| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 57142 |
Name | RTN4 |
Synonymous | ASY|NI220/250|NOGO|NOGO-A|NOGOC|NSP|NSP-CL|Nbla00271|Nbla10545|Nogo-B|Nogo-C|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C;reticulon 4;RTN4;reticulon 4 |
Definition | Human NogoA|My043 protein|foocen|neurite growth inhibitor 220|neurite outgrowth inhibitor|neuroendocrine-specific protein C homolog|reticulon 5|reticulon-4 |
Position | 2p16.3 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
|
Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr2:55199325-55339757 | chr2:55207693-55207693 | rs3198123 | Single_Nucleotides|eQTL|HSS00293720, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Lncap | chr2:55199325-55339757 | chr2:55324960-55324960 | rs4672016 | Single_Nucleotides|eQTL|FLJ31438, Motifs|Footprinting|Gata1, Motifs|Footprinting|Gata1, Motifs|Footprinting|Gata1, Motifs|Footprinting|Gata1, Motifs|Footprinting|GATA-X, Motifs|Footprinting|GATA-X, Motifs|Footprinting|GATA-X, Motifs|Footprinting|GATA-X, Motifs|PWM|GATA-X, Motifs|PWM|Gata1, Motifs|PWM|Gata6, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Cmk, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|A549, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|FOS, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|NR3C1 | chr2:55199325-55339757 | chr2:55327091-55327091 | rs2968811 | Single_Nucleotides|eQTL|FLJ31438, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|DNase-seq|Jurkat, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|FAIRE|Astrocy, Protein_Binding|ChIP-seq|STAT1, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|JUND |
|---|---|---|---|
Transcription Factors [Top] |
|
Regulation From TransFac database |
Nogo-isoform1(h) + Caspr(r) <==> Nogo-isoform1(h):Caspr(r) (binding) | Caspr(m) + Nogo-isoform1(h) + Kv1.1(m) <==> Caspr(m):Nogo-isoform1(h):Kv1.1(m) (binding) | Caspr(r) + Nogo-isoform1(h) + Kv1.1(r) <==> Caspr(r):Nogo-isoform1(h):Kv1.1(r) (binding) | RTN4(h) --> Nogo-isoform1(h) (expression). | SIRT2(h) + Nogo(h) <==> SIRT2(h):Nogo(h) (binding) | lrch4(h) + Nogo(h) <==> lrch4(h):Nogo(h) (binding) | SNAP-alpha(h) + Nogo(h) <==> SNAP-alpha(h):Nogo(h) (binding) | RabS10(h) + Nogo(h) <==> RabS10(h):Nogo(h) (binding) | FXR2(h) + Nogo(h) <==> FXR2(h):Nogo(h) (binding) | GPBP(h) + Nogo(h) <==> GPBP(h):Nogo(h) (binding) | NSPL2(h) + Nogo(h) <==> NSPL2(h):Nogo(h) (binding) | Maspardin(h) + Nogo(h) <==> Maspardin(h):Nogo(h) (binding) | Nogo(h) + plekhf2(h) <==> Nogo(h):plekhf2(h) (binding) | RTN4(h) --> Nogo(h) (expression). | RTN4(h) --> Nogo-isoform2(h) (expression). | RTN4(h) --> Nogo-isoform3(h) (expression). | RTN4(h) --> Nogo-isoform4(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
7 | Phosphoserine. | Swiss-Prot 53.0 | 15 | Phosphoserine. | Swiss-Prot 53.0 | 107 | Phosphoserine. | Swiss-Prot 53.0 | 152 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 182 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 184 | Phosphoserine. | Swiss-Prot 53.0 | 188 | Phosphothreonine. | Swiss-Prot 53.0 | 446 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 860 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 863 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 881 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 889 | Phosphotyrosine (By similarity). | Swiss-Prot 53.0 | 7 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 15 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 107 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr2 |
Promoter: 55130738 - 55132738 | Agilent_014791 |
chr2 |
Promoter: 55129330 - 55131330 | Agilent_014791 |
chr2 |
Promoter: 55130738 - 55132738 | GSE27584 |
chr2 |
Promoter: 55129330 - 55131330 | GSE27584 |
chr2 |
Promoter: 55130738 - 55132738 | GSE27584 |
chr2 |
Promoter: 55130738 - 55132738 | GSE27584 |
chr2 |
Promoter: 55129330 - 55131330 | Agilent_014791_44K |