| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 9518 |
Name | GDF15 |
Synonymous | GDF-15|MIC-1|MIC1|NAG-1|PDF|PLAB|PTGFB;growth differentiation factor 15;GDF15;growth differentiation factor 15 |
Definition | NRG-1|NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1|NSAID-activated gene 1 protein|NSAID-regulated gene 1 protein|PTGF-beta|growth/differentiation factor 15|macrophage inhibitory cytokine 1|placental TGF-beta|placental bone morphogenetic |
Position | 19p13.11 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr19:18485541-18499987 | chr19:18499815-18499815 | rs1054564 | Single_Nucleotides|eQTL|CRLF2, Single_Nucleotides|eQTL|LRRC25, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Cll, Chromatin_Structure|DNase-seq|Medullo, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Gm19239, Protein_Binding|ChIP-seq|CREBBP, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|GATA1 |
|---|---|---|---|
Transcription Factors [Top] |
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Regulation From TransFac database |
MIC-1(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | MIC-1(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | MIC-1(h) --> AKT-1(h){pS473} (increase of phosphorylation) | GDF15(h) --> MIC-1(h) (expression). | GDF15(h) --> MIC-1(h) (expression). | p53(h) --> MIC-1(h) (increase of abundance) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
70 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
There is no record for GDF15 | ||