| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 1906 |
Name | EDN1 |
Synonymous | ET1|HDLCQ7|PPET1;endothelin 1;EDN1;endothelin 1 |
Definition | endothelin-1|preproendothelin-1 |
Position | 6p24.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for EDN1 | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
EDN1(h) --> ET-1(h) (expression). | p53(h) --> ET-1(h) (increase of secretion) | ET-1(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | ET-1(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | EDN1(h) --> ET-1(h) (expression). | EDN1(h) --> endothelin-1 isoform 2 preproprotein(h) (expression). | hsa-miR-155 --/ endothelin-1 isoform 2 preproprotein(h) (increase of mRNA decay). | hsa-miR-199 --/ endothelin-1 isoform 2 preproprotein(h) (increase of mRNA decay). | rno-miR-155 --/ endothelin-1 isoform 2 preproprotein(h) (increase of mRNA decay). | rno-miR-199 --/ endothelin-1 isoform 2 preproprotein(h) (increase of mRNA decay). | hsa-miR-135 --/ endothelin-1 isoform 2 preproprotein(h) (increase of mRNA decay). | rno-miR-135 --/ endothelin-1 isoform 2 preproprotein(h) (increase of mRNA decay). | EDN1(h) --> endothelin-1 isoform 1 preproprotein(h) (expression). | hsa-miR-155 --/ endothelin-1 isoform 1 preproprotein(h) (increase of mRNA decay). | hsa-miR-199 --/ endothelin-1 isoform 1 preproprotein(h) (increase of mRNA decay). | rno-miR-155 --/ endothelin-1 isoform 1 preproprotein(h) (increase of mRNA decay). | rno-miR-199 --/ endothelin-1 isoform 1 preproprotein(h) (increase of mRNA decay). | hsa-miR-135 --/ endothelin-1 isoform 1 preproprotein(h) (increase of mRNA decay). | rno-miR-135 --/ endothelin-1 isoform 1 preproprotein(h) (increase of mRNA decay). |
|---|
Post Transcriptional Modification [Top] | |||
There is no record for EDN1 | |||
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr6 |
Promoter: 12397145 - 12399145 | GoldenGate_Methylation_Cancer_Panel_I |
chr6 |
Promoter: 12397145 - 12399145 | GSE27584 |
chr6 |
Promoter: 12397145 - 12399145 | PMID:11709722 |