| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3952 |
Name | LEP |
Synonymous | LEPD|OB|OBS;leptin;LEP;leptin |
Definition | leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese protein|obese, mouse, homolog of|obesity factor |
Position | 7q31.3 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for LEP | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
leptin(h) --> Shc-1-p46(h){pY} (increase of phosphorylation) | leptin(h) --> Shc-1-p52(h){pY} (increase of phosphorylation) | leptin(h) --> Shc-1(h):Grb-2(h) (increase of binding) | leptin(h) --> ERK(h){p} (increase of phosphorylation) | leptin(h) --> LIF(h) (increase of secretion) | LEP(h) --> leptin(h) (expression). | HKIII(r) + leptin(h) <==> HKIII(r):leptin(h) (binding) | leptin(h) --> AMPKalpha-2(h){pT172} (increase of phosphorylation) | leptin(h) --> AMPKalpha-1(h){pT172} (increase of phosphorylation) | leptin(h) --> PPARA(m) (transactivation) | leptin(h) + lepr-A(m) <==> leptin(h):lepr-A(m) (binding) | leptin(h) --> STAT3(h){pY} (increase of phosphorylation) | leptin(h) --> CKII-beta(m) (increase of abundance) | leptin(h) --> STAT3(h){p} (increase of phosphorylation) | leptin(h) --> IRS-1(h){pY} (increase of phosphorylation) | leptin(h) --> Sam68(h){pY} (increase of phosphorylation) | leptin(h) --> ERK1(h){pT}{pY} (increase of phosphorylation) | leptin(h) --> ERK2(h){pT}{pY} (increase of phosphorylation) | leptin(h) --> STAT3(h){pY705} (increase of phosphorylation) | leptin(h) --> CCND1(h) (transactivation) | leptin(h) --> SOCS1(h) (transactivation) | leptin(h) --> SOCS3(h) (transactivation) | leptin(h) --/ SLC2A4(h) (transrepression) | leptin(h) --/ IRS1(h) (transrepression) | leptin(h) --/ ADIPOQ(h) (transrepression) | leptin(h) --/ FASN(h) (transrepression) | leptin(h) --/ LPL(h) (transrepression) | leptin(h) --/ LIPE(h) (transrepression) | leptin(h) --/ PPARG(h) (transrepression) | leptin(h) --> ERK1(h){pT202}{pY204} (increase of phosphorylation) | leptin(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | leptin(h) --> p38(h){pT}{pY} (increase of phosphorylation) | leptin(h) --> JNK(h){pT}{pY} (increase of phosphorylation) | leptin(h) + lepr-E(h) <==> leptin(h):lepr-E(h) (binding) | leptin(h) + lepr(h) <==> leptin(h):lepr(h) (binding) | leptin(h) --/ STAR(h) (transrepression) | LEP(h) --> leptin(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for LEP | |||
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 127667067 - 127669067 | Agilent_014791 |
chr7 |
Promoter: 127667067 - 127669067 | GSE27584 |
chr7 |
Promoter: 127667067 - 127669067 | Agilent_014791_44K |
chr7 |
Promoter: 127667067 - 127669067 | E-GEOD-20553 |