Entrez Gene

Basic Information
Gene ID	4035
Name	LRP1
Synonymous	A2MR\|APOER\|APR\|CD91\|IGFBP3R\|LRP\|LRP1A\|TGFBR5;low density lipoprotein receptor-related protein 1;LRP1;low density lipoprotein receptor-related protein 1
Definition	LRP-1\|TbetaR-V/LRP-1/IGFBP-3 receptor\|alpha-2-macroglobulin receptor\|apolipoprotein E receptor\|prolow-density lipoprotein receptor-related protein 1\|type V tgf-beta receptor
Position	12q13.3
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr12:57522276-57607134	chr12:57530670-57530670	rs4759044	Single_Nucleotides\|eQTL\|MARCH9, Single_Nucleotides\|eQTL\|STAT6, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|PWM\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|Footprinting\|Nkx6-2, Motifs\|PWM\|Obox2, Chromatin_Structure\|DNase-seq\|Stellate, Chromatin_Structure\|DNase-seq\|Hsmm, Chromatin_Structure\|DNase-seq\|Osteobl, Chromatin_Structure\|DNase-seq\|Fibrop, Chromatin_Structure\|DNase-seq\|Panisd, Chromatin_Structure\|DNase-seq\|Hipe, Chromatin_Structure\|DNase-seq\|Hnpce, Chromatin_Structure\|DNase-seq\|Ag09309, Chromatin_Structure\|DNase-seq\|Melano, Chromatin_Structure\|DNase-seq\|Nhdfad, Chromatin_Structure\|DNase-seq\|Hae, Chromatin_Structure\|DNase-seq\|Hcfaa
chr12:57522276-57607134	chr12:57531632-57531632	rs4367982	Single_Nucleotides\|eQTL\|MARCH9, Chromatin_Structure\|DNase-seq\|Gm19240
chr12:57522276-57607134	chr12:57533690-57533690	rs4759277	Single_Nucleotides\|eQTL\|MARCH9, Single_Nucleotides\|eQTL\|STAT6, Single_Nucleotides\|eQTL\|STAT6, Chromatin_Structure\|FAIRE\|Htr8, Chromatin_Structure\|DNase-seq\|Huh75, Chromatin_Structure\|DNase-seq\|Hnpce, Chromatin_Structure\|DNase-seq\|Gm19240, Chromatin_Structure\|DNase-seq\|Huh7, Chromatin_Structure\|DNase-seq\|Gm12891, Chromatin_Structure\|DNase-seq\|Hpaf, Chromatin_Structure\|DNase-seq\|Hcm, Chromatin_Structure\|DNase-seq\|Monocd14, Chromatin_Structure\|DNase-seq\|Hl60, Chromatin_Structure\|DNase-seq\|Hae
chr12:57522276-57607134	chr12:57534470-57534470	rs1466535	Single_Nucleotides\|eQTL\|MARCH9, Single_Nucleotides\|eQTL\|STAT6, Chromatin_Structure\|DNase-seq\|Hgf
chr12:57522276-57607134	chr12:57593894-57593894	rs1800159	Single_Nucleotides\|eQTL\|PIP5K2C, Chromatin_Structure\|DNase-seq\|Chorion, Chromatin_Structure\|DNase-seq\|Gm12892, Chromatin_Structure\|DNase-seq\|Gm12891, Chromatin_Structure\|DNase-seq\|T47d, Chromatin_Structure\|DNase-seq\|Hepatocytes, Chromatin_Structure\|DNase-seq\|Huh75, Chromatin_Structure\|DNase-seq\|Lncap, Chromatin_Structure\|DNase-seq\|Medullo, Chromatin_Structure\|DNase-seq\|H1hesc, Chromatin_Structure\|DNase-seq\|Ips, Chromatin_Structure\|DNase-seq\|Hsmmt, Chromatin_Structure\|DNase-seq\|8988t, Chromatin_Structure\|DNase-seq\|Osteobl, Chromatin_Structure\|DNase-seq\|Gm19240, Chromatin_Structure\|DNase-seq\|Gm19239, Chromatin_Structure\|DNase-seq\|Hmec, Chromatin_Structure\|DNase-seq\|Lncap, Chromatin_Structure\|DNase-seq\|Panislets, Chromatin_Structure\|DNase-seq\|Gm19238

Regulation From TransFac database
Transcription Factors [Top]
C4BP(h) + CD91(h) <==> C4BP(h):CD91(h) (binding)
C4BPalpha(h) + CD91(h) <==> C4BPalpha(h):CD91(h) (binding)
APP(h) + CD91(h) <==> APP(h):CD91(h) (binding)
APP695(h) + CD91(h) <==> APP695(h):CD91(h) (binding)
CD91(h) + PKCalpha(h) <==> CD91(h):PKCalpha(h) (binding)
CD91(h) + ATP --PKCalpha(h)--> CD91(h){pT16}{pS73}{pS76}{pS79} + ADP (phosphorylation)
Dab1(m.s.) + CD91(h) <==> Dab1(m.s.):CD91(h) (binding)
GULP1(m.s.) + CD91(h) <==> GULP1(m.s.):CD91(h) (binding)
CD91(h) + proHNP3(h) <==> CD91(h):proHNP3(h) (increase of internalization; binding)
CD91(h) + Lipc(r) <==> CD91(h):Lipc(r) (increase of internalization; binding; destabilization)
c-Cbl(ha) + CD91(h) <==> c-Cbl(ha):CD91(h) (binding)
beta2-integrin(h) + CD91(h) <==> beta2-integrin(h):CD91(h) (binding)
CD11B(h) + CD91(h) <==> CD11B(h):CD91(h) (binding)
LRP1(h) --> CD91(h) (expression).
CD91(h) + beta2-integrin(h) <==> CD91(h):beta2-integrin(h) (binding)
CD11B(h) + CD91(h) <==> CD11B(h):CD91(h) (binding)
alphaL-integrin(h) + CD91(h) <==> alphaL-integrin(h):CD91(h) (binding)
CD11C(h) + CD91(h) <==> CD11C(h):CD91(h) (binding)
CD11B(h):beta2-integrin(h) + CD91(h) <==> CD11B(h):beta2-integrin(h):CD91(h) (binding)
LRP1(h) --> CD91(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
114	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
136	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
185	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
239	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
274	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
357	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
446	N-linked (GlcNAc...).		Swiss-Prot 53.0
729	N-linked (GlcNAc...).		Swiss-Prot 53.0
928	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1050	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1154	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1155	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1195	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1218	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1511	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1558	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1575	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1616	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1645	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1723	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1733	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1763	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1825	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1933	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1995	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2048	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2117	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2127	N-linked (GlcNAc...).		Swiss-Prot 53.0
2472	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2502	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2521	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2539	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2601	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2620	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2638	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2815	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
2905	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3048	N-linked (GlcNAc...).		Swiss-Prot 53.0
3089	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3264	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3333	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3488	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3662	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3788	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3839	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
3953	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4075	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4125	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4179	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4278	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4279	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4364	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
4507	Phosphotyrosine (Src)	12789267	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr12	Promoter: 55807049 - 55809049	Agilent_014791
chr12	Promoter: 55807049 - 55809049	GSE27584
chr12	Promoter: 55807049 - 55809049	Agilent_014791_44K

ENCODE RegulomeDB [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]