggctcgggggaggtt gtgctgagccggaaggtactgctggacggggtgcagaacccccgagcagaagacctggtg gggaagtctttgtacgtgtctgccaccgtcatcttgcactcaggcagtgacatggtgcag gcagagcgcagcgggatccccatcgtgacctctccctaccagatccacttcaccaagaca cccaagtacttcaaaccaggaatgccctttgacctcatggtgttcgtgacgaaccctgat ggctctccagcctaccgagtccccgtggcagtccagggcgaggacactgtgcagtctcta acccagggagatggcgtggccaaactcagcatcaacacacaccccagccagaagcccttg agcatcacggtgcgcacgaagaagcaggagctctcggaggcagagcaggctaccaggacc atgcaggctctgccctacagcaccgtgggcaactccaacaattacctgcatctctcagtg ctacgtacagagctcagacccggggagaccctcaacgtcaacttcctcctgcgaatggac cgcgcccacgaggccaagatccgctactacacctacctgatcatgaacaagggcaggctg ttgaaggcgggacgccaggtgcgagagcccggccaggacctggtggtgctgcccctgtcc atcaccaccgacttcatcccttccttccgcctggtggcgtactacacgctgatcggtgcc agcggccagagggaggtggtggccgactccgtgtgggtggacgtcaaggactcctgcgtg ggctcgctggtggtaaaaagcggccagtcagaagaccggcagcctgtacctgggcagcag atgaccctgaagatagagggtgaccacggggcccgggtggtactggtggccgtggacaag ggcgtgttcgtgctgaataagaagaacaaactgacgcagagtaagatctgggacgtggtg gagaaggcagacatcggctgcaccccgggcagtgggaaggattacgccggtgtcttctcc gacgcagggctgaccttcacgagcagcagtggccagcagaccgcccagagggcagaactt cagtgcccgcagccagccgcccgccgacgccgttccgtgcagctcacggagaagcgaatg gacaaagtcggcaagtaccccaaggagctgcgcaagtgctgcgaggacggcatgcgggag aaccccatgaggttctcgtgccagcgccggacccgtttcatctccctgggcgaggcgtgc aagaaggtcttcctggactgctgcaactacatcacagagctgcggcggcagcacgcgcgg gccagccacctgggcctggccaggagtaacctggatgaggacatcattgcagaagagaac atcgtttcccgaagtgagttcccagagagctggctgtggaacgttgaggacttgaaagag ccaccgaaaaatggaatctctacgaagctcatgaatatatttttgaaagactccatcacc acgtgggagattctggctgtgagcatgtcggacaagaaagggatctgtgtggcagacccc ttcgaggtcacagtaatgcaggacttcttcatcgacctgcggctaccctactctgttgtt cgaaacgagcaggtggaaatccgagccgttctctacaattaccggcagaaccaagagctc aaggtgagggtggaactactccacaatccagccttctgcagcctggccaccaccaagagg cgtcaccagcagaccgtaaccatcccccccaagtcctcgttgtccgttccatatgtcatc gtgccgctaaagaccggcctgcaggaagtggaagtcaaggctgctgtctaccatcatttc atcagtgacggtgtcaggaagtccctgaaggtcgtgccggaaggaatcagaatgaacaaa actgtggctgttcgcaccctggatccagaacgcctgggccgtgaaggagtgcagaaagag gacatcccacctgcagacctcagtgaccaagtcccggacaccgagtctgagaccagaatt ctcctgcaagggaccccagtggcccagatgacagaggatgccgtcgacgcggaacggctg aagcacctcattgtgaccccctcgggctgcggggaacagaacatgatcggcatgacgccc acggtcatcgctgtgcattacctggatgaaacggagcagtgggagaagttcggcctagag aagcggcagggggccttggagctcatcaagaaggggtacacccagcagctggccttcaga caacccagctctgcctttgcggccttcgtgaaacgggcacccagcacctggctgaccgcc tacgtggtcaaggtcttctctctggctgtcaacctcatcgccatcgactcccaagtcctc tgcggggctgttaaatggctgatcctggagaagcagaagcccgacggggtcttccaggag gatgcgcccgtgatacaccaagaaatgattggtggattacggaacaacaacgagaaagac atggccctcacggcctttgttctcatctcgctgcaggaggctaaagatatttgcgaggag caggtcaacagcctgccaggcagcatcactaaagcaggagacttccttgaagccaactac atgaacctacagagatcctacactgtggccattgctggctatgctctggcccagatgggc aggctgaaggggcctcttcttaacaaatttctgaccacagccaaagataagaaccgctgg gaggaccctggtaagcagctctacaacgtggaggccacatcctatgccctcttggcccta ctgcagctaaaagactttgactttgtgcctcccgtcgtgcgttggctcaatgaacagaga tactacggtggtggctatggctctacccaggccaccttcatggtgttccaagccttggct caataccaaaaggacgcccctgaccaccaggaactgaaccttgatgtgtccctccaactg cccagccgcagctccaagatcacccaccgtatccactgggaatctgccagcctcctgcga tcagaagagaccaaggaaaatgagggtttcacagtcacagctgaaggaaaaggccaaggc accttgtcggtggtgacaatgtaccatgctaaggccaaagatcaactcacctgtaataaa ttcgacctcaaggtcaccataaaaccagcaccggaaacagaaaagaggcctcaggatgcc aagaacactatgatccttgagatctgtaccaggtaccggggagaccaggatgccactatg tctatattggacatatccatgatgactggctttgctccagacacagatgacctgaagcag ctggccaatggtgttgacagatacatctccaagtatgagctggacaaagccttctccgat aggaacaccctcatcatctacctggacaaggtctcacactctgaggatgactgtctagct ttcaaagttcaccaatactttaatgtagagcttatccagcctggagcagtcaaggtctac gcctattacaacctggaggaaagctgtacccggttctaccatccggaaaaggaggatgga aagctgaacaagctctgccgtgatgaactgtgccgctgtgctgaggagaattgcttcata caaaagtcggatgacaaggtcaccctggaagaacggctggacaaggcctgtgagccagga gtggactatgtgtacaagacccgactggtcaaggttcagctgtccaatgactttgacgag tacatcatggccattgagcagaccatcaagtcaggctcggatgaggtgcaggttggacag cagcgcacgttcatcagccccatcaagtgcagagaagccctgaagctggaggagaagaaa cactacctcatgtggggtctctcctccgatttctggggagagaagcccaacctcagctac atcatcgggaaggacacttgggtggagcactggcccgaggaggacgaatgccaagacgaa gagaaccagaaacaatgccaggacctcggcgccttcaccgagagcatggttgtctttggg tgccccaactga |
Protein Sequence |
>718 : length: 1663 MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN |