| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 240 |
Name | ALOX5 |
Synonymous | 5-LO|5-LOX|5LPG|LOG5;arachidonate 5-lipoxygenase;ALOX5;arachidonate 5-lipoxygenase |
Definition | LOX-5|arachidonic 5-lipoxygenase alpha-10 isoform|arachidonic 5-lipoxygenase delta-10-13 isoform|arachidonic 5-lipoxygenase delta-13 isoform|arachidonic 5-lipoxygenase delta-p10 isoform|arachidonic acid 5-lipoxygenase|leukotriene A4 synthase |
Position | 10q11.2 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr10:45869661-45941561 | chr10:45872210-45872210 | rs12783095 | Single_Nucleotides|eQTL|ALOX5, Motifs|Footprinting|Fos, Motifs|PWM|Fos, Motifs|Footprinting|COUPdirectrepeat1, Motifs|PWM|COUPdirectrepeat1, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|Fos, Motifs|Footprinting|Fos, Motifs|Footprinting|Fos, Motifs|Footprinting|COUPdirectrepeat1, Motifs|Footprinting|COUPdirectrepeat1, Motifs|Footprinting|COUPdirectrepeat1, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|COUPdirectrepeat1, Motifs|Footprinting|Fos, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|Footprinting|PPARgamma:RXRalpha=PPARgamma, Motifs|PWM|PPARgamma:RXRalpha=PPARgamma, Motifs|PWM|PPARgamma:RXRalpha=PPARgamma, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|FAIRE|Gm19239, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hct116, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|JUNB, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|JUND | chr10:45869661-45941561 | chr10:45874660-45874660 | rs3780894 | Single_Nucleotides|eQTL|ALOX5, Chromatin_Structure|DNase-seq|Cmk, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Monocd14 | chr10:45869661-45941561 | chr10:45875066-45875066 | rs3780897 | Single_Nucleotides|eQTL|ALOX5, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Caco2 | chr10:45869661-45941561 | chr10:45875409-45875409 | rs17157736 | Single_Nucleotides|eQTL|ALOX5, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Gm12892 | chr10:45869661-45941561 | chr10:45875793-45875793 | rs7077891 | Single_Nucleotides|eQTL|ALOX5, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Gm18507, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|FAIRE|Gm18507, Chromatin_Structure|DNase-seq|Cmk, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|FAIRE|Gm12878, Protein_Binding|ChIP-seq|MYC | chr10:45869661-45941561 | chr10:45875980-45875980 | rs3824613 | Single_Nucleotides|eQTL|ALOX5, Chromatin_Structure|DNase-seq|Gm12892 | chr10:45869661-45941561 | chr10:45876916-45876916 | rs12774369 | Single_Nucleotides|eQTL|ALOX5, Motifs|PWM|Nkx2-5, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Nb4, Protein_Binding|ChIP-seq|SPI1 | chr10:45869661-45941561 | chr10:45877441-45877441 | rs3780898 | Single_Nucleotides|eQTL|ALOX5, Protein_Binding|ChIP-seq|SPI1 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
CLP(h) + arachidonate 5-lipoxygenase(h) <==> CLP(h):arachidonate 5-lipoxygenase(h) (binding) | arachidonate 5-lipoxygenase(h) --Caspase-6(m.s.)--> arachidonate 5-lipoxygenase-p58(h) + protein remnants (cleavage) | ALOX5(h) --> arachidonate 5-lipoxygenase(h) (expression). | arachidonate 5-lipoxygenase(h) + ATP --ERK2(r)--> arachidonate 5-lipoxygenase(h){pS663} + ADP (phosphorylation) | arachidonate 5-lipoxygenase(h) + ATP --ERK1(h)--> arachidonate 5-lipoxygenase(h){p} + ADP (phosphorylation) | arachidonate 5-lipoxygenase(h) + ATP --ERK2(h)--> arachidonate 5-lipoxygenase(h){p} + ADP (phosphorylation) | Grb-2(h) + arachidonate 5-lipoxygenase(h) <==> Grb-2(h):arachidonate 5-lipoxygenase(h) (binding) | arachidonate 5-lipoxygenase(h) + alpha-actinin(c) <==> arachidonate 5-lipoxygenase(h):alpha-actinin(c) (binding) | arachidonate 5-lipoxygenase(h) + actin(rb) <==> arachidonate 5-lipoxygenase(h):actin(rb) (binding) | arachidonate 5-lipoxygenase(h) + myosin(rb) <==> arachidonate 5-lipoxygenase(h):myosin(rb) (binding) | ALOX5(h) --> arachidonate 5-lipoxygenase(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
272 | Phosphoserine (by MAPKAPK2). | Swiss-Prot 53.0 | 524 | Phosphoserine (by PKA). | Swiss-Prot 53.0 | 271 | Phosphoserine (MAPKAPK2;PKA) | 10779545;11844797 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr10 |
Promoter: 45188135 - 45190135 | Agilent_014791 |
chr10 |
Promoter: 45188135 - 45190135 | GSE27584 |
chr10 |
Promoter: 45188135 - 45190135 | Agilent_014791_44K |