| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 993 |
Name | CDC25A |
Synonym | CDC25A2;cell division cycle 25A;CDC25A;cell division cycle 25A |
Definition | CDC25A2-CAG isoform|M-phase inducer phosphatase 1|dual specificity phosphatase CDC25A |
Position | 3p21 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "We observed linkage evidence in four regions: 3q22 ([median log of the odds (LOD) = 3.43]), 3p12 (median LOD) = 2.35), 2p22 (median LOD = 2.21), and 13q21 (median LOD = 2.09). When used in conjunction with the non-parametric bootstrap, our approach yields high-resolution to identify candidate gene regions containing putative BMPR2-interacting genes. Imputation of the disease model by LOD-score maximization indicates that the 3q22 locus alone predicts most FPAH cases in BMPR2 mutation carriers, providing strong evidence that BMPR2 and the 3q22 locus interact epistatically." |
| More detail of all Human literatures about CDC25A | |
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Pathways and Diseases |
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Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | Activation of ATR in response to replication stress;PID Reactome;500319 |
Pathway | cyclins and cell cycle regulation;PID BioCarta;100207 |
Pathway | p53-Independent DNA Damage Response;PID Reactome;500994 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | Ubiquitin Mediated Degradation of Phosphorylated Cdc25A;PID Reactome;500938 |
Pathway | Cyclin A:Cdk2-associated events at S phase entry;PID Reactome;500375 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Pathway | Cyclin E associated events during G1/S transition;PID Reactome;500877 |
Disease | altered cell-cycle;GAD |
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External Links |
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Links to Entrez Gene | 993 |
Links to all GeneRIF Items | 993 |
Links to iHOP | 993 |
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Sequence Information |
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Nucleotide Sequence |
>993 : length: 1575 atggaactgggcccggagcccccgcaccgccgccgcctgctcttcgcctgcagcccccct cccgcgtcgcagcccgtcgtgaaggcgctatttggcgcttcagccgccgggggactgtcg cctgtcaccaacctgaccgtcactatggaccagctgcagggtctgggcagtgattatgag caaccactggaggtgaagaacaacagtaatctgcagagaatgggctcctccgagtcaaca gattcaggtttctgtctagattctcctgggccattggacagtaaagaaaaccttgaaaat cctatgagaagaatacattccctacctcagaagctgttgggatgtagtccagctctgaag aggagccattctgattctcttgaccatgacatctttcagctcatcgacccagatgagaac aaggaaaatgaagcctttgagtttaagaagccagtaagacctgtatctcgtggctgcctg cactctcatggactccaggagggtaaagatctcttcacacagaggcagaactctgcccca gctcggatgctttcctcaaatgaaagagatagcagtgaaccagggaatttcattcctctt tttacaccccagtcacctgtgacagccactttgtctgatgaggatgatggcttcgtggac cttctcgatggagagaatctgaagaatgaggaggagaccccctcgtgcatggcaagcctc tggacagctcctctcgtcatgagaactacaaaccttgacaaccgatgcaagctgtttgac tccccttccctgtgtagctccagcactcggtcagtgttgaagagaccagaacgatctcaa gaggagtctccacctggaagtacaaagaggaggaagagcatgtctggggccagccccaaa gagtcaactaatccagagaaggcccatgagactcttcatcagtctttatccctggcatct tcccccaaaggaaccattgagaacattttggacaatgacccaagggaccttataggagac ttctccaagggttatctctttcatacagttgctgggaaacatcaggatttaaaatacatc tctccagaaattatggcatctgttttgaatggcaagtttgccaacctcattaaagagttt gttatcatcgactgtcgatacccatatgaatacgagggaggccacatcaagggtgcagtg aacttgcacatggaagaagaggttgaagacttcttattgaagaagcccattgtacctact gatggcaagcgtgtcattgttgtgtttcactgcgagttttcttctgagagaggtccccgc atgtgccggtatgtgagagagagagatcgcctgggtaatgaataccccaaactccactac cctgagctgtatgtcctgaaggggggatacaaggagttctttatgaaatgccagtcttac tgtgagccccctagctaccggcccatgcaccacgaggactttaaagaagacctgaagaag ttccgcaccaagagccggacctgggcaggggagaagagcaagagggagatgtacagtcgt ctgaagaagctctga |
Protein Sequence |
>993 : length: 524 MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYE QPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALK RSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAP ARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASL WTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPK ESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYI SPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPT DGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSY CEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL |