| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 718 |
Name | C3 |
Synonymous | AHUS5|ARMD9|ASP|C3a|C3b|CPAMD1;complement component 3;C3;complement component 3 |
Definition | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1|C3a anaphylatoxin|acylation-stimulating protein cleavage product|complement C3|complement component C3|complement component C3a|complement component C3b|prepro-C3 |
Position | 19p13.3-p13.2 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
|
Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr19:6677715-6730573 | chr19:6722022-6722022 | rs339392 | Single_Nucleotides|eQTL|C3, Single_Nucleotides|eQTL|C3, Chromatin_Structure|DNase-seq|Cll, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|FAIRE|Gm12891, Chromatin_Structure|FAIRE|Gm19239, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Gm19240, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|FAIRE|Gm18507, Chromatin_Structure|DNase-seq|Gm18507, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Gm06990, Protein_Binding|ChIP-seq|SPI1, Protein_Binding|ChIP-seq|SPI1 | chr19:6677715-6730573 | chr19:6722635-6722635 | rs163913 | Single_Nucleotides|eQTL|C3, Single_Nucleotides|eQTL|C3, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|PWM|GATA-1, Chromatin_Structure|FAIRE|Gm18507, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|Gm19240, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|FAIRE|Gm12878, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|FAIRE|Gm19239 |
|---|---|---|---|
Transcription Factors [Top] |
|
Regulation From TransFac database |
CD11B(h):beta2-integrin(h) + complement C3(h) <==> CD11B(h):beta2-integrin(h):complement C3(h) (binding) | CD11B(m.s.):beta2-integrin(m.s.) + complement C3(h) <==> CD11B(m.s.):beta2-integrin(m.s.):complement C3(h) (binding) | complement C3(h) + CD11B(m.s.) <==> complement C3(h):CD11B(m.s.) (binding) | complement C3(h) + beta2-integrin(m.s.) <==> complement C3(h):beta2-integrin(m.s.) (binding) | CD11B(m):beta2-integrin(m) + complement C3(h) <==> CD11B(m):beta2-integrin(m):complement C3(h) (binding) | complement C3(h) + CD35(h) <==> complement C3(h):CD35(h) (binding) | complement C3(h) + CD35(h) <==> complement C3(h):CD35(h) (binding) | complement C3(h) + DAF(h) <==> complement C3(h):DAF(h) (binding) | complement C3(h) + factor H(h) <==> complement C3(h):factor H(h) (binding) | complement C3(h) --> iC3b(h) + protein remnants (cleavage) | complement C3(h) + ATP --LPK1(LEIMAFR)--> complement C3(h){p} + ADP (phosphorylation) | complement C3(h) --trypsin-1(m.s.)--> C3a(h) + C3b(h) + protein remnants (cleavage) | Keratin-1(h) + complement C3(h) <==> Keratin-1(h):complement C3(h) (binding) | C3(h) --> complement C3(h) (expression). | CD11B(h) + complement C3(h) <==> CD11B(h):complement C3(h) (binding) | CD11B(m.s.):beta2-integrin(m.s.) + complement C3(h) <==> CD11B(m.s.):beta2-integrin(m.s.):complement C3(h) (binding) | complement C3(h) + CD11B(m.s.) <==> complement C3(h):CD11B(m.s.) (binding) | complement C3(h) + beta2-integrin(m.s.) <==> complement C3(h):beta2-integrin(m.s.) (binding) | complement C3(h) --IF(h)--> complement C3 beta chain(h) + complement C3 alpha 40(h) + complement C3 alpha 75(h) + protein remnants (cleavage) | complement C3(h) --IF(h)--> complement C3 beta chain(h) + complement C3 alpha 40(h) + complement C3 alpha p37(h) + protein remnants (cleavage) | complement C3(h) --IF(b)--> complement C3 alpha 75(h) + complement C3 beta chain(h) + complement C3 alpha 40(h) + protein remnants (cleavage) | C3(h) --> complement C3(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
85 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 939 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 1617 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 1010 | Isoglutamyl cysteine thioester (Cys-Gln). | Swiss-Prot 53.0 | 742 | Phosphoserine | 1756717 | Phospho.ELM 6.0 | 1031 | Phosphothreonine | 10358196 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
There is no record for C3 | ||