| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 9518 |
Name | GDF15 |
Synonym | GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB;growth differentiation factor 15;GDF15;growth differentiation factor 15 |
Definition | NRG-1|NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1|NSAID-activated gene 1 protein|NSAID-regulated gene 1 protein|PTGF-beta|growth/differentiation factor 15|macrophage inhibitory cytokine 1|placental TGF-beta|placental bone morphogenetic |
Position | 19p13.11 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells. |
| More detail of all Human literatures about GDF15 | |
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Pathways and Diseases |
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Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Disease | hypertension;GAD |
Disease | Hypertrophy, Left Ventricular;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Ventricular Remodeling;GAD |
Disease | Thalassemia;FunDO |
Disease | Cancer;FunDO |
Disease | Depression;FunDO |
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External Links |
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Links to Entrez Gene | 9518 |
Links to all GeneRIF Items | 9518 |
Links to iHOP | 9518 |
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Sequence Information |
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Nucleotide Sequence |
>9518 : length: 927 atgcccgggcaagaactcaggacggtgaatggctctcagatgctcctggtgttgctggtg ctctcgtggctgccgcatgggggcgccctgtctctggccgaggcgagccgcgcaagtttc ccgggaccctcagagttgcactccgaagactccagattccgagagttgcggaaacgctac gaggacctgctaaccaggctgcgggccaaccagagctgggaagattcgaacaccgacctc gtcccggcccctgcagtccggatactcacgccagaagtgcggctgggatccggcggccac ctgcacctgcgtatctctcgggccgcccttcccgaggggctccccgaggcctcccgcctt caccgggctctgttccggctgtccccgacggcgtcaaggtcgtgggacgtgacacgaccg ctgcggcgtcagctcagccttgcaagaccccaggcgcccgcgctgcacctgcgactgtcg ccgccgccgtcgcagtcggaccaactgctggcagaatcttcgtccgcacggccccagctg gagttgcacttgcggccgcaagccgccagggggcgccgcagagcgcgtgcgcgcaacggg gaccactgtccgctcgggcccgggcgttgctgccgtctgcacacggtccgcgcgtcgctg gaagacctgggctgggccgattgggtgctgtcgccacgggaggtgcaagtgaccatgtgc atcggcgcgtgcccgagccagttccgggcggcaaacatgcacgcgcagatcaagacgagc ctgcaccgcctgaagcccgacacggtgccagcgccctgctgcgtgcccgccagctacaat cccatggtgctcattcaaaagaccgacaccggggtgtcgctccagacctatgatgacttg ttagccaaagactgccactgcatatga |
Protein Sequence |
>9518 : length: 308 MPGQELRTVNGSQMLLVLLVLSWLPHGGALSLAEASRASFPGPSELHSEDSRFRELRKRY EDLLTRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRL HRALFRLSPTASRSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQL ELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMC IGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDL LAKDCHCI |