| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 7225 |
Name | TRPC6 |
Synonym | FSGS2|TRP6;transient receptor potential cation channel, subfamily C, member 6;TRPC6;transient receptor potential cation channel, subfamily C, member 6 |
Definition | TRP-6|short transient receptor potential channel 6|transient receptor protein 6 |
Position | 11q22.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle. |
PAH | Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. |
PAH | A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. |
PAH | Recent reports of elevated transient receptor potential (TRP) calcium channels TRP3 and TRP6 in PA SMCs from IPAH patients indicated that inhibition of these channels can repress the heightened proliferation observed in SMCs. Inhibition of PKA or activation of cAMP seem to have a similar effect. |
PH | Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. |
| More detail of all Rat literatures about TRPC6 | |
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Pathways and Diseases |
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Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | ion channels and their functional role in vascular endothelium;PID BioCarta;100055 |
Disease | Hyperglycemia;FunDO |
Disease | Embryoma;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
Disease | Glomerulosclerosis, focal segmental, 2;OMIM |
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External Links |
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Links to Entrez Gene | 7225 |
Links to all GeneRIF Items | 7225 |
Links to iHOP | 7225 |
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Sequence Information |
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Nucleotide Sequence |
>7225 : length: 2796 atgagccagagcccggcgttcgggccccggaggggcagttctccccggggcgctgccgga gccgctgcgcggcgcaacgagagccaggactatctgctcatggactcggagctgggagaa gacggctgcccgcaagccccgctgccttgctacggctactacccctgcttccggggatct gacaacagactggctcaccggcggcagacagttctccgtgagaaggggagaaggttagct aatcgaggaccagcatacatgtttagtgatcgctccacaagcctatctatagaggaggaa cgctttttggatgcagctgaatatggtaacatcccagtggtgcggaagatgttagaagaa tgccactcactcaacgttaactgtgtggattacatgggccagaatgccctacagttggca gtggccaatgagcatctggaaattacagaacttcttctcaagaaagaaaacctctctcga gttggggatgctttgcttctagctattagtaaaggttatgttcggattgtggaagcaatt ctcagtcatccggcttttgctgaaggcaagaggttagcaaccagccctagccagtctgaa ctccagcaagatgatttttatgcctatgatgaagatgggacacggttctcccatgatgtg actccaatcattctggctgcccactgccaggaatatgaaattgtgcataccctcctgcgg aagggtgctaggattgaacggcctcatgattatttctgcaagtgcaatgactgcaaccag aaacagaagcatgactcgtttagccactccagatctaggattaatgcctataaaggcctg gcaagtccggcttacctgtcattgtctagtgaagatccagtcatgacggctttagaactt agcaatgaactggcagttctggccaatattgagaaagagttcaagaatgactacaaaaaa ctgtcaatgcagtgcaaagactttgttgttggactccttgatctgtgcagaaacactgaa gaagtcgaggccattctgaatggggatgttgaaacgctccagagtggtgatcacggtcgc ccaaatctcagccgtttaaaacttgccattaaatatgaagtaaaaaaatttgtagctcat ccaaactgccaacagcaacttctctccatttggtatgagaatctttctggtttacgacag cagacaatggcggtcaagttccttgtggtccttgctgttgccattggactgcccttcctg gctctcatttactggtttgctccatgcagcaagatggggaagataatgcgtggaccattc atgaagtttgtagcacacgcagcctccttcaccatttttctgggactgctagtcatgaat gcagctgacagatttgaaggcacaaaactccttcctaatgaaaccagcacagataatgca aaacagctgttcaggatgaaaacatcctgcttctcatggatggagatgctcattatatcc tgggtaataggcatgatatgggctgaatgtaaagaaatctggactcagggccccaaggaa tatttgtttgagttgtggaacatgcttgattttggtatgttagcaattttcgcagcatca ttcattgcgagattcatggcattttggcatgcttccaaagcccagagcatcattgacgca aatgatactttgaaggacttgacgaaagtaacattgggagacaatgtgaaatactacaat ttggccaggataaagtgggacccctctgatcctcaaataatatctgaaggtctttatgca attgctgtagttttaagtttctctaggatagcttatattttaccagcaaatgaaagcttt ggacctctgcagatatcacttggaagaacagtcaaagacatcttcaagttcatggtcata ttcattatggtgtttgtggcctttatgattggaatgttcaatctctactcctactacatt ggtgcaaaacaaaatgaagccttcacaacagttgaagagagttttaagacactgttctgg gctatatttggactttctgaagtgaaatcagtggtcatcaactataaccacaaattcatt gaaaacattggttacgttctttatggagtctataatgttacgatggtcattgttttgcta aatatgttaattgccatgatcaacagttcattccaggaaattgaggatgacgctgatgtg gagtggaaatttgcaagggccaaactctggttttcctactttgaggagggcagaacactt cctgtacccttcaatctggtgccgagtccaaagtccctgttttatctcttactgaagctt aaaaaatggatttctgagctgttccagggccataaaaaaggtttccaggaagatgcagag atgaacaagataaatgaagaaaagaaacttggaattttaggaagtcatgaagacctttca aaattatcacttgacaaaaaacaggttgggcacaataaacaaccaagtataaggagctca gaagatttccatctaaatagtttcaataatcctccaagacaatatcagaaaataatgaaa aggctcattaaaagatatgtactgcaggcccagatagataaggagagtgatgaagtgaac gaaggggaactgaaggaaattaagcaggacatctcaagtctccgctatgaactccttgaa gaaaaatctcagaatacagaagacctagcagaacttattagagaacttggagagaaatta tccatggaaccaaatcaagaggaaaccaatagataa |
Protein Sequence |
>7225 : length: 931 MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGS DNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEE CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAI LSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLR KGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALEL SNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGR PNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFL ALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNA KQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAAS FIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYA IAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYI GAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLL NMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKL KKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSS EDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLE EKSQNTEDLAELIRELGEKLSMEPNQEETNR |