Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

3627

Name

CXCL10

Synonymous

C7|IFI10|INP10|IP-10|SCYB10|crg-2|gIP-10|mob-1;chemokine (C-X-C motif) ligand 10;CXCL10;chemokine (C-X-C motif) ligand 10

Definition

10 kDa interferon gamma-induced protein|C-X-C motif chemokine 10|gamma IP10|gamma-IP10|interferon-inducible cytokine IP-10|protein 10 from interferon (gamma)-induced cell line|small inducible cytokine subfamily B (Cys-X-Cys), member 10|small-inducible cyt

Position

4q21

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr4:76942273-76944650chr4:76943296-76943296rs4859587Single_Nucleotides|eQTL|ASAHL, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|DNase-seq|Jurkat, Chromatin_Structure|FAIRE|Gm12891, Protein_Binding|ChIP-seq|SMARCA4
chr4:76942273-76944650chr4:76943677-76943677rs4859588Single_Nucleotides|eQTL|ASAHL, Single_Nucleotides|eQTL|ASAHL, Single_Nucleotides|eQTL|CXCL11, Single_Nucleotides|eQTL|SLC6A20, Motifs|PWM|GR, Motifs|PWM|C/EBPgamma, Protein_Binding|ChIP-seq|RFX3, Protein_Binding|ChIP-seq|SMARCA4

Transcription Factors   [Top]

Regulation From TransFac database

IGFBP-7(m) + IP-10(h) <==> IGFBP-7(m):IP-10(h) (binding)
CXCL10(h) --> IP-10(h) (expression).
IFNgamma(m.s.) --> IP-10(h) (increase of abundance)
IFNgamma(h) --> IP-10(h) (increase of abundance)
IFNgamma(h) --> IP-10(h) (increase of secretion)
TNF-alpha(h) --> IP-10(h) (increase of secretion)
3pRNA --> IP-10(h) (increase of secretion)
IFNbeta(h) --> IP-10(h) (increase of abundance)
CXCL10(h) --> IP-10(h) (expression).

Post Transcriptional Modification   [Top]

There is no record for CXCL10

Methylation Profile   [Top]

There is no record for CXCL10



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