| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3569 |
Name | IL6 |
Synonymous | BSF2|HGF|HSF|IFNB2|IL-6;interleukin 6 (interferon, beta 2);IL6;interleukin 6 (interferon, beta 2) |
Definition | B-cell differentiation factor|B-cell stimulatory factor 2|BSF-2|CDF|CTL differentiation factor|IFN-beta-2|hybridoma growth factor|interferon beta-2|interleukin BSF-2|interleukin-6 |
Position | 7p21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr7:22765503-22771621 | chr7:22768124-22768124 | rs1474347 | Single_Nucleotides|eQTL|NUPL2, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|FAIRE|Gm12891, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Jurkat, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|RAD21, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF |
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Transcription Factors [Top] |
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Regulation From TransFac database |
IL-6(h) + IL-6R(h) <==> IL-6(h):IL-6R(h) (binding) | IL-6(h) --> TLR7(h) (transactivation) | IL-6(h) --> TLR8(h) (transactivation) | IL-6(h) --> STAT3(m){pY705} (increase of phosphorylation) | IL-6(h) --> STAT3(h){pY} (increase of phosphorylation) | IL-6(h) --> STAT3-isoform1(m):gp130(m.s.){pY} (increase of binding) | IL-6(h) --> STAT3-isoform1(m):PKCdelta(m):gp130(m.s.){pY} (increase of binding) | IL-17A(h) --> IL-6(h) (activation) | IL6(h) --> IL-6(h) (expression). | estradiol --/ IL-6(h) (decrease of secretion) | relaxin-2(h) --> IL-6(h) (decrease of secretion) | FcgammaRI alpha(h) --> IL-6(h) (decrease of secretion) | FcgammaRIIA(h) --> IL-6(h) (decrease of secretion) | FCgammaRIIIA(h) --> IL-6(h) (decrease of secretion) | beta-arrestin1(m.s.) --> IL-6(h) (decrease of secretion) | IL-1beta(m.s.) --> IL-6(h) (increase of abundance) | CD154(h) --> IL-6(h) (increase of abundance) | SLAM(h) --/ IL-6(h) (decrease of abundance) | IFNgamma(m.s.) --> IL-6(h) (increase of secretion) | G-CSF(m.s.) --> IL-6(h) (increase of secretion) | IFNgamma(h) --> IL-6(h) (increase of secretion) | IL-17F(h) --> IL-6(h) (increase of secretion) | IL-17A(h):IL-17F(h) --> IL-6(h) (increase of secretion) | IL-17A(h) --> IL-6(h) (increase of secretion) | IL-17A(m.s.) --> IL-6(h) (increase of secretion) | TNF-alpha(m.s.) --> IL-6(h) (increase of secretion) | TRAM(h) --> IL-6(h) (decrease of secretion) | TNF(m.s.) --> IL-6(h) (increase of secretion) | IL-1(m.s.) --> IL-6(h) (increase of abundance) | TNF(m.s.) --> IL-6(h) (increase of abundance) | IL-17A(m.s.) --> IL-6(h) (increase of abundance) | IL-17F(m.s.) --> IL-6(h) (increase of abundance) | H2O2 --> IL-6(h) (increase of secretion) | CpG A --> IL-6(h) (increase of secretion) | 3pRNA --> IL-6(h) (increase of secretion) | IL-1beta(m.s.) --> IL-6(h) (increase of secretion) | TILRR(h) --> IL-6(h) (increase of secretion) | CpG C --> IL-6(h) (increase of secretion) | rnf11(h) --> IL-6(h) (decrease of secretion) | LPS(ECO) --> IL-6(h) (increase of secretion) | LPS --> IL-6(h) (increase of secretion) | IL-6(h) --> STAT3(m):Rac2(m):MgcRacGAP(m) (increase of binding) | IL-6(h) --> MgcRacGAP(h):STAT3(m) (increase of binding) | IL-6(h) --> MgcRacGAP(h):Rac1(m) (increase of binding) | IL-6(h) --> STAT3(h){pY705} (increase of phosphorylation) | IL-6(h) --> STAT3(h){pY} (increase of