| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2353 |
Name | FOS |
Synonymous | AP-1|C-FOS|p55;FBJ murine osteosarcoma viral oncogene homolog;FOS;FBJ murine osteosarcoma viral oncogene homolog |
Definition | FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos |
Position | 14q24.3 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for FOS | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
c-Fos(h) --> BZLF1(EBV) (DNA binding). | c-Fos(h) --> MMP1(h) (DNA binding). | c-Fos(h) --> MT2A(h) (DNA binding). | c-Fos(h) --> ENK(h) (DNA binding). | c-Fos(h) --> PLF(m) (DNA binding). | c-Fos(h) --> HBB(h) (DNA binding). | c-Fos(h) --> MMTV(MMTV) (DNA binding). | c-Fos(h) --> HLA-DRA(h) (DNA binding). | c-Fos(h) --> HLA-DPB(h) (DNA binding). | c-Fos(h) --> junD(m) (DNA binding). | c-Fos(h) --> IL2(h) (DNA binding). | c-Fos(h) --> EDN1(h) (DNA binding). | c-Fos(h) --> uPA(h) (DNA binding). | c-Fos(h) --> TP53(h) (DNA binding). | ATF(h) + c-Fos(h) <==> ATF(h):c-Fos(h) (binding). | c-Fos(h) + c-Jun(c) <==> c-Fos(h):c-Jun(c) (binding). | c-Fos(h) + c-Jun(m) <==> c-Fos(h):c-Jun(m) (binding). | c-Fos(h) + c-Jun(r) <==> c-Fos(h):c-Jun(r) (binding). | c-Fos(h) + JunD(m) <==> c-Fos(h):JunD(m) (binding). | c-Fos(h) + RelA-p65(h) <==> c-Fos(h):RelA-p65(h) (binding). | C/EBPbeta(h) + c-Fos(h) <==> C/EBPbeta(h):c-Fos(h) (binding). | c-Fos(h) + c-Jun(h) <==> c-Fos(h):c-Jun(h) (binding). | c-Fos(h) + ATF-2-xbb4(h) <==> c-Fos(h):ATF-2-xbb4(h) (binding). | c-Fos(h) + GR-alpha(h) <==> c-Fos(h):GR-alpha(h) (binding). | c-Jun(HA) + c-Fos(h) <==> c-Jun(HA):c-Fos(h) (binding). | c-Fos(h) + JunB(m) <==> c-Fos(h):JunB(m) (binding). | c-Fos(h) + USF2(h) <==> c-Fos(h):USF2(h) (binding). | E1A 12S protein(AD) + c-Fos(h) <==> E1A 12S protein(AD):c-Fos(h) (binding). | GR-beta(h) + c-Fos(h) <==> GR-beta(h):c-Fos(h) (binding). | USF2(r) + c-Fos(h) <==> USF2(r):c-Fos(h) (binding). | c-Fos(h) + Ref-1(h) <==> c-Fos(h):Ref-1(h) (binding). | c-Fos(h) + p300(h) <==> c-Fos(h):p300(h) (binding) | c-Fos(h) + XBP-1(h) <==> c-Fos(h):XBP-1(h) (binding). | c-Fos(h) + v-Jun(ASV17) <==> c-Fos(h):v-Jun(ASV17) (binding). | c-Fos(h) + ATF-4(h) <==> c-Fos(h):ATF-4(h) (binding). | c-Fos(h) + NRL(h) <==> c-Fos(h):NRL(h) (binding). | c-Fos(h) + E1A 13S protein(AD2) <==> c-Fos(h):E1A 13S protein(AD2) (binding). | c-Fos(h) --> FOSL1(h) (DNA binding; transactivation). | c-Fos(h) --> KRT16(h) (DNA binding). | c-Fos(h) --/ FOS(h) (DNA binding; transrepression). | c-Fos(h) --> WEE1(h) (DNA binding; transactivation). | c-Fos(h) --> NAT1(h) (DNA binding). | Elf-1(h) + c-Fos(h) <==> Elf-1(h):c-Fos(h) (binding) [re. | c-Fos(h) + p38gamma(h) <==> c-Fos(h):p38gamma(h) (binding) | c-Fos(h) --> c-Fos(h) (translocation) | c-Fos(h) --> OPRM1(h) (DNA binding). | c-Fos(h) + sumo1(m.s.) --> c-Fos(h){sumo} (sumoylation) | c-Fos(h) + SUMO2(m.s.) --> c-Fos(h){sumo2} (sumoylation) | c-Fos(h) + sumo3(m.s.) --> c-Fos(h){sumo3} (sumoylation) | c-Fos(h) --> GNRHR(h) (DNA binding; transactivation). | c-Fos(h) --> DBH(h) (DNA