| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 7450 |
Name | VWF |
Synonym | F8VWF|VWD;von Willebrand factor;VWF;von Willebrand factor |
Definition | coagulation factor VIII VWF |
Position | 12p13.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | The increase of the level of endothelin-1 and the activity of von Willebrand factor is a risk factor of the development of pulmonary hypertension in children with chronic bronchopulmonary pathology. |
| More detail of all Human literatures about VWF | |
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Pathways and Diseases |
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Pathway | vWF interaction with collagen;PID Reactome;500977 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Intrinsic Pathway;PID Reactome;500302 |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | von Willebrand disease, autosomal recessive;OMIM |
Disease | dominant type 1 von Willebrand's disease;GAD |
Disease | Breast cancer;FunDO |
Disease | nephropathy;GAD |
Disease | Neoplasm metastasis;FunDO |
Disease | Hypercholesterolemia;FunDO |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | coronary heart disease;GAD |
Disease | Systemic infection;FunDO |
Disease | METABOLIC;GAD |
Disease | Yersinia infection;FunDO |
Disease | Bacterial infection;FunDO |
Disease | plasma vWF;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | Glycogen storage disease;FunDO |
Disease | von Willebrand disease, autosomal dominant;OMIM |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | Uterine fibroids;FunDO |
Disease | Hemophilia;KEGG DISEASE;H00219 |
Disease | Hemorrhagic disorder;FunDO |
Disease | Hypertension;FunDO |
Disease | Behcet syndrome;FunDO |
Disease | Congenital abnormality;FunDO |
Disease | type 1 von Willebrand disease;GAD |
Disease | Atherosclerosis;FunDO |
Disease | blood pressure, arterial hypertension;GAD |
Disease | RENAL;GAD |
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External Links |
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Links to Entrez Gene | 7450 |
Links to all GeneRIF Items | 7450 |
Links to iHOP | 7450 |
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Sequence Information |
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Nucleotide Sequence |
>7450 : length: 8442 atgattcctgccagatttgccggggtgctgcttgctctggccctcattttgccagggacc ctttgtgcagaaggaactcgcggcaggtcatccacggcccgatgcagccttttcggaagt gacttcgtcaacacctttgatgggagcatgtacagctttgcgggatactgcagttacctc ctggcagggggctgccagaaacgctccttctcgattattggggacttccagaatggcaag agagtgagcctctccgtgtatcttggggaattttttgacatccatttgtttgtcaatggt accgtgacacagggggaccaaagagtctccatgccctatgcctccaaagggctgtatcta gaaactgaggctgggtactacaagctgtccggtgaggcctatggctttgtggccaggatc gatggcagcggcaactttcaagtcctgctgtcagacagatacttcaacaagacctgcggg