| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5594 |
Name | MAPK1 |
Synonymous | ERK|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk;mitogen-activated protein kinase 1;MAPK1;mitogen-activated protein kinase 1 |
Definition | ERK-2|MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|p42-MAPK|protein tyrosine kinase ERK2 |
Position | 22q11.21 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr22:22108789-22221970 | chr22:22112527-22112527 | rs9610271 | Single_Nucleotides|eQTL|NA, Motifs|Footprinting|STAT1, Motifs|Footprinting|STAT1, Motifs|PWM|STAT1, Motifs|Footprinting|STAT1, Motifs|Footprinting|STAT3, Motifs|Footprinting|STAT3, Motifs|PWM|STAT1, Motifs|PWM|STAT3, Motifs|Footprinting|STAT1, Motifs|Footprinting|STAT1, Motifs|PWM|STAT1, Motifs|Footprinting|P50:P50, Motifs|PWM|Hbp1, Motifs|PWM|P50:P50, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hpaf | chr22:22108789-22221970 | chr22:22136398-22136398 | rs9607272 | Single_Nucleotides|eQTL|MAPK1, Chromatin_Structure|DNase-seq|Jurkat | chr22:22108789-22221970 | chr22:22209139-22209139 | rs9610470 | Single_Nucleotides|eQTL|MAPK1, Motifs|PWM|Myf6, Chromatin_Structure|DNase-seq|Panisd | chr22:22108789-22221970 | chr22:22213969-22213969 | rs9610487 | Single_Nucleotides|eQTL|MAPK1, Single_Nucleotides|eQTL|MAPK1, Motifs|PWM|PTF1-beta, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Hl60 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
p53(h) + ERK2(h) <==> p53(h):ERK2(h) (binding) | ERK2(h) + ATP --> ERK2(h){p} + ADP (phosphorylation) | ERK2(h) + Mnk1(m) <==> ERK2(h):Mnk1(m) (binding) | ERK2(h) + MNK2(m) <==> ERK2(h):MNK2(m) (binding) | ERK2(h) + SK1(h) <==> ERK2(h):SK1(h) (binding) | ERK2(h) + RSK1(h) <==> ERK2(h):RSK1(h) (binding) | ERK2(h) + RSK1(v.s.) <==> ERK2(h):RSK1(v.s.) (binding) | ERK2(h) + RSK2(h) <==> ERK2(h):RSK2(h) (binding) | ERK2(h) + RSK3(h) <==> ERK2(h):RSK3(h) (binding) | gamma-synuclein(h) + ERK2(h) <==> gamma-synuclein(h):ERK2(h) (binding) | ERK2(h) + NACP(h) <==> ERK2(h):NACP(h) (binding) | ERK2(h) + ATP --MEK(h)--> ERK2(h){p} + ADP (phosphorylation) | ERK2(h) + ATP --MEK1(h)--> ERK2(h){p} + ADP (phosphorylation) | PTP-SL(m) + ERK2(h) <==> PTP-SL(m):ERK2(h) (binding) | STEP(r) + ERK2(h) <==> STEP(r):ERK2(h) (binding) | ERK2(h) --> BIRC3(m.s.) (transactivation) | ERK2(h) + 2 ATP --> ERK2(h){pT185}{pY187} + 2 ADP (phosphorylation) | ERK2(h) + ATP --> ERK2(h){pY} + ADP (phosphorylation) | HEPTP(h) + ERK2(h) <==> HEPTP(h):ERK2(h) (binding) | IQGAP1(h) + ERK2(h) <==> IQGAP1(h):ERK2(h) (binding) | PDE4D(h) + ERK2(h) <==> PDE4D(h):ERK2(h) (binding) | ERK2(h) --> Fyn(m.s.):Map-2c(h) (decrease of binding) | Naf1alpha(h) + ERK2(h) <==> Naf1alpha(h):ERK2(h) (binding) | NURR1(h) + ERK2(h) <==> NURR1(h):ERK2(h) (binding) | ERK2(h) + MSK1(h) <==> ERK2(h):MSK1(h) (binding) | ERK2(h) + 2 ATP --> ERK2(h){pT}{pY} + 2 ADP (phosphorylation) | ERK2(h) --> MIP1A(h):CKR-5(h) (increase of binding) | ERK2(h) + MKP-1(h) <==> ERK2(h):MKP-1(h) (binding) | ERK2(h) + p300(h) <==> ERK2(h):p300(h) (binding) | ERK2(h) + 2 ATP --> ERK2(h){p}2 + 2 ADP (phosphorylation) | ERK2(h) + ATP --> ERK2(h){pY187} + ADP (phosphorylation) | ERK2(h) + STAT1alpha(h) <==> ERK2(h):STAT1alpha(h) (binding) | Vav(h) + ERK2(h) <==> Vav(h):ERK2(h) (binding) | IL-8(h):CXCR2(h):G-alpha-i2(h) --> ERK2(h) (activation; phosphorylation) | IL-8(h):CXCR1(h):G-alpha-i2(h) --> ERK2(h) (activation; phosphorylation) | MAPK1(h) --> ERK2(h) (expression). | DEFA1(h) --> ERK2(h) (activation) | proHNP3(h) --> ERK2(h) (activation) | catalase(m.s.) --> ERK2(h) (regulation of abundance) | NT(m.s.) --> ERK2(h) (increase of phosphorylation) | ERK2(h){pT185}{pY187} --DUSP5(m.s.)