| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4846 |
Name | NOS3 |
Synonymous | ECNOS|eNOS;nitric oxide synthase 3 (endothelial cell);NOS3;nitric oxide synthase 3 (endothelial cell) |
Definition | EC-NOS|NOS type III|NOSIII|cNOS|constitutive NOS|endothelial NOS|nitric oxide synthase, endothelial |
Position | 7q36 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for NOS3 | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
calmodulin(h) + eNOS(h) <==> calmodulin(h):eNOS(h) (binding) | eNOS(h) + ATP --> eNOS(h){pS1179} + ADP (phosphorylation) | Strn(m.s.) + eNOS(h) <==> Strn(m.s.):eNOS(h) (binding) | eNOS(h) + Striatin(h) <==> eNOS(h):Striatin(h) (binding) | eNOS(h) + ATP --> eNOS(h){p} + ADP (phosphorylation) | Hsp90(h) + eNOS(h) <==> Hsp90(h):eNOS(h) (binding) | eNOS(h) + ATP --> eNOS(h){pS1177} + ADP (phosphorylation) | eNOS(h) + ATP --> eNOS(h){pS633} + ADP (phosphorylation) | caveolin-1(h) + eNOS(h) + nostrin(h) <==> caveolin-1(h):eNOS(h):nostrin(h) (binding) | endoglin(h) + Hsp90(h) + caveolin-1(h) + eNOS(h) <==> endoglin(h):Hsp90(h):caveolin-1(h):eNOS(h) (binding) | AKT-1(b) --> eNOS(h) (phosphorylation) | estradiol:ER-alpha(h) --> eNOS(h) (activation) | NOS3(h) --> eNOS(h) (expression). | 15d-PGJ2 --/ eNOS(h) (decrease of abundance) | CRP(h) --/ eNOS(h) (decrease of abundance) | G-CSF(m.s.) --> eNOS(h) (increase of abundance) | serotonin --> eNOS(h) (increase of abundance) | endoglin(h) --> eNOS(h) (activation; increase of abundance) | L-arginine + 3/2 O2 + 3/2 NADPH + 3/2 H+ <--eNOS(h)--> L-citrulline + NO + 2 H2O + NADP+ | NOS3(h) --> eNOS(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-myristoyl glycine (By similarity). | Swiss-Prot 53.0 | 15 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 26 | S-palmitoyl cysteine (By similarity). | Swiss-Prot 53.0 | 495 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 633 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 1175 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 1177 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 494 | Phosphothreonine | 16126727 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 150317580 - 150319580 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 150317580 - 150319580 | GSE27584 |