ctgtgtggcaactttaacatctttgctgaagatgactttatgacccaagaagggaccttg acctcggacccttatgactttgccaactcatgggctctgagcagtggagaacagtggtgt gaacgggcatctcctcccagcagctcatgcaacatctcctctggggaaatgcagaagggc ctgtgggagcagtgccagcttctgaagagcacctcggtgtttgcccgctgccaccctctg gtggaccccgagccttttgtggccctgtgtgagaagactttgtgtgagtgtgctgggggg ctggagtgcgcctgccctgccctcctggagtacgcccggacctgtgcccaggagggaatg gtgctgtacggctggaccgaccacagcgcgtgcagcccagtgtgccctgctggtatggag tataggcagtgtgtgtccccttgcgccaggacctgccagagcctgcacatcaatgaaatg tgtcaggagcgatgcgtggatggctgcagctgccctgagggacagctcctggatgaaggc ctctgcgtggagagcaccgagtgtccctgcgtgcattccggaaagcgctaccctcccggc acctccctctctcgagactgcaacacctgcatttgccgaaacagccagtggatctgcagc aatgaagaatgtccaggggagtgccttgtcacaggtcaatcacacttcaagagctttgac aacagatacttcaccttcagtgggatctgccagtacctgctggcccgggattgccaggac cactccttctccattgtcattgagactgtccagtgtgctgatgaccgcgacgctgtgtgc acccgctccgtcaccgtccggctgcctggcctgcacaacagccttgtgaaactgaagcat ggggcaggagttgccatggatggccaggacgtccagctccccctcctgaaaggtgacctc cgcatccagcatacagtgacggcctccgtgcgcctcagctacggggaggacctgcagatg gactgggatggccgcgggaggctgctggtgaagctgtcccccgtctatgccgggaagacc tgcggcctgtgtgggaattacaatggcaaccagggcgacgacttccttaccccctctggg ctggcggagccccgggtggaggacttcgggaacgcctggaagctgcacggggactgccag gacctgcagaagcagcacagcgatccctgcgccctcaacccgcgcatgaccaggttctcc gaggaggcgtgcgcggtcctgacgtcccccacattcgaggcctgccatcgtgccgtcagc ccgctgccctacctgcggaactgccgctacgacgtgtgctcctgctcggacggccgcgag tgcctgtgcggcgccctggccagctatgccgcggcctgcgcggggagaggcgtgcgcgtc gcgtggcgcgagccaggccgctgtgagctgaactgcccgaaaggccaggtgtacctgcag tgcgggaccccctgcaacctgacctgccgctctctctcttacccggatgaggaatgcaat gaggcctgcctggagggctgcttctgccccccagggctctacatggatgagaggggggac tgcgtgcccaaggcccagtgcccctgttactatgacggtgagatcttccagccagaagac atcttctcagaccatcacaccatgtgctactgtgaggatggcttcatgcactgtaccatg agtggagtccccggaagcttgctgcctgacgctgtcctcagcagtcccctgtctcatcgc agcaaaaggagcctatcctgtcggccccccatggtcaagctggtgtgtcccgctgacaac ctgcgggctgaagggctcgagtgtaccaaaacgtgccagaactatgacctggagtgcatg agcatgggctgtgtctctggctgcctctgccccccgggcatggtccggcatgagaacaga tgtgtggccctggaaaggtgtccctgcttccatcagggcaaggagtatgcccctggagaa acagtgaagattggctgcaacacttgtgtctgtcgggaccggaagtggaactgcacagac catgtgtgtgatgccacgtgctccacgatcggcatggcccactacctcaccttcgacggg ctcaaatacctgttccccggggagtgccagtacgttctggtgcaggattactgcggcagt aaccctgggacctttcggatcctagtggggaataagggatgcagccacccctcagtgaaa tgcaagaaacgggtcaccatcctggtggagggaggagagattgagctgtttgacggggag gtgaatgtgaagaggcccatgaaggatgagactcactttgaggtggtggagtctggccgg tacatcattctgctgctgggcaaagccctctccgtggtctgggaccgccacctgagcatc tccgtggtcctgaagcagacataccaggagaaagtgtgtggcctgtgtgggaattttgat ggcatccagaacaatgacctcaccagcagcaacctccaagtggaggaagaccctgtggac tttgggaactcctggaaagtgagctcgcagtgtgctgacaccagaaaagtgcctctggac tcatcccctgccacctgccataacaacatcatgaagcagacgatggtggattcctcctgt agaatccttaccagtgacgtcttccaggactgcaacaagctggtggaccccgagccatat