phosphorylation) | IL-6(h) --> CEBPD(h) (transactivation) | IL-6(h) --> Tbxas1(r) (transactivation) | IL-6(h) --> Cdk9(m.s.):gp130(m.s.) (increase of binding) | IL-6(h) --/ gp130(r) (decrease of abundance) | IL-6(h) --> STAT3(gl){pY705} (increase of phosphorylation) | IL-6(h) --> STAT5(gl){pY} (increase of phosphorylation) | IL-6(h) --> STAT3(r){pY705} (increase of phosphorylation) | IL-6(h) --> STAT3(h){p} (increase of phosphorylation) | IL-6(h) --> C/EBPdelta(h) (increase of abundance) | IL-6(h) --> CRP(h) (increase of secretion) | IL-6(h) --> DEFB4(h) (transactivation) | IL-6(h) --> STAT3(m){pY705} (increase of phosphorylation) | IL-6(h) --> STAT3(h){aceK685} (increase of acetylation) | IL-6(h) --> STAT3(h){pY705}{pS727} (increase of phosphorylation) | IL-6(h) + IL-6R(m.s.) <==> IL-6(h):IL-6R(m.s.) (binding) | IL-6(h) --> STAT3(m){pY} (increase of phosphorylation) | gp130-isoform1(h) + IL-6(h) <==> gp130-isoform1(h):IL-6(h) (binding) | IL-6(h) --> (gp130-isoform1(h))2 (increase of binding) | IL-6(h) --> STAT3(m):STAT3(m) (increase of binding) | IL-6(h) --> Vav(h){pY} (increase of phosphorylation) | IL-6(h) --> Vav(h):gp130-isoform1(h) (increase of binding) | IL-6(h) --> MBP(m.s.){p} (increase of phosphorylation) | IL-6(h) --/ collagen(rb) (decrease of abundance) | IL-6(h) --/ collagen-II(rb) (decrease of abundance) | IL-6(h) --/ COL2A1(rb) (transrepression) | IL-6(h) --/ COL2A1(h) (transrepression) | IL-6(h) --/ SP1(rb) (transrepression) | IL-6(h) --> SP3(rb) (transactivation) | IL-6(h) --/ Sp1(rb) (decrease of abundance) | IL-6(h) --/ Sp3(rb) (decrease of abundance) | IL-6(h) --> SHP-2(r){pY} (increase of phosphorylation) | IL-6(h) --> gp130(r){pY} (increase of phosphorylation) | IL-6(h) --> STAT3(r){pY} (increase of phosphorylation) | IL-6(h) --> ERK1(r){p} (increase of phosphorylation) | IL-6(h) --> ERK2(r){pY} (increase of phosphorylation) | IL-6(h) --> Grb-2(r):SHP-2(r){pY} (increase of binding) | IL-6(h) --> ERK1(h){p} (increase of phosphorylation) | IL-6(h) --> ERK2(h){p} (increase of phosphorylation) | IL-6(h) --> SHP-2(m){pY} (increase of phosphorylation) | IL-6(h) --> Egr1(r) (transactivation) | IL-6(h) --> Fos(r) (transactivation) | IL-6(h) --> Jun(r) (transactivation) | IL-6(h) --> JUNB(r) (transactivation) | IL-6(h) --> Hp(r) (transactivation) | IL-6(h) --> haptoglobin(r) (increase of secretion) | IL-6(h) --> JUNB(h) (transactivation) | IL-6(h) --> ZFP36(h) (transactivation) | IL-6(h) --> STAT3-isoform1(h){pY705}{pS727} (increase of phosphorylation) | IL-6(h) --> JunB(h) (increase of abundance). | IL-6(h) --> histone H3(h){aceK15} (increase of acetylation) | IL-6(h) --> histone H4(h){ace} (increase of acetylation) | IL-6(h) --> Jak1(m.s.){pY} (increase of phosphorylation) | IL6(h) --> IL-6(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
73 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 166 | O-linked | Orita T., Oh-eda M., Hasegawa M., Kuboniwa H., Esaki K. andOchi, N. (1994) J. Biochem., 115, 345-350. Medline: 94266765; | OGlycBase6.0 | 73 | N-liked | Orita T., Oh-eda M., Hasegawa M., Kuboniwa H., Esaki K. andOchi, N. (1994) J. Biochem., 115, 345-350. Medline: 94266765; | OGlycBase6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr7 |
Promoter: 22731845 - 22733845 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 22731845 - 22733845 | GSE27584 |
chr7 |
Promoter: 22731845 - 22733845 | PMID:18759290 |