| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2150 |
Name | F2RL1 |
Synonymous | GPR11|PAR2;coagulation factor II (thrombin) receptor-like 1;F2RL1;coagulation factor II (thrombin) receptor-like 1 |
Definition | G-protein coupled receptor 11|coagulation factor II receptor-like 1|protease-activated receptor 2|proteinase-activated receptor 2|thrombin receptor-like 1 |
Position | 5q13 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr5:76114758-76131140 | chr5:76117117-76117117 | rs2243004 | Single_Nucleotides|eQTL|F2RL1, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|Hct116 | chr5:76114758-76131140 | chr5:76127135-76127135 | rs2243057 | Single_Nucleotides|eQTL|F2RL1, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|FAIRE|Astrocy, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Panc1, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|FAIRE|Htr8, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Panislets, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|FAIRE|Gm12878, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Hmveclly, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|FAIRE|H1hesc, Chromatin_Structure|FAIRE|Mcf7, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|FAIRE|Gm18507, Chromatin_Structure|FAIRE|Nhek, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|FAIRE|Gm12892, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|BATF, Protein_Binding|ChIP-seq|BCL11A, Protein_Binding|ChIP-seq|BCL3, Protein_Binding|ChIP-seq|SP1, Protein_Binding|ChIP-seq|BCL3, Protein_Binding|ChIP-seq|NFKB1, Protein_Binding|ChIP-seq|NFKB1 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
PAR2(h) + ubiquitin(r) --> PAR2(h){ub} (ubiquitination) | PAR2(h) + ubiquitin(h) --> PAR2(h){ub} (ubiquitination) | PAR2(h) + c-Cbl(r) <==> PAR2(h):c-Cbl(r) (binding) | PAR2(h) --> Cdc42(h) (activation) | PAR2(h) --> IL-8(h) (increase of abundance) | F2RL1(h) --> PAR2(h) (expression). | Dkk-1(h) --/ PAR2(h) (decrease of abundance) | PAR2(h) --> PGE2 (increase of secretion) | PAR2(h) --> prostaglandin F2-alpha (increase of secretion) | F2RL1(h) --> PAR2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
30 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 222 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr5 |
Promoter: 76149110 - 76151110 | Agilent_014791 |
chr5 |
Promoter: 76149110 - 76151110 | GSE27584 |
chr5 |
Promoter: 76149110 - 76151110 | Agilent_014791_44K |