ctggatgtctgcatttacgacacctgctcctgtgagtccattggggactgcgcctgcttc tgcgacaccattgctgcctatgcccacgtgtgtgcccagcatggcaaggtggtgacctgg aggacggccacattgtgcccccagagctgcgaggagaggaatctccgggagaacgggtat gagtgtgagtggcgctataacagctgtgcacctgcctgtcaagtcacgtgtcagcaccct gagccactggcctgccctgtgcagtgtgtggagggctgccatgcccactgccctccaggg aaaatcctggatgagcttttgcagacctgcgttgaccctgaagactgtccagtgtgtgag gtggctggccggcgttttgcctcaggaaagaaagtcaccttgaatcccagtgaccctgag cactgccagatttgccactgtgatgttgtcaacctcacctgtgaagcctgccaggagccg ggaggcctggtggtgcctcccacagatgccccggtgagccccaccactctgtatgtggag gacatctcggaaccgccgttgcacgatttctactgcagcaggctactggacctggtcttc ctgctggatggctcctccaggctgtccgaggctgagtttgaagtgctgaaggcctttgtg gtggacatgatggagcggctgcgcatctcccagaagtgggtccgcgtggccgtggtggag taccacgacggctcccacgcctacatcgggctcaaggaccggaagcgaccgtcagagctg cggcgcattgccagccaggtgaagtatgcgggcagccaggtggcctccaccagcgaggtc ttgaaatacacactgttccaaatcttcagcaagatcgaccgccctgaagcctcccgcatc accctgctcctgatggccagccaggagccccaacggatgtcccggaactttgtccgctac gtccagggcctgaagaagaagaaggtcattgtgatcccggtgggcattgggccccatgcc aacctcaagcagatccgcctcatcgagaagcaggcccctgagaacaaggccttcgtgctg agcagtgtggatgagctggagcagcaaagggacgagatcgttagctacctctgtgacctt gcccctgaagcccctcctcctactctgccccccgacatggcacaagtcactgtgggcccg gggctcttgggggtttcgaccctggggcccaagaggaactccatggttctggatgtggcg ttcgtcctggaaggatcggacaaaattggtgaagccgacttcaacaggagcaaggagttc atggaggaggtgattcagcggatggatgtgggccaggacagcatccacgtcacggtgctg cagtactcctacatggtgactgtggagtaccccttcagcgaggcacagtccaaaggggac atcctgcagcgggtgcgagagatccgctaccagggcggcaacaggaccaacactgggctg gccctgcggtacctctctgaccacagcttcttggtcagccagggtgaccgggagcaggcg cccaacctggtctacatggtcaccggaaatcctgcctctgatgagatcaagaggctgcct ggagacatccaggtggtgcccattggagtgggccctaatgccaacgtgcaggagctggag aggattggctggcccaatgcccctatcctcatccaggactttgagacgctcccccgagag gctcctgacctggtgctgcagaggtgctgctccggagaggggctgcagatccccaccctc tcccctgcacctgactgcagccagcccctggacgtgatccttctcctggatggctcctcc agtttcccagcttcttattttgatgaaatgaagagtttcgccaaggctttcatttcaaaa gccaatatagggcctcgtctcactcaggtgtcagtgctgcagtatggaagcatcaccacc attgacgtgccatggaacgtggtcccggagaaagcccatttgctgagccttgtggacgtc atgcagcgggagggaggccccagccaaatcggggatgccttgggctttgctgtgcgatac ttgacttcagaaatgcatggtgccaggccgggagcctcaaaggcggtggtcatcctggtc acggacgtctctgtggattcagtggatgcagcagctgatgccgccaggtccaacagagtg acagtgttccctattggaattggagatcgctacgatgcagcccagctacggatcttggca ggcccagcaggcgactccaacgtggtgaagctccagcgaatcgaagacctccctaccatg gtcaccttgggcaattccttcctccacaaactgtgctctggatttgttaggatttgcatg gatgaggatgggaatgagaagaggcccggggacgtctggaccttgccagaccagtgccac accgtgacttgccagccagatggccagaccttgctgaagagtcatcgggtcaactgtgac cgggggctgaggccttcgtgccctaacagccagtcccctgttaaagtggaagagacctgt ggctgccgctggacctgcccctgcgtgtgcacaggcagctccactcggcacatcgtgacc tttgatgggcagaatttcaagctgactggcagctgttcttatgtcctatttcaaaacaag