| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 4313 |
Name | MMP2 |
Synonymous | CLG4|CLG4A|MMP-II|MONA|TBE-1;matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase);MMP2;matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
Definition | 72 kDa gelatinase|72 kDa type IV collagenase|MMP-2|collagenase type IV-A|gelatinase A|matrix metalloproteinase-2|matrix metalloproteinase-II|neutrophil gelatinase |
Position | 16q13-q21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr16:55423612-55540603 | chr16:55511537-55511537 | rs243866 | Single_Nucleotides|eQTL|AYTL1, Motifs|Footprinting|ER, Motifs|PWM|ER, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Gm19239 | chr16:55423612-55540603 | chr16:55511806-55511806 | rs243865 | Single_Nucleotides|eQTL|AYTL1, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Panislets, Chromatin_Structure|DNase-seq|T47d | chr16:55423612-55540603 | chr16:55512322-55512322 | rs243864 | Single_Nucleotides|eQTL|AYTL1, Motifs|Footprinting|ERRalpha, Motifs|PWM|ERRalpha, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|H1hesc | chr16:55423612-55540603 | chr16:55517162-55517162 | rs1477017 | Single_Nucleotides|eQTL|AYTL1, Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|Footprinting|ARP-1(COUP-TF2), Motifs|PWM|ARP-1(COUP-TF2), Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Hepatocytes | chr16:55423612-55540603 | chr16:55517232-55517232 | rs865094 | Single_Nucleotides|eQTL|AYTL1, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|FAIRE|Astrocy | chr16:55423612-55540603 | chr16:55518877-55518877 | rs11646643 | Single_Nucleotides|eQTL|AYTL1, Chromatin_Structure|DNase-seq|Cll, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|DNase-seq|Panislets, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|FAIRE|Urotsa, Chromatin_Structure|FAIRE|UrotsaUt189 | chr16:55423612-55540603 | chr16:55521725-55521725 | rs9302671 | Single_Nucleotides|eQTL|AYTL1, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|FAIRE|Astrocy, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Osteobl | chr16:55423612-55540603 | chr16:55523705-55523705 | rs243849 | Single_Nucleotides|eQTL|AYTL1, Chromatin_Structure|DNase-seq|Caco2 | chr16:55423612-55540603 | chr16:55529411-55529411 | rs243839 | Single_Nucleotides|eQTL|AYTL1, Motifs|PWM|FXR/RXR-alpha, Chromatin_Structure|DNase-seq|Stellate, Protein_Binding|ChIP-seq|IKZF1 | chr16:55423612-55540603 | chr16:55536763-55536763 | rs11541998 | Single_Nucleotides|eQTL|AYTL1, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|H7es, Protein_Binding|ChIP-seq|TCF4, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|CTCF |
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Transcription Factors [Top] |
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Regulation From TransFac database |
TSP-1(h) + mmp2(h) <==> TSP-1(h):mmp2(h) (binding) | TSP-2(m) + mmp2(h) <==> TSP-2(m):mmp2(h) (binding) | mmp2(h) --> mmp2-p62(h) + protein remnants (cleavage) | PROC(h) --> mmp2(h) (activation) | MMP2(h) --> mmp2(h) (expression). | p53-isoform1(h) --> mmp2(h) (increase of abundance) | fibronectin(h) --> mmp2(h) (increase of abundance) | IL-17A(h) --> mmp2(h) (increase of abundance) | estradiol --> mmp2(h) (increase of abundance) | mmp2(h) --MT3-MMP(h)--> protein remnants (cleavage) | MMP2(h) --> mmp2(h) (expression). | ADAMTS-1-p87(m.s.) --mmp2(h)--> ADAMTS-1-p65(m.s.) + protein remnants (cleavage) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
573 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 642 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr16 |
Promoter: 54069089 - 54071089 | GoldenGate_Methylation_Cancer_Panel_I |
chr16 |
Promoter: 54069089 - 54071089 | GSE27584 |
chr16 |
Promoter: 54069089 - 54071089 | Agilent_014791_44K |