binding). | c-Fos(h) --> GNAI2(h) (DNA binding). | c-Fos(h) --> Gast(m) (DNA binding; transactivation). | c-Fos(h) --> CYP19A1(h) (DNA binding). | c-Fos(h) --> CCND1(h) (DNA binding). | c-Fos(h) --> PTGS2(h) (DNA binding). | c-Fos(h) --> MMP2(h) (DNA binding). | c-Fos(h) --> VIM(h) (DNA binding). | c-Fos(h) --> C3AR1(h) (DNA binding; transactivation). | c-Fos(h) --> MUC2(h) (DNA binding). | c-Fos(h) --> CD38(h) (DNA binding). | c-Fos(h) --> FGFBP1(h) (DNA binding). | c-Fos(h) --> CYP2J2(h) (DNA binding). | c-Fos(h) --> MMP13(h) (DNA binding). | c-Fos(h) --> CD44(h) (DNA binding). | c-Fos(h) --> SERPINB9(h) (DNA binding). | c-Fos(h) + ATP --> c-Fos(h){p} + ADP (phosphorylation) | c-Fos(h) --> ICAM1(h) (DNA binding). | c-Fos(h) --> IL11(h) (DNA binding). | c-Fos(h) --/ FOXN1(h) (transrepression) | c-Fos(h) --> IL-5(h) (DNA binding). | c-Fos(h) --> FAS(h) (DNA binding). | c-Fos(h) --/ NOTCH1(h) (transrepression) | c-Fos(h) --> Agtr1b(r) (DNA binding). | c-Fos(h) --> IBSP(h) (DNA binding). | FOS(h) --> c-Fos(h) (expression). | c-Fos(h) --> c-Fos(h) (translocation) | EWS(h) --> c-Fos(h) (increase of abundance) | estradiol --> c-Fos(h) (increase of abundance) | angiotensin II(h) --> c-Fos(h) (increase of abundance) | IL-17A(h) --> c-Fos(h) (increase of abundance) | GM-CSF(m.s.) --> c-Fos(h) (increase of abundance) | Substance P(m.s.) --> c-Fos(h) (increase of abundance) | c-Fos(h) --> Jun(m) (DNA binding; transregulation). | c-Fos(h) --> Il2(m) (DNA binding). | c-Fos(h) --> Il4(m) (DNA binding). | c-Fos(h) --> IL8(h) (DNA binding; transactivation). | c-Fos(h) + c-Jun(m) <==> c-Fos(h):c-Jun(m) (binding) | c-Fos(h) + CHOP-10(h) <==> c-Fos(h):CHOP-10(h) (binding) | ATF-2-xbb4(h) + c-Fos(h) <==> ATF-2-xbb4(h):c-Fos(h) (binding) | ATFa-isoform3(h) + c-Fos(h) <==> ATFa-isoform3(h):c-Fos(h) (binding) | CREBPA-Alpha(h) + c-Fos(h) <==> CREBPA-Alpha(h):c-Fos(h) (binding) | c-Jun(h) + c-Fos(h) <==> c-Jun(h):c-Fos(h) (binding) | JunB(h) + c-Fos(h) <==> JunB(h):c-Fos(h) (binding) | JunD(h) + c-Fos(h) <==> JunD(h):c-Fos(h) (binding) | c-Fos(h) + ATF-4(h) <==> c-Fos(h):ATF-4(h) (binding) | c-Fos(h) + MafB(h) <==> c-Fos(h):MafB(h) (binding) | Fra-2(h) + c-Fos(h) <==> Fra-2(h):c-Fos(h) (binding) | SIRT1(h) + c-Fos(h) <==> SIRT1(h):c-Fos(h) (binding) | c-Fos(h) + acetyl-CoA --p300(m.s.)--> c-Fos(h){ace} + CoA (acetylation) | FOS(h) --> c-Fos(h) (expression). | c-Fos(h){ace} --SIRT1(m.s.)--> c-Fos(h) + acetyl (deacetylation) | c-Fos(m){aceK} --SIRT1(m.s.)--> c-Fos(h) + acetyl (deacetylation) | FOS(h) --> c-Fos(h) (expression). | hsa-miR-101 --/ c-Fos(h) (translational repression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
113 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 232 | Phosphothreonine (MAPK1;MAPK3) | 7816602 | Phospho.ELM 6.0 | 325 | Phosphothreonine (MAP2K2) | 12972619 | Phospho.ELM 6.0 | 331 | Phosphothreonine (MAP2K2) | 12972619 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr14 |
Promoter: 74813784 - 74815784 | Agilent_014791 |
chr14 |
Promoter: 74813784 - 74815784 | GSE27584 |