Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

57142

Name

RTN4

Synonymous

ASY|NI220/250|NOGO|NOGO-A|NOGOC|NSP|NSP-CL|Nbla00271|Nbla10545|Nogo-B|Nogo-C|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C;reticulon 4;RTN4;reticulon 4

Definition

Human NogoA|My043 protein|foocen|neurite growth inhibitor 220|neurite outgrowth inhibitor|neuroendocrine-specific protein C homolog|reticulon 5|reticulon-4

Position

2p16.3

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr2:55199325-55339757chr2:55207693-55207693rs3198123Single_Nucleotides|eQTL|HSS00293720, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Lncap
chr2:55199325-55339757chr2:55324960-55324960rs4672016Single_Nucleotides|eQTL|FLJ31438, Motifs|Footprinting|Gata1, Motifs|Footprinting|Gata1, Motifs|Footprinting|Gata1, Motifs|Footprinting|Gata1, Motifs|Footprinting|GATA-X, Motifs|Footprinting|GATA-X, Motifs|Footprinting|GATA-X, Motifs|Footprinting|GATA-X, Motifs|PWM|GATA-X, Motifs|PWM|Gata1, Motifs|PWM|Gata6, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Cmk, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|A549, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|FOS, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|TRIM28, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|NR3C1
chr2:55199325-55339757chr2:55327091-55327091rs2968811Single_Nucleotides|eQTL|FLJ31438, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|DNase-seq|Jurkat, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hl60, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|FAIRE|Huvec, Chromatin_Structure|DNase-seq|Monocd14, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|FAIRE|Astrocy, Protein_Binding|ChIP-seq|STAT1, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|JUN, Protein_Binding|ChIP-seq|JUND

Transcription Factors   [Top]

Regulation From TransFac database

Nogo-isoform1(h) + Caspr(r) <==> Nogo-isoform1(h):Caspr(r) (binding)
Caspr(m) + Nogo-isoform1(h) + Kv1.1(m) <==> Caspr(m):Nogo-isoform1(h):Kv1.1(m) (binding)
Caspr(r) + Nogo-isoform1(h) + Kv1.1(r) <==> Caspr(r):Nogo-isoform1(h):Kv1.1(r) (binding)
RTN4(h) --> Nogo-isoform1(h) (expression).
SIRT2(h) + Nogo(h) <==> SIRT2(h):Nogo(h) (binding)
lrch4(h) + Nogo(h) <==> lrch4(h):Nogo(h) (binding)
SNAP-alpha(h) + Nogo(h) <==> SNAP-alpha(h):Nogo(h) (binding)
RabS10(h) + Nogo(h) <==> RabS10(h):Nogo(h) (binding)
FXR2(h) + Nogo(h) <==> FXR2(h):Nogo(h) (binding)
GPBP(h) + Nogo(h) <==> GPBP(h):Nogo(h) (binding)
NSPL2(h) + Nogo(h) <==> NSPL2(h):Nogo(h) (binding)
Maspardin(h) + Nogo(h) <==> Maspardin(h):Nogo(h) (binding)
Nogo(h) + plekhf2(h) <==> Nogo(h):plekhf2(h) (binding)
RTN4(h) --> Nogo(h) (expression).
RTN4(h) --> Nogo-isoform2(h) (expression).
RTN4(h) --> Nogo-isoform3(h) (expression).
RTN4(h) --> Nogo-isoform4(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

7Phosphoserine.Swiss-Prot 53.0
15Phosphoserine.Swiss-Prot 53.0
107Phosphoserine.Swiss-Prot 53.0
152Phosphoserine (By similarity).Swiss-Prot 53.0
182Phosphoserine (By similarity).Swiss-Prot 53.0
184Phosphoserine.Swiss-Prot 53.0
188Phosphothreonine.Swiss-Prot 53.0
446Phosphoserine (By similarity).Swiss-Prot 53.0
860Phosphoserine (By similarity).Swiss-Prot 53.0
863Phosphoserine (By similarity).Swiss-Prot 53.0
881Phosphoserine (By similarity).Swiss-Prot 53.0
889Phosphotyrosine (By similarity).Swiss-Prot 53.0
7Phosphoserine17081983Phospho.ELM 6.0
15Phosphoserine17081983Phospho.ELM 6.0
107Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 55130738 - 55132738Agilent_014791

chr2

Promoter: 55129330 - 55131330Agilent_014791

chr2

Promoter: 55130738 - 55132738GSE27584

chr2

Promoter: 55129330 - 55131330GSE27584

chr2

Promoter: 55130738 - 55132738GSE27584

chr2

Promoter: 55130738 - 55132738GSE27584

chr2

Promoter: 55129330 - 55131330Agilent_014791_44K


')