| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3082 |
Name | HGF |
Synonymous | DFNB39|F-TCF|HGFB|HPTA|SF;hepatocyte growth factor (hepapoietin A; scatter factor);HGF;hepatocyte growth factor (hepapoietin A; scatter factor) |
Definition | fibroblast-derived tumor cytotoxic factor|hepatocyte growth factor|hepatopoeitin-A|hepatopoietin-A|lung fibroblast-derived mitogen |
Position | 7q21.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr7:81328322-81399754 | chr7:81372156-81372156 | rs5745676 | Single_Nucleotides|eQTL|HGF, Chromatin_Structure|DNase-seq|Be2c |
|---|---|---|---|
Transcription Factors [Top] |
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Regulation From TransFac database |
HGF(h) + c-Met(m) <==> HGF(h):c-Met(m) (binding) | HGF(h) --> FOS(h) (transactivation) | HGF(h) --> ERK1(r){p} (increase of phosphorylation) | HGF(h) --> AKT(r){p} (increase of phosphorylation) | HGF(h) --> p38(r){p} (increase of phosphorylation) | HGF(h) --> TGIF(h) (increase of abundance) | HGF(h) --> TGIF(r) (increase of abundance) | HGF(h) --> ERK2(r){p} (increase of phosphorylation) | HGF(h) --> Sp1(h){pS} (increase of phosphorylation) | HGF(h) --> PKCdelta(h){p} (increase of phosphorylation) | HGF(h) --> VEGF-A(h) (increase of abundance) | HGF(h) --> VEGFA(h) (transactivation) | HGF(h) --> PKCzeta(h){pT410} (increase of phosphorylation) | HGF(h) --> AKT-1(h){pT308}{pS473} (increase of phosphorylation) | HGF(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | HGF(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | HGF(h) --> HGF(h) (expression). | HGF-isoform1(h) --> Gab-1(h):CrkL(h) (increase of binding) | HGF-isoform1(h) --> Gab-1(h):CrkL(h) (increase of binding) | HGF(h) --> HGF-isoform1(h) (expression). | HGF(h) --> HGF-isoform2(h) (expression). | HGF(h) --> HGF-isoform3(h) (expression). | HGF(h) --> HGF-isoform4(h) (expression). | HGF(h) --> HGF-isoform6(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
32 | Pyrrolidone carboxylic acid. | Swiss-Prot 53.0 | 475 | O-linked | Shimizu N., Hara H., Sogabe T., Sakai H., Ihara I., Inoue H.,Nakamura T. and Shimizu S. (1992)Biochem. Biophys. Res. Commun., 189, 1329-1335. Medline: 93129192; | OGlycBase6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 81236888 - 81238888 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 81236888 - 81238888 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 81236888 - 81238888 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 81236888 - 81238888 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 81236888 - 81238888 | GoldenGate_Methylation_Cancer_Panel_I |