| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 846 |
Name | CASR |
Synonymous | CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|NSHPT|PCAR1;calcium-sensing receptor;CASR;calcium-sensing receptor |
Definition | extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor |
Position | 3q13 |
Gene Type | protein-coding |
Gene Mutation: | GWAS results PAH samples Lung cancer |
GWAS results [Top] | ||
|
Variant (Location; Chr; Position; SNP; Allele; Homogeneity) |
Discovery Cohort (Cochran-Armitage Trend Test P-value; P-value from Eigenstrat; MAF cases; MAF controls) |
Replication Cohort (Cochran-Armitage Trend Test P-value; MAF cases; MAF controls) |
|---|---|---|
intron; chr3;123397547;rs6802749;G/A; + + |
5.4375e10-4; 2.7651e10-4; 0.2074; 0.151 | 0.7801; 0.1655; 0.1601 |
intron; chr3;123416851;rs4678126;A/G; + - |
3.0154e10-4; 1.8122e10-4; 0.2044; 0.1462 | 0.9041; 0.1614; 0.1637 |
Lung cancer [Top] | ||
|
Mutation (Type; AA; Chr) |
Site |
Histology |
|---|---|---|
p.R898Q; chr3:122003494-122003494 |
lung | adenocarcinoma; carcinoma |
p.G549W; chr3:122000996-122000996 |
lung | squamous_cell_carcinoma; carcinoma |
p.D23N; chr3:121973103-121973103 |
lung | squamous_cell_carcinoma; carcinoma |
p.P163S; chr3:121976229-121976229 |
lung | squamous_cell_carcinoma; carcinoma |
p.R873C; chr3:122003418-122003418 |
lung | small_cell_carcinoma; carcinoma |
p.G509G; chr3:121994808-121994808 |
lung | small_cell_carcinoma; carcinoma |
p.E602D; chr3:122002607-122002607 |
lung | adenocarcinoma; carcinoma |
p.E399D; chr3:121981079-121981079 |
lung | adenocarcinoma; carcinoma |
p.A579T; chr3:122002536-122002536 |
lung | adenocarcinoma; carcinoma |
p.N700K; chr3:122002901-122002901 |
lung | adenocarcinoma; carcinoma |
p.I603T; chr3:122002609-122002609 |
lung | squamous_cell_carcinoma; carcinoma |
p.E558*; chr3:122001023-122001023 |
lung | adenocarcinoma; carcinoma |
p.A194V; chr3:121980463-121980463 |
lung | adenocarcinoma; carcinoma |
p.?; chr3:121994653-121994653 |
lung | adenocarcinoma; carcinoma |
p.?; chr3:121981263-121981263 |
lung | adenocarcinoma; carcinoma |
p.N700K; chr3:122002901-122002901 |
lung | adenocarcinoma; carcinoma |
p.I33I; chr3:121973135-121973135 |
lung | adenocarcinoma; carcinoma |
p.S171G; chr3:121980393-121980393 |
lung | squamous_cell_carcinoma; carcinoma |
p.A295S; chr3:121980765-121980765 |
lung | adenocarcinoma; carcinoma |
p.I614I; chr3:122002643-122002643 |
lung | adenocarcinoma; carcinoma |
p.R891P; chr3:122003473-122003473 |
lung | squamous_cell_carcinoma; carcinoma |
p.R890R; chr3:122003471-122003471 |
lung | squamous_cell_carcinoma; carcinoma |
p.D980H; chr3:122003739-122003739 |
lung | squamous_cell_carcinoma; carcinoma |
p.R441fs*21; chr3:121981200-121981200 |
lung | adenocarcinoma; carcinoma |
p.P89P; chr3:121976009-121976009 |
lung | adenocarcinoma; carcinoma |
p.S244S; chr3:121980614-121980614 |
lung | adenocarcinoma; carcinoma |
p.L730L; chr3:122002991-122002991 |
lung | adenocarcinoma; carcinoma |
p.L730L; chr3:122002991-122002991 |
lung | adenocarcinoma; carcinoma |
p.R69H; chr3:121975948-121975948 |
lung | squamous_cell_carcinoma; carcinoma |
p.G363C; chr3:121980969-121980969 |
lung | adenocarcinoma; carcinoma |
p.L87I; chr3:121976001-121976001 |
lung | adenocarcinoma; carcinoma |
p.Q1017L; chr3:122003851-122003851 |
lung | adenocarcinoma; carcinoma |
p.L443I; chr3:121981209-121981209 |
lung | adenocarcinoma; carcinoma |
p.L902V; chr3:122003505-122003505 |
lung | squamous_cell_carcinoma; carcinoma |
p.N1077D; chr3:122004030-122004030 |
lung | adenocarcinoma; carcinoma |
p.L1032R; chr3:122003896-122003896 |
lung | adenocarcinoma; carcinoma |
p.T406>?; chr3:121981100-121981101 |
lung | adenocarcinoma; carcinoma |
p.A772A; chr3:122003117-122003117 |
lung | adenocarcinoma; carcinoma |
p.G613W; chr3:122002638-122002638 |
lung | squamous_cell_carcinoma; carcinoma |
p.A887V; chr3:122003461-122003461 |
lung | small_cell_carcinoma; carcinoma |
p.E870E; chr3:122003411-122003411 |
lung | adenocarcinoma; carcinoma |
p.V1056M; chr3:122003967-122003967 |
lung | adenocarcinoma; carcinoma |
p.A321T; chr3:121980843-121980843 |
lung | adenocarcinoma; carcinoma |
p.T92M; chr3:121976017-121976017 |
lung | adenocarcinoma; carcinoma |
p.L770I; chr3:122003109-122003109 |
lung | adenocarcinoma; carcinoma |
p.L770I; chr3:122003109-122003109 |
lung | adenocarcinoma; carcinoma |
p.R340S; chr3:121980902-121980902 |
lung | adenocarcinoma; carcinoma |
p.R891L; chr3:122003473-122003473 |
lung | adenocarcinoma; carcinoma |
p.F183Y; chr3:121980430-121980430 |
lung | squamous_cell_carcinoma; carcinoma |
p.S247Y; chr3:121980622-121980622 |
lung | adenocarcinoma; carcinoma |
p.S1061N; chr3:122003983-122003983 |
lung | adenocarcinoma; carcinoma |
p.A887G; chr3:122003461-122003461 |
lung | adenocarcinoma; carcinoma |
p.D199H; chr3:121980477-121980477 |
lung | small_cell_carcinoma; carcinoma |
p.T1026T; chr3:122003879-122003879 |
lung | adenocarcinoma; carcinoma |
p.L696L; chr3:122002887-122002887 |
lung | adenocarcinoma; carcinoma |
p.N176N; chr3:121980410-121980410 |
lung | squamous_cell_carcinoma; carcinoma |
p.R961K; chr3:122003683-122003683 |
lung | adenocarcinoma; carcinoma |
p.R227Q; chr3:121980562-121980562 |
lung | adenocarcinoma; carcinoma |
p.R891G; chr3:122003472-122003472 |
lung | squamous_cell_carcinoma; carcinoma |
p.R898R; chr3:122003495-122003495 |
lung | squamous_cell_carcinoma; carcinoma |
p.E350V; chr3:121980931-121980931 |
lung | squamous_cell_carcinoma; carcinoma |