Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

51144

Name

HSD17B12

Synonymous

KAR|SDR12C1;hydroxysteroid (17-beta) dehydrogenase 12;HSD17B12;hydroxysteroid (17-beta) dehydrogenase 12

Definition

17-beta-HSD 12|17-beta-hydroxysteroid dehydrogenase 12|17beta-HSD type 12|3-ketoacyl-CoA reductase|estradiol 17-beta-dehydrogenase 12|short chain dehydrogenase/reductase family 12C, member 1|steroid dehydrogenase homolog

Position

11p11.2

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr11:43577986-43878167chr11:43635734-43635734rs10768966Single_Nucleotides|eQTL|HSD17B12, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|SETDB1
chr11:43577986-43878167chr11:43653833-43653833rs2862996Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Sknmc, Chromatin_Structure|DNase-seq|8988t, Protein_Binding|ChIP-seq|FOS, Protein_Binding|ChIP-seq|JUN
chr11:43577986-43878167chr11:43660255-43660255rs9783304Single_Nucleotides|eQTL|HSD17B12, Protein_Binding|ChIP-seq|RFX3
chr11:43577986-43878167chr11:43671734-43671734rs11037537Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Caco2, Protein_Binding|ChIP-seq|AR, Protein_Binding|ChIP-seq|GATA6
chr11:43577986-43878167chr11:43696316-43696316rs6485443Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Jurkat
chr11:43577986-43878167chr11:43721672-43721672rs12277307Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|K562, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1
chr11:43577986-43878167chr11:43747912-43747912rs12800235Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|H7es, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA6
chr11:43577986-43878167chr11:43754372-43754372rs10768975Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Rptec
chr11:43577986-43878167chr11:43760607-43760607rs4755735Single_Nucleotides|eQTL|HSD17B12, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|Footprinting|GATA-1, Motifs|PWM|GATA-1, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hct116, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Hpf, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Ag04450, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Ag09319, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|DNase-seq|Be2c, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Sknmc, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|FAIRE|Astrocy, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|TFAP2A, Protein_Binding|ChIP-seq|TFAP2C, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|SPI1, Protein_Binding|ChIP-seq|SIX5, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|SPI1, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|GATA3, Protein_Binding|ChIP-seq|SMARCA4
chr11:43577986-43878167chr11:43768254-43768254rs10742688Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hl60, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|MAX, Protein_Binding|ChIP-seq|TAL1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|MAX, Protein_Binding|ChIP-seq|JUNB, Protein_Binding|ChIP-seq|JUND
chr11:43577986-43878167chr11:43769295-43769295rs7115970Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|K562, Protein_Binding|ChIP-seq|SMARCA4, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|SMARCA4, Protein_Binding|ChIP-seq|SMARCB1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|GATA6, Protein_Binding|ChIP-seq|MYC, Protein_Binding|ChIP-seq|CCNT2, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|POLR2A
chr11:43577986-43878167chr11:43773813-43773813rs10768976Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Motifs|PWM|ISGF-3, Protein_Binding|ChIP-seq|RFX3
chr11:43577986-43878167chr11:43775734-43775734rs4643069Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|T47d
chr11:43577986-43878167chr11:43825481-43825481rs6485464Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|FAIRE|Astrocy, Chromatin_Structure|DNase-seq|Nhdfneo
chr11:43577986-43878167chr11:43839935-43839935rs10768983Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|FAIRE|Nhek, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Hipe
chr11:43577986-43878167chr11:43846850-43846850rs7131110Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Ag04450, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|FAIRE|H1hesc, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Ag04449, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|SMC3, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|CTCF
chr11:43577986-43878167chr11:43868651-43868651rs939015Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmveclbl
chr11:43577986-43878167chr11:43873539-43873539rs1518820Single_Nucleotides|eQTL|HSD17B12, Single_Nucleotides|eQTL|HSD17B12, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|FAIRE|K562, Chromatin_Structure|FAIRE|Gm19239, Chromatin_Structure|FAIRE|Htr8, Chromatin_Structure|DNase-seq|Gliobla

Transcription Factors   [Top]

Regulation From TransFac database

HSD17B12(h) --> estradiol 17-beta-dehydrogenase 12(h) (expression).
HSD17B12(h) --> estradiol 17-beta-dehydrogenase 12(h) (expression).

Post Transcriptional Modification   [Top]

There is no record for HSD17B12

Methylation Profile   [Top]

Chromosome

Location

Source

chr11

Promoter: 43657381 - 43659381Agilent_014791

chr11

Promoter: 43657381 - 43659381GoldenGate_Methylation_Cancer_Panel_I

chr11

Promoter: 43657381 - 43659381GSE27584

chr11

Promoter: 43657381 - 43659381Agilent_014791_44K


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