| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 842 |
Name | CASP9 |
Synonymous | APAF-3|APAF3|CASPASE-9c|ICE-LAP6|MCH6|PPP1R56;caspase 9, apoptosis-related cysteine peptidase;CASP9;caspase 9, apoptosis-related cysteine peptidase |
Definition | ICE-like apoptotic protease 6|apoptotic protease MCH-6|apoptotic protease activating factor 3|caspase-9|protein phosphatase 1, regulatory subunit 56 |
Position | 1p36.21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr1:15817327-15853029 | chr1:15831460-15831460 | rs4646049 | Single_Nucleotides|eQTL|CASP9, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|FAIRE|Helas3 | chr1:15817327-15853029 | chr1:15834360-15834360 | rs2020902 | Single_Nucleotides|eQTL|CASP9, Chromatin_Structure|DNase-seq|Ips |
|---|---|---|---|
Transcription Factors [Top] |
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Regulation From TransFac database |
proCaspase-9(h) --Cytochrome C(h):Apaf-1(h):dATP--> Caspase-9(h) (processing) | proCaspase-9(h) --CARD4(h)--> Caspase-9(h) (processing) | proCaspase-9(h) --Apaf-1(h)--> Caspase-9(h) (processing) | Apaf-1(h) + proCaspase-9(h) <==> Apaf-1(h):proCaspase-9(h) (binding) | proCaspase-9(h) --Apaf-1L(h):dATP:Cytochrome C(b)--> Caspase-9-p35(h) + protein remnants (processing) | proCaspase-9(h) + proCaspase-9(h) <==> (proCaspase-9(h))2 (binding) | Apaf-1(h) + proCaspase-9(h) + proCaspase-3(h) <==> Apaf-1(h):proCaspase-9(h):proCaspase-3(h) (binding) | proCaspase-9(h) --Caspase-3(h)--> Caspase-9-p10(h) + Caspase-9-p35(h) (processing) | proCaspase-9(h) --granzymeB(h)--> Caspase-9-p35(h) + Caspase-9-p10(h) (processing) | proCaspase-9(h) + ATP --AKT(v.s.){pT308}{pS473}--> proCaspase-9(h){pS196} + ADP (phosphorylation) | proCaspase-9(h) + RIP3(h) <==> proCaspase-9(h):RIP3(h) (binding) | proCaspase-3(h) + XIAP(h) + Cytochrome C(h) + Apaf-1(h) + proCaspase-9(h) <==> proCaspase-3(h):XIAP(h):Cytochrome C(h):Apaf-1(h):proCaspase-9(h) (binding) | proCaspase-9(h) --Caspase-10(h)--> Caspase-9-p10(h) + protein remnants (processing) | proCaspase-9(h) --Caspase-8(h)--> Caspase-9-p35(h) + Caspase-9-p10(h) + protein remnants (processing) | proCaspase-9(h) --> Caspase-9(h) (cleavage) | proCaspase-9(h) + Abl(h) <==> proCaspase-9(h):Abl(h) (binding) | proCaspase-9(h) + ATP --Abl(h)--> proCaspase-9(h){pY153} + ADP (phosphorylation) | proCaspase-9(h) --> Caspase-9-p37(h) + protein remnants (processing) | proCaspase-9(h) --> Caspase-9-p35(h) + protein remnants (processing) | proCaspase-9(h) --Caspase-3(m.s.)--> Caspase-9-p37(h) + protein remnants (processing) | proCaspase-9(h) --Caspase-3(m.s.)--> Caspase-9-p35(h) + protein remnants (cleavage) | proCaspase-9(h) + GMEB-1(h) <==> proCaspase-9(h):GMEB-1(h) (binding) | proCaspase-9(h) + GMEB1-xbb2(h) <==> proCaspase-9(h):GMEB1-xbb2(h) (binding) | proCaspase-2(h) + proCaspase-9(h) + Apaf-1(h) + proCaspase-3(h) <==> proCaspase-2(h):proCaspase-9(h):Apaf-1(h):proCaspase-3(h) (binding) | proCaspase-9(h) --> Caspase-9-p34(h) + protein remnants (cleavage) | proCaspase-9(h) + cIAP-1(m.s.) <==> proCaspase-9(h):cIAP-1(m.s.) (binding) | proCaspase-9(h) + cIAP-2(h) <==> proCaspase-9(h):cIAP-2(h) (binding) | proCaspase-9(h) --> protein remnants (processing) | proCaspase-9(h) --Caspase-3(h)--> Caspase-9-p37(h) + protein remnants (processing) | proCaspase-9(h) --Caspase-8(h)--> Caspase-9-p37(h) + protein remnants (processing) | proCaspase-9(h) --Caspase-8(h)--> Caspase-9-p35(h) + protein remnants (processing) | proCaspase-9(h) --Caspase-3(h)--> Caspase-9-p37(h) + Caspase-9-p10(h) (processing) | proCaspase-9(h) --> Caspase-9-p36(h) + protein remnants (processing) | proCaspase-9(h) + ATP --> proCaspase-9(h){pT125} + ADP (phosphorylation) | proCaspase-9(h) --> Caspase-9-p17(h) + protein remnants (cleavage; automodification) | CASP9(h) --> proCaspase-9(h) (expression). | CASP9(h) --> proCaspase-9beta(h) (expression). | proCaspase-9alpha(h) --> Capase-9alpha-p37(h) + Caspase-9alpha-p10(h) (cleavage) | CASP9(h) --> proCaspase-9alpha(h) (expression). | proCaspase-9gamma(h) --> Caspase-3-p17(h) (decrease of cleavage) | proCaspase-9gamma(h) --> PARP-p89(h) (decrease of cleavage) | CASP9(h) --> proCaspase-9gamma(h) (expression). | CASP9(h) --> CASP9(h) (expression). | hsa-miR-133a --/ CASP9(h) (increase of mRNA decay). | hsa-miR-133b --/ CASP9(h) (increase of mRNA decay). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
125 | Phosphothreonine (MAP2K1;MAP2K) | 12792650 | Phospho.ELM 6.0 | 153 | Phosphotyrosine (Abl) | 15657060 | Phospho.ELM 6.0 | 183 | Phosphoserine | 15703181 | Phospho.ELM 6.0 | 144 | Phosphoserine (PKC zeta) | 16287866 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr1 |
Promoter: 15722877 - 15724877 | GSE27584 |
chr1 |
Promoter: 15722877 - 15724877 | GSE27584 |
chr1 |
Promoter: 15722877 - 15724877 | Agilent_014791_44K |
chr1 |
Promoter: 15722877 - 15724877 | Agilent_014791 |