| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 9475 |
Name | ROCK2 |
Synonym | ROCK-II;Rho-associated, coiled-coil containing protein kinase 2;ROCK2;Rho-associated, coiled-coil containing protein kinase 2 |
Definition | p164 ROCK-2|rho-associated protein kinase 2|rho-associated, coiled-coil-containing protein kinase II |
Position | 2p24 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Activation of the small GTPase Ras homolog gene family member A (RhoA) and Rho-associated kinase (ROCK) are important in the pathogenesis of pulmonary arterial hypertension (PAH). |
PAH | Activation of the small GTPase Ras homolog gene family member A (RhoA) and Rho-associated kinase (ROCK) are important in the pathogenesis of pulmonary arterial hypertension (PAH). |
| More detail of all Rat literatures about ROCK2 | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | ccr3 signaling in eosinophils;PID BioCarta;100215 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | Shigellosis;KEGG PATHWAY;hsa05131 |
Pathway | PLK1 signaling events;PID Curated;200087 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Osteopontin-mediated events;PID Curated;200042 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Cytoskeletal regulation by Rho GTPase;PANTHER;P00016 |
Disease | Scleroderma;FunDO |
Disease | hypertension;GAD |
Disease | Hypertension;FunDO |
Disease | Systemic scleroderma;FunDO |
Disease | CARDIOVASCULAR;GAD |
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External Links |
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Links to Entrez Gene | 9475 |
Links to all GeneRIF Items | 9475 |
Links to iHOP | 9475 |
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Sequence Information |
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Nucleotide Sequence |
>9475 : length: 4167 atgagccggcccccgccgacggggaaaatgcccggcgcccccgagaccgcgccgggggac ggggcaggcgcgagccgccagaggaagctggaggcgctgatccgagaccctcgctccccc atcaacgtggagagcttgctggatggcttaaattccttggtccttgatttagattttcct gctttgaggaaaaacaagaacatagataatttcttaaatagatatgagaaaattgtgaaa aaaatcagaggtctacagatgaaggcagaagactatgatgttgtaaaagttattggaaga ggtgcttttggtgaagtgcagttggttcgtcacaaggcatcgcagaaggtttatgctatg aagcttcttagtaagtttgaaatgataaaaagatcagattctgcctttttttgggaagaa agagatattatggcctttgccaatagcccctgggtggttcagcttttttatgcctttcaa gatgataggtatctgtacatggtaatggagtacatgcctggtggagaccttgtaaacctt atgagtaattatgatgtgcctgaaaaatgggccaaattttacactgctgaagttgttctt gctctggatgcaatacactccatgggtttaatacacagagatgtgaagcctgacaacatg ctcttggataaacatggacatctaaaattagcagattttggcacgtgtatgaagatggat gaaacaggcatggtacattgtgatacagcagttggaacaccggattatatatcacctgag gttctgaaatcacaagggggtgatggtttctatgggcgagaatgtgattggtggtctgta ggtgttttcctttatgagatgctagtgggggatactccattttatgcggattcacttgta ggaacatatagcaaaattatggatcataagaattcactgtgtttccctgaagatgcagaa atttccaaacatgcaaagaatctcatctgtgctttcttaacagatagggaggtacgactt gggagaaatggggtggaagaaatcagacagcatcctttctttaagaatgatcagtggcat tgggataacataagagaaacggcagctcctgtagtacctgaactcagcagtgacatagac agcagcaatttcgatgacattgaagatgacaaaggagatgtagaaaccttcccaattcct aaagcttttgttggaaatcagctgcctttcatcggatttacctactatagagaaaattta ttattaagtgactctccatcttgtagagaaactgattccatacaatcaaggaaaaatgaa gaaagtcaagagattcagaaaaaactgtatacattagaagaacatcttagcaatgagatg caagccaaagaggaactggaacagaagtgcaaatctgttaatactcgcctagaaaaaaca gcaaaggagctagaagaggagattaccttacggaaaagtgtggaatcagcattaagacag