gagcaggacctggaggtgattctccataatggtgcctgcagccctggagcaaggcagggc tgcatgaaatccatcgaggtgaagcacagtgccctctccgtcgagctgcacagtgacatg gaggtgacggtgaatgggagactggtctctgttccttacgtgggtgggaacatggaagtc aacgtttatggtgccatcatgcatgaggtcagattcaatcaccttggtcacatcttcaca ttcactccacaaaacaatgagttccaactgcagctcagccccaagacttttgcttcaaag acgtatggtctgtgtgggatctgtgatgagaacggagccaatgacttcatgctgagggat ggcacagtcaccacagactggaaaacacttgttcaggaatggactgtgcagcggccaggg cagacgtgccagcccatcctggaggagcagtgtcttgtccccgacagctcccactgccag gtcctcctcttaccactgtttgctgaatgccacaaggtcctggctccagccacattctat gccatctgccagcaggacagttgccaccaggagcaagtgtgtgaggtgatcgcctcttat gcccacctctgtcggaccaacggggtctgcgttgactggaggacacctgatttctgtgct atgtcatgcccaccatctctggtctacaaccactgtgagcatggctgtccccggcactgt gatggcaacgtgagctcctgtggggaccatccctccgaaggctgtttctgccctccagat aaagtcatgttggaaggcagctgtgtccctgaagaggcctgcactcagtgcattggtgag gatggagtccagcaccagttcctggaagcctgggtcccggaccaccagccctgtcagatc tgcacatgcctcagcgggcggaaggtcaactgcacaacgcagccctgccccacggccaaa gctcccacgtgtggcctgtgtgaagtagcccgcctccgccagaatgcagaccagtgctgc cccgagtatgagtgtgtgtgtgacccagtgagctgtgacctgcccccagtgcctcactgt gaacgtggcctccagcccacactgaccaaccctggcgagtgcagacccaacttcacctgc gcctgcaggaaggaggagtgcaaaagagtgtccccaccctcctgccccccgcaccgtttg cccacccttcggaagacccagtgctgtgatgagtatgagtgtgcctgcaactgtgtcaac tccacagtgagctgtccccttgggtacttggcctcaactgccaccaatgactgtggctgt accacaaccacctgccttcccgacaaggtgtgtgtccaccgaagcaccatctaccctgtg ggccagttctgggaggagggctgcgatgtgtgcacctgcaccgacatggaggatgccgtg atgggcctccgcgtggcccagtgctcccagaagccctgtgaggacagctgtcggtcgggc ttcacttacgttctgcatgaaggcgagtgctgtggaaggtgcctgccatctgcctgtgag gtggtgactggctcaccgcggggggactcccagtcttcctggaagagtgtcggctcccag tgggcctccccggagaacccctgcctcatcaatgagtgtgtccgagtgaaggaggaggtc tttatacaacaaaggaacgtctcctgcccccagctggaggtccctgtctgcccctcgggc tttcagctgagctgtaagacctcagcgtgctgcccaagctgtcgctgtgagcgcatggag gcctgcatgctcaatggcactgtcattgggcccgggaagactgtgatgatcgatgtgtgc acgacctgccgctgcatggtgcaggtgggggtcatctctggattcaagctggagtgcagg aagaccacctgcaacccctgccccctgggttacaaggaagaaaataacacaggtgaatgt tgtgggagatgtttgcctacggcttgcaccattcagctaagaggaggacagatcatgaca ctgaagcgtgatgagacgctccaggatggctgtgatactcacttctgcaaggtcaatgag agaggagagtacttctgggagaagagggtcacaggctgcccaccctttgatgaacacaag tgtctggctgagggaggtaaaattatgaaaattccaggcacctgctgtgacacatgtgag gagcctgagtgcaacgacatcactgccaggctgcagtatgtcaaggtgggaagctgtaag tctgaagtagaggtggatatccactactgccagggcaaatgtgccagcaaagccatgtac tccattgacatcaacgatgtgcaggaccagtgctcctgctgctctccgacacggacggag cccatgcaggtggccctgcactgcaccaatggctctgttgtgtaccatgaggttctcaat gccatggagtgcaaatgctcccccaggaagtgcagcaagtga |
Protein Sequence |
