| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 993 |
Name | CDC25A |
Synonymous | CDC25A2;cell division cycle 25A;CDC25A;cell division cycle 25A |
Definition | CDC25A2-CAG isoform|M-phase inducer phosphatase 1|dual specificity phosphatase CDC25A |
Position | 3p21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr3:48198636-48229892 | chr3:48228994-48228994 | rs3729577 | Single_Nucleotides|eQTL|ZNF589, Single_Nucleotides|eQTL|ZNF589, Single_Nucleotides|eQTL|ZNF589, Single_Nucleotides|eQTL|ZNF589, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Gm06990, Chromatin_Structure|DNase-seq|Cmk |
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Transcription Factors [Top] |
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Regulation From TransFac database |
cyclinD1(h) + Cdc25A(h) <==> cyclinD1(h):Cdc25A(h) (binding) | cyclinE(h) + Cdc25A(h) <==> cyclinE(h):Cdc25A(h) (binding) | cyclinA(h) + Cdc25A(h) <==> cyclinA(h):Cdc25A(h) (binding) | cyclinB(h) + Cdc25A(h) <==> cyclinB(h):Cdc25A(h) (binding) | cyclinE(h):Cdk2(h){pY15} + Cdc25A(h) <==> cyclinE(h):Cdk2(h){pY15}:Cdc25A(h) (binding) | cyclinA(h):Cdk2(h) + Cdc25A(h) <==> cyclinA(h):Cdk2(h):Cdc25A(h) (binding) | Cdc25A(h) + 14-3-3beta(h) <==> Cdc25A(h):14-3-3beta(h) (binding) | Cdc25A(h) + 14-3-3epsilon(h) <==> Cdc25A(h):14-3-3epsilon(h) (binding) | Cdc25A(h) + 14-3-3beta(h) + Raf-1(h) <==> Cdc25A(h):14-3-3beta(h):Raf-1(h) (binding) | Cdc25A(h) + Chk1(h) <==> Cdc25A(h):Chk1(h) (binding) | ASK1(h) + Cdc25A(h) <==> ASK1(h):Cdc25A(h) (binding) | Raf-1(h) + Cdc25A(h) <==> Raf-1(h):Cdc25A(h) (binding) | Cdc25A(h) + ATP --Chk2(h)--> Cdc25A(h){p} + ADP (phosphorylation) | ErbB1(h) + Cdc25A(h) <==> ErbB1(h):Cdc25A(h) (binding) | ErbB1(h){pY} + Cdc25A(h) <==> ErbB1(h){pY}:Cdc25A(h) (binding) | Cdc25A(h) + n ubiquitin(b) --E1(h),E2-C(SPISO),cyclosome(h):Fzr(h)--> Cdc25A(h){ub(n)} (ubiquitination) | Skp1(h) + Cdc25A(h) <==> Skp1(h):Cdc25A(h) (binding) | Cul-1(h) + Cdc25A(h) <==> Cul-1(h):Cdc25A(h) (binding) | Cul-1(h){nedd} + Cdc25A(h) <==> Cul-1(h){nedd}:Cdc25A(h) (binding) | beta-TrCP1(h) + Cdc25A(h) <==> beta-TrCP1(h):Cdc25A(h) (binding) | HOS(h) + Cdc25A(h) <==> HOS(h):Cdc25A(h) (binding) | Cdc25A(h) + 2 ATP --Chk1(v.s.)--> Cdc25A(h){pS75}{pS123} + 2 ADP (phosphorylation) | Cdc25A(h) + Smad3(h) <==> Cdc25A(h):Smad3(h) (binding) | Cdc25A(h) + 2 ATP --> Cdc25A(h){pS82}{pS88} + 2 ADP (phosphorylation) | Cdc25A(h) --> protein remnants (degradation) | Cdc25A(h) + 2 ATP --Cdk1-isoform1(h):cyclinB1(h)--> Cdc25A(h){pS115}{pS320} + 2 ADP (phosphorylation) | Cdc25A(h) + TE2(h) <==> Cdc25A(h):TE2(h) (binding) | Cdc25A(h) + ATP --Chk1(h)--> Cdc25A(h){pS76} + ADP (phosphorylation) | Cdc25A(h) + n ubiquitin(h) --beta-TrCP(m)--> Cdc25A(h){ub(n)} (ubiquitination) | cdc25A(h) --> Cdc25A(h) (expression). | TGFbeta1(h) --/ Cdc25A(h) (decrease of abundance) | Cdc25A(h){pS115}{pS320} --Cdc14A(h)--> Cdc25A(h) + 2 p (dephosphorylation) | Chk1(h) --/ Cdc25A(h) (inhibition; decrease of abundance) | p53(h) --/ Cdc25A(h) (inhibition; decrease of abundance) | ATF-3(h) --/ Cdc25A(h) (inhibition) | IFNalpha(h) --/ Cdc25A(h) (decrease of abundance) | cdc25A(h) --> Cdc25A1(h) (expression). | cdc25A(h) --> Cdc25A2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
76 | Phosphoserine (by CHK1). | Swiss-Prot 53.0 | 124 | Phosphoserine (by CHK1 and CHK2). | Swiss-Prot 53.0 | 178 | Phosphoserine (by CHK1). | Swiss-Prot 53.0 | 279 | Phosphoserine (by CHK1 and CHK2). | Swiss-Prot 53.0 | 293 | Phosphoserine (by CHK1 and CHK2). | Swiss-Prot 53.0 | 507 | Phosphothreonine (by CHK1). | Swiss-Prot 53.0 | 18 | Phosphoserine (CDK1) | 12411508 | Phospho.ELM 6.0 | 76 | Phosphoserine (CHK1) | 12110582;14681206;12759351 | Phospho.ELM 6.0 | 124 | Phosphoserine (CHK2;CHK1) | 12399544;12676583;12759351;11298456 | Phospho.ELM 6.0 | 116 | Phosphoserine (CDK1;Pim-1) | 12411508 | Phospho.ELM 6.0 | 178 | Phosphoserine (CHK2;CHK1) | 12676583 | Phospho.ELM 6.0 | 279 | Phosphoserine (CHK2;CHK1) | 12676583 | Phospho.ELM 6.0 | 293 | Phosphoserine (CHK2;CHK1) | 12676583 | Phospho.ELM 6.0 | 507 | Phosphothreonine (CHK1) | 14559997 | Phospho.ELM 6.0 | 88 | Phosphoserine | 14603323 | Phospho.ELM 6.0 | 82 | Phosphoserine | 14681206 | Phospho.ELM 6.0 | 79 | Phosphoserine | 14681206 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr3 |
Promoter: 48204305 - 48206305 | Agilent_014791 |
chr3 |
Promoter: 48204305 - 48206305 | GSE27584 |
chr3 |
Promoter: 48204305 - 48206305 | GSE27584 |
chr3 |
Promoter: 48204305 - 48206305 | Agilent_014791_44K |
chr3 |
Promoter: 48204305 - 48206305 | Agilent_014791_44K |