| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3127 |
Name | HLA-DRB5 |
Synonymous | HLA-DRB;major histocompatibility complex, class II, DR beta 5;HLA-DRB5;major histocompatibility complex, class II, DR beta 5 |
Definition | DR beta-5|DR-9|DR2-beta-2|DR9|HLA class II histocompatibility antigen, DR beta 5 chain|HLA class II histocompatibility antigen, DR-5 beta chain|HLA class II histocompatibility antigen, DRB1-9 beta chain|MHC HLA-DR-beta cell surface glycoprotein|MHC HLA-DR |
Position | 6p21.3 |
Gene Type | protein-coding |
Gene Mutation: | GWAS results PAH samples Lung cancer |
GWAS results [Top] | ||
|
Variant (Location; Chr; Position; SNP; Allele; Homogeneity) |
Discovery Cohort (Cochran-Armitage Trend Test P-value; P-value from Eigenstrat; MAF cases; MAF controls) |
Replication Cohort (Cochran-Armitage Trend Test P-value; MAF cases; MAF controls) |
|---|---|---|
flanking_3UTR; chr6;32557389;rs1964995;T/C; + - |
7.5839e10-3; 4.4696e10-4; 0.4338; 0.3772 | 0.151; 0.3961; 0.4354 |
Lung cancer [Top] | ||
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
p.E157K; chr6:32487330-32487330 |
lung | squamous_cell_carcinoma; carcinoma |
p.L4L; chr6:32497990-32497990 |
lung | squamous_cell_carcinoma; carcinoma |
p.A13fs*3; chr6:32497965-32497965 |
lung | adenocarcinoma; carcinoma |
p.D31N; chr6:32497911-32497911 |
lung | squamous_cell_carcinoma; carcinoma |