| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 8600 |
Name | TNFSF11 |
Synonym | CD254|ODF|OPGL|OPTB2|RANKL|TRANCE|hRANKL2|sOdf;tumor necrosis factor (ligand) superfamily, member 11;TNFSF11;tumor necrosis factor (ligand) superfamily, member 11 |
Definition | TNF-related activation-induced cytokine|osteoclast differentiation factor|osteoprotegerin ligand|receptor activator of nuclear factor kappa B ligand|receptor activator of nuclear factor kappa-B ligand|tumor necrosis factor ligand superfamily member 11 |
Position | 13q14 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension. |
| More detail of all Human literatures about TNFSF11 | |
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Pathways and Diseases |
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Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | bone remodeling;PID BioCarta;100052 |
Disease | Osteopetrosis, autosomal recessive 2;OMIM |
Disease | Bone mineral density (spine);NHGRI |
Disease | Bone mineral density (hip);NHGRI |
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External Links |
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Links to Entrez Gene | 8600 |
Links to all GeneRIF Items | 8600 |
Links to iHOP | 8600 |
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Sequence Information |
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Nucleotide Sequence |
>8600 : length: 954 atgcgccgcgccagcagagactacaccaagtacctgcgtggctcggaggagatgggcggc ggccccggagccccgcacgagggccccctgcacgccccgccgccgcctgcgccgcaccag ccccctgccgcctcccgctccatgttcgtggccctcctggggctggggctgggccaggtt gtctgcagcgtcgccctgttcttctatttcagagcgcagatggatcctaatagaatatca gaagatggcactcactgcatttatagaattttgagactccatgaaaatgcagattttcaa gacacaactctggagagtcaagatacaaaattaatacctgattcatgtaggagaattaaa caggcctttcaaggagctgtgcaaaaggaattacaacatatcgttggatcacagcacatc agagcagagaaagcgatggtggatggctcatggttagatctggccaagaggagcaagctt gaagctcagccttttgctcatctcactattaatgccaccgacatcccatctggttcccat aaagtgagtctgtcctcttggtaccatgatcggggttgggccaagatctccaacatgact tttagcaatggaaaactaatagttaatcaggatggcttttattacctgtatgccaacatt tgctttcgacatcatgaaacttcaggagacctagctacagagtatcttcaactaatggtg tacgtcactaaaaccagcatcaaaatcccaagttctcataccctgatgaaaggaggaagc accaagtattggtcagggaattctgaattccatttttattccataaacgttggtggattt tttaagttacggtctggagaggaaatcagcatcgaggtctccaacccctccttactggat ccggatcaggatgcaacatactttggggcttttaaagttcgagatatagattga |
Protein Sequence |
>8600 : length: 317 MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQV VCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIK QAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSH KVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMV YVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLD PDQDATYFGAFKVRDID |