Entrez Gene

Basic Information
Gene ID	4791
Name	NFKB2
Synonymous	H2TF1\|LYT-10\|LYT10\|NF-kB2\|p105\|p52;nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100);NFKB2;nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Definition	DNA-binding factor KBF2\|lymphocyte translocation chromosome 10 protein\|nuclear factor NF-kappa-B p100 subunit\|nuclear factor of kappa light chain gene enhancer in B-cells 2\|oncogene Lyt-10
Position	10q24
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB [Top]
	There is no record for NFKB2

Regulation From TransFac database
Transcription Factors [Top]
2 NF-kappaB2 (p49)(h) <==> NF-kappaB2 (p49)(h):NF-kappaB2 (p49)(h) (binding).
NF-kappaB2 (p49)(h) + RelA-p65(h) <==> NF-kappaB2 (p49)(h):RelA-p65(h) (binding).
NFKB2(h) --> NF-kappaB2 (p49)(h) (expression).
c-Rel(h) + NF-kappaB2-p100(h) <==> c-Rel(h):NF-kappaB2-p100(h) (binding).
NF-kappaB2-p100(h) + NF-kappaB1-p50(h) <==> NF-kappaB2-p100(h):NF-kappaB1-p50(h) (binding).
NF-kappaB2-p100(h) + RelA-p65(h) <==> NF-kappaB2-p100(h):RelA-p65(h) (binding).
NF-kappaB2-p100(h) --> NF-kappaB2-p52(h) + protein remnants (processing)
NF-kappaB2-p100(h) + 2 ATP --NIK(h)--> NF-kappaB2-p100(h){pS866}{pS870} + 2 ADP (phosphorylation)
NF-kappaB2-p100(h) + n ubiquitin(h) --> NF-kappaB2-p100(h){ub(n)} (ubiquitination)
NF-kappaB2-p100(h) + NIK(h) <==> NF-kappaB2-p100(h):NIK(h) (binding)
NF-kappaB2-p100(h) + ATP --> NF-kappaB2-p100(h){pS866} + ADP (phosphorylation)
NF-kappaB2-p100(h) + 3 ATP --> NF-kappaB2-p100(h){pS866}{pS870}{pS872} + 3 ADP (phosphorylation)
NF-kappaB2-p100(h) + IKK-alpha(m.s.) <==> NF-kappaB2-p100(h):IKK-alpha(m.s.) (binding)
NF-kappaB2-p100(h) + n ubiquitin(h) --> NF-kappaB2-p100(h){ub}n (ubiquitination)
beta-TrCP1(h) + NF-kappaB2-p100(h) <==> beta-TrCP1(h):NF-kappaB2-p100(h) (binding)
NF-kappaB2-p100(h) + ATP --IKK-alpha(m.s.)--> NF-kappaB2-p100(h){pS872} + ADP (phosphorylation)
NF-kappaB2-p100(h) + 4 ATP --IKK-alpha(m.s.)--> NF-kappaB2-p100(h){pS99}{pS108}{pS115}{pS123} + 4 ADP (phosphorylation)
NF-kappaB2-p100(h) + RelB(h) <==> NF-kappaB2-p100(h):RelB(h) (binding)
NF-kappaB2-p100(h) + n ubiquitin(h) --> NF-kappaB2-p100(h){ub(n)K855} (ubiquitination)
IKK-alpha(h) + NF-kappaB2-p100(h) <==> IKK-alpha(h):NF-kappaB2-p100(h) (binding)
NFKB2(h) --> NF-kappaB2-p100(h) (expression).
TNF-alpha(h) --> NF-kappaB2-p100(h) (increase of abundance)
TNF(h) --> NF-kappaB2-p100(h) (increase of abundance)
LIGHT(h) --/ NF-kappaB2-p100(h) (decrease of abundance)
LT-betaR(h) --/ NF-kappaB2-p100(h) (decrease of abundance)
RelB(h) + NF-kappaB1-p50(h) + NF-kappaB2(h) <==> RelB(h):NF-kappaB1-p50(h):NF-kappaB2(h) (binding)
NF-kappaB2(h) --> CCL19(h) (DNA binding).
NF-kappaB2(h) --> CXCL13(h) (DNA binding).
NF-kappaB2(h) --> TNFSF13B(h) (DNA binding).
NFKB2(h) --> NF-kappaB2(h) (expression).
Murr1(h) --/ NF-kappaB2(h) (decrease of abundance)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
713	Phosphoserine.		Swiss-Prot 53.0
715	Phosphoserine.		Swiss-Prot 53.0
717	Phosphoserine.		Swiss-Prot 53.0
866	Phosphoserine (by MAP3K14).		Swiss-Prot 53.0
870	Phosphoserine (by MAP3K14).		Swiss-Prot 53.0
872	Phosphoserine (IKK-alpha)	15310758	Phospho.ELM 6.0
866	Phosphoserine (MAP4K4;MAP3K)	11239468	Phospho.ELM 6.0
870	Phosphoserine (MAP4K4;MAP3K)	11239468	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr10	Promoter: 104143922 - 104145922	Agilent_014791
chr10	Promoter: 104142829 - 104144829	GoldenGate_Methylation_Cancer_Panel_I
chr10	Promoter: 104143922 - 104145922	GoldenGate_Methylation_Cancer_Panel_I
chr10	Promoter: 104142719 - 104144719	GSE27584
chr10	Promoter: 104142829 - 104144829	GSE27584
chr10	Promoter: 104143922 - 104145922	GSE27584
chr10	Promoter: 104142719 - 104144719	Agilent_014791_44K

ENCODE RegulomeDB [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]