| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 959 |
Name | CD40LG |
Synonym | CD154|CD40L|HIGM1|IGM|IMD3|T-BAM|TNFSF5|TRAP|gp39|hCD40L;CD40 ligand;CD40LG;CD40 ligand |
Definition | CD40 antigen ligand|CD40-L|T-B cell-activating molecule|T-cell antigen Gp39|TNF-related activation protein|tumor necrosis factor (ligand) superfamily member 5 |
Position | Xq26 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Soluble CD40 ligand in pulmonary arterial hypertension: possible pathogenic role of the interaction between platelets and endothelial cells. |
| More detail of all Human literatures about CD40LG | |
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Pathways and Diseases |
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Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Malaria;KEGG PATHWAY;hsa05144 |
Pathway | Allograft rejection;KEGG PATHWAY;hsa05330 |
Pathway | Asthma;KEGG PATHWAY;hsa05310 |
Pathway | Viral myocarditis;KEGG PATHWAY;hsa05416 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | cd40l signaling pathway;PID BioCarta;100213 |
Pathway | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477 |
Pathway | Systemic lupus erythematosus;KEGG PATHWAY;hsa05322 |
Pathway | Calcium signaling in the CD4+ TCR pathway;PID Curated;200159 |
Pathway | Primary immunodeficiency;KEGG PATHWAY;hsa05340 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Autoimmune thyroid disease;KEGG PATHWAY;hsa05320 |
Pathway | Intestinal immune network for IgA production;KEGG PATHWAY;hsa04672 |
Disease | Combined immunodeficiencies;KEGG DISEASE;H00093 |
Disease | hyper-IgM syndrome can form oligomers and trigger CD40-mediated signals;GAD |
Disease | IMMUNE;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | lupus erythematosus;GAD |
Disease | systemic lupus erythematosus;GAD |
Disease | Immunodeficiency, X-linked, with hyper-IgM;OMIM |
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External Links |
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Links to Entrez Gene | 959 |
Links to all GeneRIF Items | 959 |
Links to iHOP | 959 |
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Sequence Information |
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Nucleotide Sequence |
>959 : length: 786 atgatcgaaacatacaaccaaacttctccccgatctgcggccactggactgcccatcagc atgaaaatttttatgtatttacttactgtttttcttatcacccagatgattgggtcagca ctttttgctgtgtatcttcatagaaggttggacaagatagaagatgaaaggaatcttcat gaagattttgtattcatgaaaacgatacagagatgcaacacaggagaaagatccttatcc ttactgaactgtgaggagattaaaagccagtttgaaggctttgtgaaggatataatgtta aacaaagaggagacgaagaaagaaaacagctttgaaatgcaaaaaggtgatcagaatcct caaattgcggcacatgtcataagtgaggccagcagtaaaacaacatctgtgttacagtgg gctgaaaaaggatactacaccatgagcaacaacttggtaaccctggaaaatgggaaacag ctgaccgttaaaagacaaggactctattatatctatgcccaagtcaccttctgttccaat cgggaagcttcgagtcaagctccatttatagccagcctctgcctaaagtcccccggtaga ttcgagagaatcttactcagagctgcaaatacccacagttccgccaaaccttgcgggcaa caatccattcacttgggaggagtatttgaattgcaaccaggtgcttcggtgtttgtcaat gtgactgatccaagccaagtgagccatggcactggcttcacgtcctttggcttactcaaa ctctga |
Protein Sequence |
>959 : length: 261 MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLH EDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNP QIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSN REASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVN VTDPSQVSHGTGFTSFGLLKL |