Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4775

Name

NFATC3

Synonymous

NFAT4|NFATX;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3;NFATC3;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

Definition

NF-ATc3|T cell transcription factor NFAT4|nuclear factor of activated T-cells c3 isoform IE-Xa|nuclear factor of activated T-cells, cytoplasmic 3

Position

16q22.2

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr16:68118654-68263162chr16:68127278-68127278rs1074143Single_Nucleotides|eQTL|RLTPR, Chromatin_Structure|DNase-seq|Hl60
chr16:68118654-68263162chr16:68136622-68136622rs8058690Single_Nucleotides|eQTL|RLTPR, Chromatin_Structure|DNase-seq|Gm06990, Protein_Binding|ChIP-seq|EBF1, Protein_Binding|ChIP-seq|EBF1
chr16:68118654-68263162chr16:68150527-68150527rs12447640Single_Nucleotides|eQTL|RLTPR, Motifs|PWM|Zscan4, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Hasp, Protein_Binding|ChIP-seq|CTCF
chr16:68118654-68263162chr16:68152035-68152035rs12599880Single_Nucleotides|eQTL|RLTPR, Chromatin_Structure|DNase-seq|Gm12865

Transcription Factors   [Top]

Regulation From TransFac database

NF-AT4(h) + CKI-alpha(h) <==> NF-AT4(h):CKI-alpha(h) (binding)
JNK2(h) + NF-AT4(h) <==> JNK2(h):NF-AT4(h) (binding)
NF-AT4(h) + calcineurin(r) <==> NF-AT4(h):calcineurin(r) (binding)
NF-AT4(h) + SRC3(h) <==> NF-AT4(h):SRC3(h) (binding)
NF-AT4(h) --> Acta2(m) (DNA binding).
NFATC3(h) --> NF-AT4(h) (expression).
NF-AT4(h) --> Il2(m) (DNA binding).
NF-AT4(h) --> IL-5(m) (DNA binding).
NF-AT4(h) --> NPPB(h) (DNA binding).
NF-AT4(h) --> IL2(h) (DNA binding).
NF-AT4(h) --> Sftpd(m) (DNA binding; transactivation).
NFATC3(h) --> NF-AT4(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

163Phosphoserine (MAPK9)9374467Phospho.ELM 6.0
165Phosphoserine (MAPK9)9374467Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr16

Promoter: 66675376 - 66677376Agilent_014791

chr16

Promoter: 66675376 - 66677376GSE27584

chr16

Promoter: 66675376 - 66677376GSE27584

chr16

Promoter: 66675376 - 66677376GSE27584

chr16

Promoter: 66675376 - 66677376GSE27584

chr16

Promoter: 66675376 - 66677376Agilent_014791


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