| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1072 |
Name | CFL1 |
Synonymous | CFL;cofilin 1 (non-muscle);CFL1;cofilin 1 (non-muscle) |
Definition | 18 kDa phosphoprotein|cofilin, non-muscle isoform|cofilin-1|p18 |
Position | 11q13 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr11:65590493-65629497 | chr11:65624025-65624025 | rs665306 | Single_Nucleotides|eQTL|EFEMP2, Motifs|PWM|NF-E2, Motifs|Footprinting|AP-1, Motifs|PWM|AP-1, Motifs|PWM|AP-1, Motifs|PWM|AP-1, Motifs|PWM|AP-1, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Monocd14, Protein_Binding|ChIP-seq|CREBBP, Protein_Binding|ChIP-seq|ELF1, Protein_Binding|ChIP-seq|POLR2A |
|---|---|---|---|
Transcription Factors [Top] |
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Regulation From TransFac database |
cofilin-1(h) + ATP --LIMK1-isoform1(h)--> cofilin-1(h){pS3} + ADP (phosphorylation) | CFL1(h) --> cofilin-1(h) (expression). | cofilin-1(h) + SM22(h) <==> cofilin-1(h):SM22(h) (binding) | beta-actin(h) + cofilin-1(h) <==> beta-actin(h):cofilin-1(h) (binding) | gamma-actin(h) + cofilin-1(h) <==> gamma-actin(h):cofilin-1(h) (binding) | cofilin-1(h) + ATP --> cofilin-1(h){pS3} + ADP (phosphorylation) | CFL1(h) --> cofilin-1(h) (expression). | cofilin-1(h){pS3} --SSH1L(h)--> cofilin-1(h) + p (dephosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-acetylalanine. | Swiss-Prot 53.0 | 3 | Phosphoserine (by NRK). | Swiss-Prot 53.0 | 25 | Phosphothreonine. | Swiss-Prot 53.0 | 132 | N6-acetyllysine. | Swiss-Prot 53.0 | 140 | Phosphotyrosine. | Swiss-Prot 53.0 | 156 | Phosphoserine. | Swiss-Prot 53.0 | 139 | Phosphotyrosine | 15592455 | Phospho.ELM 6.0 | 2 | Phosphoserine (LIMK1;LIMK2;) | 9655398;11418599;11340065 | Phospho.ELM 6.0 | 24 | Phosphothreonine | 17081983 | Phospho.ELM 6.0 | 67 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 65381880 - 65383880 | GSE27584 |
chr11 |
Promoter: 65381880 - 65383880 | Agilent_014791_44K |
chr11 |
Promoter: 65381880 - 65383880 | Agilent_014791 |