>7450 : length: 2813 MIPARFAGVLLALALILPGTLCAEGTRGRSSTARCSLFGSDFVNTFDGSMYSFAGYCSYL LAGGCQKRSFSIIGDFQNGKRVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYL ETEAGYYKLSGEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL TSDPYDFANSWALSSGEQWCERASPPSSSCNISSGEMQKGLWEQCQLLKSTSVFARCHPL VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSACSPVCPAGME YRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEGLCVESTECPCVHSGKRYPPG TSLSRDCNTCICRNSQWICSNEECPGECLVTGQSHFKSFDNRYFTFSGICQYLLARDCQD HSFSIVIETVQCADDRDAVCTRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDL RIQHTVTASVRLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSPTFEACHRAVS PLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRVAWREPGRCELNCPKGQVYLQ CGTPCNLTCRSLSYPDEECNEACLEGCFCPPGLYMDERGDCVPKAQCPCYYDGEIFQPED IFSDHHTMCYCEDGFMHCTMSGVPGSLLPDAVLSSPLSHRSKRSLSCRPPMVKLVCPADN LRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHENRCVALERCPCFHQGKEYAPGE TVKIGCNTCVCRDRKWNCTDHVCDATCSTIGMAHYLTFDGLKYLFPGECQYVLVQDYCGS NPGTFRILVGNKGCSHPSVKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGR YIILLLGKALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDPVD FGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVFQDCNKLVDPEPY LDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVVTWRTATLCPQSCEERNLRENGY ECEWRYNSCAPACQVTCQHPEPLACPVQCVEGCHAHCPPGKILDELLQTCVDPEDCPVCE VAGRRFASGKKVTLNPSDPEHCQICHCDVVNLTCEACQEPGGLVVPPTDAPVSPTTLYVE DISEPPLHDFYCSRLLDLVFLLDGSSRLSEAEFEVLKAFVVDMMERLRISQKWVRVAVVE YHDGSHAYIGLKDRKRPSELRRIASQVKYAGSQVASTSEVLKYTLFQIFSKIDRPEASRI TLLLMASQEPQRMSRNFVRYVQGLKKKKVIVIPVGIGPHANLKQIRLIEKQAPENKAFVL SSVDELEQQRDEIVSYLCDLAPEAPPPTLPPDMAQVTVGPGLLGVSTLGPKRNSMVLDVA FVLEGSDKIGEADFNRSKEFMEEVIQRMDVGQDSIHVTVLQYSYMVTVEYPFSEAQSKGD ILQRVREIRYQGGNRTNTGLALRYLSDHSFLVSQGDREQAPNLVYMVTGNPASDEIKRLP GDIQVVPIGVGPNANVQELERIGWPNAPILIQDFETLPREAPDLVLQRCCSGEGLQIPTL SPAPDCSQPLDVILLLDGSSSFPASYFDEMKSFAKAFISKANIGPRLTQVSVLQYGSITT IDVPWNVVPEKAHLLSLVDVMQREGGPSQIGDALGFAVRYLTSEMHGARPGASKAVVILV TDVSVDSVDAAADAARSNRVTVFPIGIGDRYDAAQLRILAGPAGDSNVVKLQRIEDLPTM VTLGNSFLHKLCSGFVRICMDEDGNEKRPGDVWTLPDQCHTVTCQPDGQTLLKSHRVNCD RGLRPSCPNSQSPVKVEETCGCRWTCPCVCTGSSTRHIVTFDGQNFKLTGSCSYVLFQNK EQDLEVILHNGACSPGARQGCMKSIEVKHSALSVELHSDMEVTVNGRLVSVPYVGGNMEV NVYGAIMHEVRFNHLGHIFTFTPQNNEFQLQLSPKTFASKTYGLCGICDENGANDFMLRD GTVTTDWKTLVQEWTVQRPGQTCQPILEEQCLVPDSSHCQVLLLPLFAECHKVLAPATFY AICQQDSCHQEQVCEVIASYAHLCRTNGVCVDWRTPDFCAMSCPPSLVYNHCEHGCPRHC DGNVSSCGDHPSEGCFCPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQI CTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHC ERGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDEYECACNCVN STVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAV MGLRVAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQ WASPENPCLINECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPSCRCERME ACMLNGTVIGPGKTVMIDVCTTCRCMVQVGVISGFKLECRKTTCNPCPLGYKEENNTGEC CGRCLPTACTIQLRGGQIMTLKRDETLQDGCDTHFCKVNERGEYFWEKRVTGCPPFDEHK CLAEGGKIMKIPGTCCDTCEEPECNDITARLQYVKVGSCKSEVEVDIHYCQGKCASKAMY SIDINDVQDQCSCCSPTRTEPMQVALHCTNGSVVYHEVLNAMECKCSPRKCSK |