--> ERK2(h) + 2 p (dephosphorylation) | MITF(h) + ATP --ERK2(h)--> MITF(h){pS73} + ADP (phosphorylation) | Sp1(h) + ATP --ERK2(h)--> Sp1(h){pT453}{pT739} + ADP (phosphorylation) | tankyrase-1(h) + ATP --ERK2(h)--> tankyrase-1(h){pS} + ADP (phosphorylation) | arachidonate 5-lipoxygenase(h) + ATP --ERK2(h)--> arachidonate 5-lipoxygenase(h){p} + ADP (phosphorylation) | BOD-L(r) + ATP --ERK2(h)--> BOD-L(r){p} + ADP (phosphorylation) | Bcl-2(h) + ATP --ERK2(h)--> Bcl-2(h){pS70} + ADP (phosphorylation) | HDAC4(h) + ATP --ERK2(h)--> HDAC4(h){p} + ADP (phosphorylation) | Elk-1(m.s.) + ATP --ERK2(h)--> Elk-1(m.s.){p} + ADP (phosphorylation) | Elk-1(h) + ATP --ERK2(h)--> Elk-1(h){p} + ADP (phosphorylation) | ER-alpha(m.s.) + ATP --ERK2(h)--> ADP + ER-alpha(m.s.){p} (phosphorylation) | ER-alpha(h) + ATP --ERK2(h)--> ER-alpha(h){p} + ADP (phosphorylation) | c-Myc(h) + ATP --ERK2(h)--> c-Myc(h){p} + ADP (phosphorylation) | Map-2c(h) + 2 ATP --ERK2(h)--> Map-2c(h){pT293}{pS297} + 2 ADP (phosphorylation) | MBP(m.s.) + ATP --ERK2(h)--> MBP(m.s.){p} + ADP (phosphorylation) | Elk-1(m.s.) + ATP --ERK2(h)--> Elk-1(m.s.){pS383} + ADP (phosphorylation) | Elk1-isoform1(h) + ATP --ERK2(h)--> Elk1-isoform1(h){pS383} + ADP (phosphorylation) | ERK2(h) + 2 ATP --> ERK2(h){pT185}{pY187} + 2 ADP (phosphorylation) | ERK2(h) + 2 ATP --> ERK2(h){p}2 + 2 ADP (phosphorylation) | Naf1(h) + ERK2(h) <==> Naf1(h):ERK2(h) (binding) | Naf1alpha(h) + ERK2(h) <==> Naf1alpha(h):ERK2(h) (binding) | MAPK1(h) --> ERK2(h) (expression). | PDE4D3(h) + ATP --ERK2(h)--> PDE4D3(h){p} + ADP (phosphorylation) | PDE4D1(m.s.) + ATP --ERK2(h)--> PDE4D1(m.s.){p} + ADP (phosphorylation) | PDE4D2(m.s.) + ATP --ERK2(h)--> PDE4D2(m.s.){p} + ADP (phosphorylation) | TAB1(h) + 2 ATP --ERK2(h)--> TAB1(h){pT431}{pS438} + 2 ADP (phosphorylation) | ERR1(h) + ATP --ERK2(h)--> ERR1(h){p} + ADP (phosphorylation) | tppp(h) + 2 ATP --ERK2(h)--> tppp(h){pS18}{pS160} + 2 ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-acetylalanine. | Swiss-Prot 53.0 | 185 | Phosphothreonine. | Swiss-Prot 53.0 | 187 | Phosphotyrosine. | Swiss-Prot 53.0 | 190 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 184 | Phosphothreonine (MAP2K1;MAP3K) | 9166761;11971971;15935618 | Phospho.ELM 6.0 | 186 | Phosphotyrosine (MAP2K1;JAK2;) | 1378617;15592455;16094384;11971971;15972258;159356 | Phospho.ELM 6.0 | 204 | Phosphotyrosine | 9124279 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr22 |
Promoter: 20551470 - 20553470 | Agilent_014791 |
chr22 |
Promoter: 20551470 - 20553470 | GSE27584 |
chr22 |
Promoter: 20551470 - 20553470 | GSE27584 |
chr22 |
Promoter: 20551470 - 20553470 | Agilent_014791_44K |
chr22 |
Promoter: 20551470 - 20553470 | Agilent_014791 |