Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	3123
Name	HLA-DRB1
Synonymous	DRB1\|DRw10\|HLA-DR1B\|HLA-DRB\|SS1;major histocompatibility complex, class II, DR beta 1;HLA-DRB1;major histocompatibility complex, class II, DR beta 1
Definition	DW2.2/DR2.2\|HLA class II histocompatibility antigen, DR-1 beta chain\|MHC class II HLA-DR beta 1 chain\|MHC class II HLA-DR-beta cell surface glycoprotein\|MHC class II HLA-DRw10-beta\|MHC class II antigen\|human leucocyte antigen DRB1\|lymphocyte antigen DRB1
Position	6p21.3
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr6:32546546-32557625	chr6:32549249-32549249	rs9269794	Single_Nucleotides\|eQTL\|HLA-DRB5, Chromatin_Structure\|FAIRE\|Gm12891, Chromatin_Structure\|DNase-seq\|Werirb1, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A
chr6:32546546-32557625	chr6:32549395-32549395	rs701831	Single_Nucleotides\|eQTL\|HLA-DQA1, Single_Nucleotides\|eQTL\|HLA-DQA1, Motifs\|Footprinting\|, Motifs\|Footprinting\|, Chromatin_Structure\|FAIRE\|Gm12891, Protein_Binding\|ChIP-seq\|PAX5, Protein_Binding\|ChIP-seq\|PAX5, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A, Protein_Binding\|ChIP-seq\|POLR2A

Regulation From TransFac database
Transcription Factors [Top]
HLA-DRB(h) --> HLA-DRB1(h) (expression).

Post Transcriptional Modification [Top]
	There is no record for HLA-DRB1

Chromosome	Location	Source
Methylation Profile [Top]
chr6	Promoter: 32665059 - 32667059	GSE27584
chr6	Promoter: 32665059 - 32667059	PMID:17272309

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