ttagaaagagaaaaggcgcttcttcagcacaaaaatgcagaatatcagaggaaagctgat catgaagcagacaaaaaacgaaatttggaaaatgatgttaacagcttaaaagatcaactt gaagatttgaaaaaaagaaatcaaaactctcaaatatccactgagaaagtgaatcaactc cagagacaactggatgaaaccaatgctttactgcgaacagagtctgatactgcagcccgg ttaaggaaaacccaggcagaaagttcaaaacagattcagcagctggaatctaacaataga gatctacaagataaaaactgcctgctggagactgccaagttaaaacttgaaaaggaattt atcaatcttcagtcagctctagaatctgaaaggagggatcgaacccatggatcagagata attaatgatttacaaggtagaatatgtggcctagaagaagatttaaagaacggcaaaatc ttactagcgaaagtagaactggagaagagacaacttcaggagagatttactgatttggaa aaggaaaaaagcaacatggaaatagatatgacataccaactaaaagttatacagcagagc ctagaacaagaagaagctgaacataaggccacaaaggcacgactagcagataaaaataag atctatgagtccatcgaagaagccaaatcagaagccatgaaagaaatggagaagaagctc ttggaggaaagaactttaaaacagaaagtggagaacctattgctagaagctgagaaaaga tgttctctattagactgtgacctcaaacagtcacagcagaaaataaatgagctccttaaa cagaaagatgtgctaaatgaggatgttagaaacctgacattaaaaatagagcaagaaact cagaagcgctgccttacacaaaatgacctgaagatgcaaacacaacaggttaacacacta aaaatgtcagaaaagcagttaaagcaagaaaataaccatctcatggaaatgaaaatgaac ttggaaaaacaaaatgctgaacttcgaaaagaacgtcaggatgcagatgggcaaatgaaa gagctccaggatcagctcgaagcagaacagtatttctcaaccctttataaaacacaagtt agggagcttaaagaagaatgtgaagaaaagaccaaacttggtaaagaattgcagcagaag aaacaggaattacaggatgaacgggactctttggctgcccaactggagatcaccttgacc aaagcagattctgagcaactggctcgttcaattgctgaagaacaatattctgatttggaa aaagagaagatcatgaaagagctggagatcaaagagatgatggctagacacaaacaggaa cttacggaaaaagatgctacaattgcttctcttgaggaaactaataggacactaactagt gatgttgccaatcttgcaaatgagaaagaagaattaaataacaaattgaaagatgttcaa gagcaactgtcaagattgaaagatgaagaaataagcgcagcagctattaaagcacagttt gagaagcagctattaacagaaagaacactcaaaactcaagctgtgaataagttggctgag atcatgaatcgaaaagaacctgtcaagcgtggtaatgacacagatgtgcggagaaaagag aaggagaatagaaagctacatatggagcttaaatctgaacgtgagaaattgacccagcag atgatcaagtatcagaaagaactgaatgaaatgcaggcacaaatagctgaagagagccag attcgaattgaactgcagatgacattggacagtaaagacagtgacattgagcagctgcgg tcacaactccaagccttgcatattggtctggatagttccagtataggcagtggaccaggg gatgctgaggcagatgatgggtttccagaatcaagattagaaggatggctttcattgcct gtacgaaacaacactaagaaatttggatgggttaaaaagtatgtgattgtaagcagtaag aagattcttttctatgacagtgaacaagataaagaacaatccaatccttacatggtttta gatatagacaagttatttcatgtccgaccagttacacagacagatgtgtatagagcagat gctaaagaaattccaaggatattccagattctgtatgccaatgaaggagaaagtaagaag gaacaagaatttccagtggagccagttggagaaaaatctaattatatttgccacaaggga catgagtttattcctactctttatcatttcccaaccaactgtgaggcttgtatgaagccc ctgtggcacatgtttaagcctcctcctgctttggagtgccgccgttgccatattaagtgt cataaagatcatatggacaaaaaggaggagattatagcaccttgcaaagtatattatgat atttcaacggcaaagaatctgttattactagcaaattctacagaagagcagcagaagtgg gttagtcggttggtgaaaaagatacctaaaaagcccccagctccagacccttttgcccga tcatctcctagaacttcaatgaagatacagcaaaaccagtctattagacggccaagtcga cagcttgccccaaacaaacctagctaa |
Protein Sequence |
>9475 : length: 1388 MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR DLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKI LLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNK IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLK QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMN LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQK KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQF EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG DAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD ISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR QLAPNKPS |