| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 842 |
Name | CASP9 |
Synonym | APAF-3|APAF3|CASPASE-9c|ICE-LAP6|MCH6|PPP1R56;caspase 9, apoptosis-related cysteine peptidase;CASP9;caspase 9, apoptosis-related cysteine peptidase |
Definition | ICE-like apoptotic protease 6|apoptotic protease MCH-6|apoptotic protease activating factor 3|caspase-9|protein phosphatase 1, regulatory subunit 56 |
Position | 1p36.21 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells. |
| More detail of all Human literatures about CASP9 | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Formation of apoptosome;PID Reactome;500886 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Huntington's disease;KEGG PATHWAY;hsa05016 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | akt signaling pathway;PID BioCarta;100245 |
Pathway | hiv-1 nef: negative effector of fas and tnf;PID BioCarta;100144 |
Pathway | stress induction of hsp regulation;PID BioCarta;100142 |
Pathway | Amyotrophic lateral sclerosis (ALS);KEGG PATHWAY;hsa05014 |
Pathway | west nile virus;PID BioCarta;100001 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | internal ribosome entry pathway;PID BioCarta;100120 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | role of mitochondria in apoptotic signaling;PID BioCarta;100106 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | caspase cascade in apoptosis;PID BioCarta;100218 |
Pathway | regulation of cell cycle progression by plk3;PID BioCarta;100068 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | ras signaling pathway;PID BioCarta;100047 |
Pathway | apoptotic signaling in response to dna damage;PID BioCarta;100204 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | AKT phosphorylates targets in the cytosol;PID Reactome;500640 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Parkinson's disease;KEGG PATHWAY;hsa05012 |
Disease | Neuroblastoma;FunDO |
Disease | lung cancer;GAD |
Disease | Infection;FunDO |
Disease | Lung cancer;FunDO |
Disease | Reticulosarcoma;FunDO |
Disease | CANCER;GAD |
Disease | Brain tumor;FunDO |
Disease | Breast cancer;FunDO |
Disease | Adenovirus infection;FunDO |
Disease | Liver cancer;FunDO |
Disease | Parkinson disease;FunDO |
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External Links |
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Links to Entrez Gene | 842 |
Links to all GeneRIF Items | 842 |
Links to iHOP | 842 |
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Sequence Information |
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Nucleotide Sequence |
>842 : length: 1251 atggacgaagcggatcggcggctcctgcggcggtgccggctgcggctggtggaagagctg caggtggaccagctctgggacgccctgctgagccgcgagctgttcaggccccatatgatc gaggacatccagcgggcaggctctggatctcggcgggatcaggccaggcagctgatcata gatctggagactcgagggagtcaggctcttcctttgttcatctcctgcttagaggacaca ggccaggacatgctggcttcgtttctgcgaactaacaggcaagcagcaaagttgtcgaag ccaaccctagaaaaccttaccccagtggtgctcagaccagagattcgcaaaccagaggtt ctcagaccggaaacacccagaccagtggacattggttctggaggatttggtgatgtcggt gctcttgagagtttgaggggaaatgcagatttggcttacatcctgagcatggagccctgt ggccactgcctcattatcaacaatgtgaacttctgccgtgagtccgggctccgcacccgc actggctccaacatcgactgtgagaagttgcggcgtcgcttctcctcgctgcatttcatg gtggaggtgaagggcgacctgactgccaagaaaatggtgctggctttgctggagctggcg cagcaggaccacggtgctctggactgctgcgtggtggtcattctctctcacggctgtcag gccagccacctgcagttcccaggggctgtctacggcacagatggatgccctgtgtcggtc gagaagattgtgaacatcttcaatgggaccagctgccccagcctgggagggaagcccaag ctctttttcatccaggcctgtggtggggagcagaaagaccatgggtttgaggtggcctcc acttcccctgaagacgagtcccctggcagtaaccccgagccagatgccaccccgttccag gaaggtttgaggaccttcgaccagctggacgccatatctagtttgcccacacccagtgac atctttgtgtcctactctactttcccaggttttgtttcctggagggaccccaagagtggc tcctggtacgttgagaccctggacgacatctttgagcagtgggctcactctgaagacctg cagtccctcctgcttagggtcgctaatgctgtttcggtgaaagggatttataaacagatg cctggttgctttaatttcctccggaaaaaacttttctttaaaacatcataa |
Protein Sequence |
>842 : length: 416 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS |