| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 1027 |
Name | CDKN1B |
Synonymous | CDKN4|KIP1|MEN1B|MEN4|P27KIP1;cyclin-dependent kinase inhibitor 1B (p27, Kip1);CDKN1B;cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
Definition | cyclin-dependent kinase inhibitor 1B |
Position | 12p13.1-p12 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for CDKN1B | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
cyclinE(h):Cdk2(h) + p27Kip1(h) <==> cyclinE(h):Cdk2(h):p27Kip1(h) (binding) | cyclinA(h):Cdk2(h) + p27Kip1(h) <==> cyclinA(h):Cdk2(h):p27Kip1(h) (binding) | Cdk4(h) + p27Kip1(h) <==> Cdk4(h):p27Kip1(h) (binding) | Cdk6(h) + p27Kip1(h) <==> Cdk6(h):p27Kip1(h) (binding) | cyclinE(h) + p27Kip1(h) <==> cyclinE(h):p27Kip1(h) (binding) | E2F-4(h):DP-1(h):p107(h):cyclinA(h):Cdk2(h) + p27Kip1(h) <==> E2F-4(h):DP-1(h):p107(h) + cyclinA(h):Cdk2(h):p27Kip1(h) (binding; dissociation) | AKT-1(h){pT308} + p27Kip1(h) <==> AKT-1(h){pT308}:p27Kip1(h) (binding) | AKT(h){pS473} + p27Kip1(h) <==> AKT(h){pS473}:p27Kip1(h) (binding) | p27Kip1(h) + 2 ATP --AKT-1(h){pT308}{pS473}--> p27Kip1(h){pT157}{pT198} + 2 ADP (phosphorylation) | JAB1(h) + p27Kip1(h) <==> JAB1(h):p27Kip1(h) (binding) | p27Kip1(h) + Skp2(h) <==> p27Kip1(h):Skp2(h) (binding) | cyclinE1(h) + p27Kip1(h) <==> cyclinE1(h):p27Kip1(h) (binding) | Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding) | p27Kip1(h) + cyclinD1(h) + Cdk4(h) <==> p27Kip1(h):cyclinD1(h):Cdk4(h) (binding) | cyclinD1(h) + p27Kip1(h) <==> cyclinD1(h):p27Kip1(h) (binding) | Cdk2(h) + p27Kip1(h) <==> Cdk2(h):p27Kip1(h) (binding) | p27Kip1(h) --> protein remnants (degradation) | p27Kip1(h) + CUL4A(m.s.) <==> p27Kip1(h):CUL4A(m.s.) (binding) | p27Kip1(h) --> p27Kip1(h) (translocation) | p27Kip1(h) + cyclinD2(h) <==> p27Kip1(h):cyclinD2(h) (binding) | cyclinD3(h) + p27Kip1(h) <==> cyclinD3(h):p27Kip1(h) (binding) | p27Kip1(h) + TRAF2(h) <==> p27Kip1(h):TRAF2(h) (binding) | p27Kip1(h) + Pim(h) <==> p27Kip1(h):Pim(h) (binding) | p27Kip1(h) + pim1(h) <==> p27Kip1(h):pim1(h) (binding) | p27Kip1(h) + ATP --pim1(h)--> p27Kip1(h){p} + ADP (phosphorylation) | p27Kip1(h) + cyclinA(h) <==> p27Kip1(h):cyclinA(h) (binding) | p27Kip1(h) + ubiquitin(h) --> p27Kip1(h){ub} (ubiquitination) | Hsc70(h) + p27Kip1(h) <==> Hsc70(h):p27Kip1(h) (binding) | Histatin-3(h) + Hsc70-isoform1(h) + p27Kip1(h) <==> Histatin-3(h):Hsc70-isoform1(h):p27Kip1(h) (binding) | CDKN1B(h) --> p27Kip1(h) (expression). | E47(h) --> p27Kip1(h) (increase of abundance) | SIRT1(m) --> p27Kip1(h) (increase of abundance) | 15d-PGJ2 --/ p27Kip1(h) (decrease of abundance) | DDB1(h) --/ p27Kip1(h) (decrease of abundance) | COPS1(h) --/ p27Kip1(h) (decrease of abundance) | DDB1(h) --> p27Kip1(h) (decrease of transport) | DDB1(m.s.) --/ p27Kip1(h) (decrease of abundance) | Skp2(h) --/ p27Kip1(h) (decrease of abundance) | ERK(h) --/ p27Kip1(h) (decrease of abundance) | FOXO3a(m.s.) --> p27Kip1(h) (increase of abundance) | p27Kip1(h) --> p27Kip1(h) (translocation) | TGFbeta1(h) --> p27Kip1(h) (increase of abundance) | Cdx-2(h) --/ p27Kip1(h) (decrease of abundance) | s100a11(h) --/ p27Kip1(h) (decrease of abundance) | Skp2(m.s.) --/ p27Kip1(h) (decrease of abundance) | EGF(m.s.) --/ p27Kip1(h) (decrease of abundance) | AKT-1(h) --/ p27Kip1(h) (decrease of abundance) | Fzr(h) --> p27Kip1(h) (increase of abundance) | p27Kip1(h) + Cdk4(h) <==> p27Kip1(h):Cdk4(h) (binding) | p27Kip1(h) + cyclinE(h) + Cdk2(h) <==> p27Kip1(h):cyclinE(h):Cdk2(h) (binding) | p27Kip1(h) + cyclinD1(h) <==> p27Kip1(h):cyclinD1(h) (binding) | p27Kip1(h) + 2 ATP --pim1(h)--> p27Kip1(h){pT157}{pT198} + 2 ADP (phosphorylation) | p27Kip1(h) + 14-3-3(h) <==> p27Kip1(h):14-3-3(h) (binding) | p27Kip1(h) + 14-3-3beta(h) <==> p27Kip1(h):14-3-3beta(h) (binding) | p27Kip1(h) + 14-3-3eta(h) <==> p27Kip1(h):14-3-3eta(h) (binding) | p27Kip1(h) + 14-3-3sigma(h) <==> p27Kip1(h):14-3-3sigma(h) (binding) | p27Kip1(h) + 14-3-3zeta(h) <==> p27Kip1(h):14-3-3zeta(h) (binding) | p27Kip1(h) + 14-3-3gamma(h) <==> p27Kip1(h):14-3-3gamma(h) (binding) | p27Kip1(h) + 14-3-3tau(h) <==> p27Kip1(h):14-3-3tau(h) (binding) | p27Kip1(h) + n ubiquitin(h) --ATP,KPC1-isoform1(h),Ubc5A(h),E1(h)--> p27Kip1(h){ub(n)} (ubiquitination) | CDKN1B(h) --> p27Kip1(h) (expression). | p27Kip1(h){p} --Cdc14A(h)--> p27Kip1(h) + p (dephosphorylation) | pim1(h) --/ p27Kip1(h) (decrease of abundance) | CDKN1B(h) --> CDKN1B(h) (expression). | hsa-miR-221 --/ CDKN1B(h) (increase of mRNA decay). | hsa-miR-222 --/ CDKN1B(h) (increase of mRNA decay). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
10 | Phosphoserine (by UHMK1). | Swiss-Prot 53.0 | 10 | Phosphoserine (KIS;CDK2) | 15302935;12093740;12042314;15735731;14504289;12482 | Phospho.ELM 6.0 | 187 | Phosphothreonine (MAPK1;CDK2) | 10831586;12700233;12042314;15735731 | Phospho.ELM 6.0 | 178 | Phosphoserine (MAPK1) | 10831586 | Phospho.ELM 6.0 | 83 | Phosphoserine (CK2 alpha) | 15034923 | Phospho.ELM 6.0 | 89 | Phosphotyrosine | 16195327 | Phospho.ELM 6.0 | 88 | Phosphotyrosine | 16195327 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr12 |
Promoter: 12760076 - 12762076 | Agilent_014791 |
chr12 |
Promoter: 12760076 - 12762076 | GoldenGate_Methylation_Cancer_Panel_I |
chr12 |
Promoter: 12760076 - 12762076 | GSE27584 |
chr12 |
Promoter: 12760076 - 12762076 | PMID:12149142 |
chr12 |
Promoter: 12760076 - 12762076 | PMID:11943705 |
chr12 |
Promoter: 12760076 - 12762076 | PMID:11042700 |
chr12 |
Promoter: 12760076 - 12762076 | PMID:11522621 |
chr12 |
Promoter: 12760076 - 12762076 | PMID:15975525 |
chr12 |
Promoter: 12760076 - 12762076 | PMID:15695118 |