Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1027

Name

CDKN1B

Synonymous

CDKN4|KIP1|MEN1B|MEN4|P27KIP1;cyclin-dependent kinase inhibitor 1B (p27, Kip1);CDKN1B;cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Definition

cyclin-dependent kinase inhibitor 1B

Position

12p13.1-p12

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for CDKN1B

Transcription Factors   [Top]

Regulation From TransFac database

cyclinE(h):Cdk2(h) + p27Kip1(h) <==> cyclinE(h):Cdk2(h):p27Kip1(h) (binding)
cyclinA(h):Cdk2(h) + p27Kip1(h) <==> cyclinA(h):Cdk2(h):p27Kip1(h) (binding)
Cdk4(h) + p27Kip1(h) <==> Cdk4(h):p27Kip1(h) (binding)
Cdk6(h) + p27Kip1(h) <==> Cdk6(h):p27Kip1(h) (binding)
cyclinE(h) + p27Kip1(h) <==> cyclinE(h):p27Kip1(h) (binding)
E2F-4(h):DP-1(h):p107(h):cyclinA(h):Cdk2(h) + p27Kip1(h) <==> E2F-4(h):DP-1(h):p107(h) + cyclinA(h):Cdk2(h):p27Kip1(h) (binding; dissociation)
AKT-1(h){pT308} + p27Kip1(h) <==> AKT-1(h){pT308}:p27Kip1(h) (binding)
AKT(h){pS473} + p27Kip1(h) <==> AKT(h){pS473}:p27Kip1(h) (binding)
p27Kip1(h) + 2 ATP --AKT-1(h){pT308}{pS473}--> p27Kip1(h){pT157}{pT198} + 2 ADP (phosphorylation)
JAB1(h) + p27Kip1(h) <==> JAB1(h):p27Kip1(h) (binding)
p27Kip1(h) + Skp2(h) <==> p27Kip1(h):Skp2(h) (binding)
cyclinE1(h) + p27Kip1(h) <==> cyclinE1(h):p27Kip1(h) (binding)
Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding)
p27Kip1(h) + cyclinD1(h) + Cdk4(h) <==> p27Kip1(h):cyclinD1(h):Cdk4(h) (binding)
cyclinD1(h) + p27Kip1(h) <==> cyclinD1(h):p27Kip1(h) (binding)
Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding)
p27Kip1(h) --> protein remnants (degradation)
p27Kip1(h) + CUL4A(m.s.) <==> p27Kip1(h):CUL4A(m.s.) (binding)
p27Kip1(h) --> p27Kip1(h) (translocation)
p27Kip1(h) + cyclinD2(h) <==> p27Kip1(h):cyclinD2(h) (binding)
cyclinD3(h) + p27Kip1(h) <==> cyclinD3(h):p27Kip1(h) (binding)
p27Kip1(h) + TRAF2(h) <==> p27Kip1(h):TRAF2(h) (binding)
p27Kip1(h) + Pim(h) <==> p27Kip1(h):Pim(h) (binding)
p27Kip1(h) + pim1(h) <==> p27Kip1(h):pim1(h) (binding)
p27Kip1(h) + ATP --pim1(h)--> p27Kip1(h){p} + ADP (phosphorylation)
p27Kip1(h) + cyclinA(h) <==> p27Kip1(h):cyclinA(h) (binding)
p27Kip1(h) + ubiquitin(h) --> p27Kip1(h){ub} (ubiquitination)
Hsc70(h) + p27Kip1(h) <==> Hsc70(h):p27Kip1(h) (binding)
Histatin-3(h) + Hsc70-isoform1(h) + p27Kip1(h) <==> Histatin-3(h):Hsc70-isoform1(h):p27Kip1(h) (binding)
CDKN1B(h) --> p27Kip1(h) (expression).
E47(h) --> p27Kip1(h) (increase of abundance)
SIRT1(m) --> p27Kip1(h) (increase of abundance)
15d-PGJ2 --/ p27Kip1(h) (decrease of abundance)
DDB1(h) --/ p27Kip1(h) (decrease of abundance)
COPS1(h) --/ p27Kip1(h) (decrease of abundance)
DDB1(h) --> p27Kip1(h) (decrease of transport)
DDB1(m.s.) --/ p27Kip1(h) (decrease of abundance)
