| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4092 |
Name | SMAD7 |
Synonymous | CRCS3|MADH7|MADH8;SMAD family member 7;SMAD7;SMAD family member 7 |
Definition | MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD homolog 8|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7|hSMAD7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7 |
Position | 18q21.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr18:46446223-46477081 | chr18:46460705-46460705 | rs12967477 | Single_Nucleotides|eQTL|SMAD7, Chromatin_Structure|DNase-seq|Medullo, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|FAIRE|Gm19239 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) + Smad7(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h):Smad7(h) (binding) | Smad7(h) + Smurf-2(h) <==> Smad7(h):Smurf-2(h) (binding) | TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) + Smad7(h) + Smurf-2(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h):Smad7(h):Smurf-2(h) (binding) | Smad6(h) + Smad7(h) <==> Smad6(h):Smad7(h) (binding) | Smad7(h) + p38(h) <==> Smad7(h):p38(h) (binding) | Smad7(h) + p38(h){p} <==> Smad7(h):p38(h){p} (binding) | Smad7(h) + MKK3(h) <==> Smad7(h):MKK3(h) (binding) | Smad7(h) + TAK1(h) <==> Smad7(h):TAK1(h) (binding) | Smad7(h) + TAK1(h) + TAB1(h) <==> Smad7(h):TAK1(h):TAB1(h) (binding) | Smad7(h) + MKK3(h) + p38(h) <==> Smad7(h):MKK3(h):p38(h) (binding) | HDAC1(h) + Smad7(h) <==> Smad7(h):HDAC1(h) (binding) | Smad7(h) + acetyl-CoA --> Smad7(h){ace} + CoA (acetylation) | AIP5(h) + Smad7(h) <==> AIP5(h):Smad7(h) (binding) | Smad7(h) + Arkadia(h) <==> Smad7(h):Arkadia(h) (binding) | Smad7(h) + p300(h) <==> Smad7(h):p300(h) (binding) | Smad7(h) --> Smad7(h) (translocation) | TGFbetaR-II(m.s.):TGFbetaR-I(m.s.) + Smad7(h) <==> TGFbetaR-II(m.s.):TGFbetaR-I(m.s.):Smad7(h) (binding) | Smad7(h) + acetyl-CoA --> Smad7(h){aceK} + CoA (acetylation) | Smad7(h) + PDK1(h) <==> Smad7(h):PDK1(h) (binding) | SMAD7(h) --> Smad7(h) (expression). | Smad7(h){ace} --HDAC1(h)--> Smad7(h) + acetyl (deacetylation) | Smad7(h) --> Smad7(h) (translocation) | Smad1(h) + NTP --BMP7(h):BMPR-II(h):ActR-I(h)--> Smad1(h){p} + NDP (phosphorylation) | Smad2-L(h) + NTP --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h){p} + NDP (phosphorylation) | YAP(m) + Smad7(h) <==> YAP(m):Smad7(h) (binding) | SMAD7(h) --> Smad7(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
249 | Phosphoserine (By similarity). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr18 |
Promoter: 44730579 - 44732579 | Agilent_014791 |
chr18 |
Promoter: 44730579 - 44732579 | GSE27584 |
chr18 |
Promoter: 44730579 - 44732579 | Agilent_014791_44K |