Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	8600
Name	TNFSF11
Synonymous	CD254\|ODF\|OPGL\|OPTB2\|RANKL\|TRANCE\|hRANKL2\|sOdf;tumor necrosis factor (ligand) superfamily, member 11;TNFSF11;tumor necrosis factor (ligand) superfamily, member 11
Definition	TNF-related activation-induced cytokine\|osteoclast differentiation factor\|osteoprotegerin ligand\|receptor activator of nuclear factor kappa B ligand\|receptor activator of nuclear factor kappa-B ligand\|tumor necrosis factor ligand superfamily member 11
Position	13q14
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB [Top]
	There is no record for TNFSF11

Regulation From TransFac database
Transcription Factors [Top]
RANKL-2(h) + RANK(h) <==> RANKL-2(h):RANK(h) (binding)
RANKL-2(h) + RANK(m) <==> RANKL-2(h):RANK(m) (binding)
RANKL-2(h) + OPG(m) <==> RANKL-2(h):OPG(m) (binding)
RANKL-2(h) + OPG(h) <==> RANKL-2(h):OPG(h) (binding)
RANKL-2(h) --> Ctsk(m) (transactivation)
RANKL-2(h) --> CTSK(h) (transactivation)
RANKL-2(h) --> p38(m){p} (increase of phosphorylation)
RANKL-2(h) --> Nfatc1(m) (transactivation)
TNFSF11(h) --> RANKL-2(h) (expression).
TNFSF11(h) --> RANKL-1(h) (expression).
RANKL(h) + RANK(m.s.) <==> RANKL(h):RANK(m.s.) (binding)
OPG(h) + RANKL(h) <==> OPG(h):RANKL(h) (binding)
TNFSF11(h) --> RANKL(h) (expression).
TNFSF11(h) --> RANKL-3(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
171	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
198	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr13	Promoter: 42044798 - 42046798	Agilent_014791
chr13	Promoter: 42044798 - 42046798	GSE27584
chr13	Promoter: 42044798 - 42046798	Agilent_014791_44K

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