Skp2(h) --/ p27Kip1(h) (decrease of abundance)
ERK(h) --/ p27Kip1(h) (decrease of abundance)
FOXO3a(m.s.) --> p27Kip1(h) (increase of abundance)
p27Kip1(h) --> p27Kip1(h) (translocation)
TGFbeta1(h) --> p27Kip1(h) (increase of abundance)
Cdx-2(h) --/ p27Kip1(h) (decrease of abundance)
s100a11(h) --/ p27Kip1(h) (decrease of abundance)
Skp2(m.s.) --/ p27Kip1(h) (decrease of abundance)
EGF(m.s.) --/ p27Kip1(h) (decrease of abundance)
AKT-1(h) --/ p27Kip1(h) (decrease of abundance)
Fzr(h) --> p27Kip1(h) (increase of abundance)
p27Kip1(h) + Cdk4(h) <==> p27Kip1(h):Cdk4(h) (binding)
p27Kip1(h) + cyclinE(h) + Cdk2(h) <==> p27Kip1(h):cyclinE(h):Cdk2(h) (binding)
p27Kip1(h) + cyclinD1(h) <==> p27Kip1(h):cyclinD1(h) (binding)
p27Kip1(h) + 2 ATP --pim1(h)--> p27Kip1(h){pT157}{pT198} + 2 ADP (phosphorylation)
p27Kip1(h) + 14-3-3(h) <==> p27Kip1(h):14-3-3(h) (binding)
p27Kip1(h) + 14-3-3beta(h) <==> p27Kip1(h):14-3-3beta(h) (binding)
p27Kip1(h) + 14-3-3eta(h) <==> p27Kip1(h):14-3-3eta(h) (binding)
p27Kip1(h) + 14-3-3sigma(h) <==> p27Kip1(h):14-3-3sigma(h) (binding)
p27Kip1(h) + 14-3-3zeta(h) <==> p27Kip1(h):14-3-3zeta(h) (binding)
p27Kip1(h) + 14-3-3gamma(h) <==> p27Kip1(h):14-3-3gamma(h) (binding)
p27Kip1(h) + 14-3-3tau(h) <==> p27Kip1(h):14-3-3tau(h) (binding)
p27Kip1(h) + n ubiquitin(h) --ATP,KPC1-isoform1(h),Ubc5A(h),E1(h)--> p27Kip1(h){ub(n)} (ubiquitination)
CDKN1B(h) --> p27Kip1(h) (expression).
p27Kip1(h){p} --Cdc14A(h)--> p27Kip1(h) + p (dephosphorylation)
pim1(h) --/ p27Kip1(h) (decrease of abundance)
CDKN1B(h) --> CDKN1B(h) (expression).
hsa-miR-221 --/ CDKN1B(h) (increase of mRNA decay).
hsa-miR-222 --/ CDKN1B(h) (increase of mRNA decay).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

10Phosphoserine (by UHMK1).Swiss-Prot 53.0
10Phosphoserine (KIS;CDK2)15302935;12093740;12042314;15735731;14504289;12482Phospho.ELM 6.0
187Phosphothreonine (MAPK1;CDK2)10831586;12700233;12042314;15735731Phospho.ELM 6.0
178Phosphoserine (MAPK1)10831586Phospho.ELM 6.0
83Phosphoserine (CK2 alpha)15034923Phospho.ELM 6.0
89Phosphotyrosine16195327Phospho.ELM 6.0
88Phosphotyrosine16195327Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr12

Promoter: 12760076 - 12762076Agilent_014791

chr12

Promoter: 12760076 - 12762076GoldenGate_Methylation_Cancer_Panel_I

chr12

Promoter: 12760076 - 12762076GSE27584

chr12

Promoter: 12760076 - 12762076PMID:12149142

chr12

Promoter: 12760076 - 12762076PMID:11943705

chr12

Promoter: 12760076 - 12762076PMID:11042700

chr12

Promoter: 12760076 - 12762076PMID:11522621

chr12

Promoter: 12760076 - 12762076PMID:15975525

chr12

Promoter: 12760076 - 12762076PMID:15695118


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