| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 595 |
Name | CCND1 |
Synonymous | BCL1|D11S287E|PRAD1|U21B31;cyclin D1;CCND1;cyclin D1 |
Definition | B-cell CLL/lymphoma 1|B-cell lymphoma 1 protein|BCL-1 oncogene|G1/S-specific cyclin-D1|PRAD1 oncogene |
Position | 11q13 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for CCND1 | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
cyclinD1(h) + p21Cip1(h) <==> cyclinD1(h):p21Cip1(h) (binding) | cyclinD1(h) + Cdc25C(h) <==> cyclinD1(h):Cdc25C(h) (binding) | cyclinD1(h) + Cdc25B(h) <==> cyclinD1(h):Cdc25B(h) (binding) | cyclinD1(h) + Cdc25A(h) <==> cyclinD1(h):Cdc25A(h) (binding) | cyclinD1(h) + Cdk4(h) + p16INK4a(h) + p34SEI-1(h) <==> cyclinD1(h):Cdk4(h):p16INK4a(h):p34SEI-1(h) (binding) | ER(h) + cyclinD1(h) <==> ER(h):cyclinD1(h) (binding) | cyclinD1(h) + Cdk4(h) + p21Cip1(h) <==> cyclinD1(h):Cdk4(h):p21Cip1(h) (binding) | cyclinD1(h) + HDAC1(h) <==> cyclinD1(h):HDAC1(h) (binding) | hdac2(m.s.) + cyclinD1(h) <==> hdac2(m.s.):cyclinD1(h) (binding) | HDAC3(m.s.) + cyclinD1(h) <==> HDAC3(m.s.):cyclinD1(h) (binding) | HDAC4(h) + cyclinD1(h) <==> HDAC4(h):cyclinD1(h) (binding) | HDAC5(h) + cyclinD1(h) <==> HDAC5(h):cyclinD1(h) (binding) | cyclinD1(h) + brca1(h) <==> cyclinD1(h):brca1(h) (binding) | cyclinD1(h) + AKAP95(h) <==> cyclinD1(h):AKAP95(h) (binding) | p27Kip1(h) + cyclinD1(h) + Cdk4(h) <==> p27Kip1(h):cyclinD1(h):Cdk4(h) (binding) | cyclinD1(h) + p27Kip1(h) <==> cyclinD1(h):p27Kip1(h) (binding) | ER-alpha(h) + cyclinD1(h) <==> ER-alpha(h):cyclinD1(h) (binding) | cyclinD1(h) + ATP --> cyclinD1(h){pT286} + ADP (phosphorylation) | cyclinD1(h) + Cdk4(h) <==> cyclinD1(h):Cdk4(h) (binding) | p27Kip1(h) + cyclinD1(h) <==> p27Kip1(h):cyclinD1(h) (binding) | CCND1(h) --> cyclinD1(h) (expression). | Hex(m.s.) --/ cyclinD1(h) (inhibition) | estradiol --> cyclinD1(h) (increase of abundance) | NAG-7(h) --/ cyclinD1(h) (decrease of abundance) | TR4(m.s.) --/ cyclinD1(h) (decrease of abundance) | FOXO1A(m.s.) --/ cyclinD1(h) (decrease of abundance) | C/EBPalpha(h) --/ cyclinD1(h) (decrease of abundance) | IKK-alpha(h) --> cyclinD1(h) (increase of abundance) | E2F-1(h) --> cyclinD1(h) (increase of abundance) | AR-isoform1(h) --> cyclinD1(h) (increase of abundance) | p65PAK(h) --> cyclinD1(h) (increase of abundance) | Pin1(h) --> cyclinD1(h) (increase of abundance) | NRG1(m.s.) --> cyclinD1(h) (increase of abundance) | EGF(m.s.) --> cyclinD1(h) (increase of abundance) | Tob1(h) --/ cyclinD1(h) (decrease of abundance) | Cdx-2(h) --/ cyclinD1(h) (decrease of abundance) | NRG1(h) --/ cyclinD1(h) (decrease of abundance) | EGF(h) --> cyclinD1(h) (increase of abundance) | NRG-Beta1(m.s.) --> cyclinD1(h) (increase of abundance) | PC3(m.s.) --/ cyclinD1(h) (decrease of abundance) | PC3(h) --/ cyclinD1(h) (decrease of abundance) | atad2(h) --> cyclinD1(h) (increase of abundance) | IFNgamma(m.s.) --> cyclinD1(h) (increase of abundance) | Fz6(h) --/ cyclinD1(h) (decrease of abundance) | slc7a11(h) --> cyclinD1(h) (increase of abundance) | Histatin-3(m.s.) --> cyclinD1(h) (increase of abundance) | cyclinD1a(h) + AKAP95(ca) <==> cyclinD1a(h):AKAP95(ca) (binding) | cyclinD1a(h) + Roc1(h) <==> cyclinD1a(h):Roc1(h) (binding) | cyclinD1a(h) + n ubiquitin(b) --Cul-1(m.s.):Roc1(h),Ubc5C(h),E1(rb)--> cyclinD1a(h){ub(n)} (ubiquitination) | cyclinD1a(h) + n ubiquitin(b) --Ubc5C(h),E1(rb),CUL3(m.s.):Roc1(h)--> cyclinD1a(h){ub(n)} (ubiquitination) | cyclinD1a(h) + n ubiquitin(m.s.) --> cyclinD1a(h){ub(n)} (ubiquitination) | cyclinD1a(h) --26S proteasome(h)--> protein remnants (degradation) | Cdk4(h) + cyclinD1a(h) <==> Cdk4(h):cyclinD1a(h) (binding) | cyclinD1a(h) + ATP --GSK3beta(m.s.)--> cyclinD1a(h){p} + ADP (phosphorylation) | cyclinD1a(h) + AR(m.s.) <==> cyclinD1a(h):AR(m.s.) (binding) | p/CAF(h) + cyclinD1a(h) <==> p/CAF(h):cyclinD1a(h) (binding) | ER(h) + cyclinD1a(h) <==> ER(h):cyclinD1a(h) (binding) | p/CAF(h) + ER(h) + cyclinD1a(h) <==> p/CAF(h):ER(h):cyclinD1a(h) (binding) | cyclinD1a(h) + HDAC3(m.s.) <==> cyclinD1a(h):HDAC3(m.s.) (binding) | AR-isoform1(h) + cyclinD1a(h) <==> AR-isoform1(h):cyclinD1a(h) (binding) | IA-1(h) + cyclinD1a(h) <==> IA-1(h):cyclinD1a(h) (binding) | CCND1(h) --> cyclinD1a(h) (expression). | cyclinD1b(h) + AR(h) <==> cyclinD1b(h):AR(h) (binding) | cyclinD1b(h) + AR(m.s.) <==> cyclinD1b(h):AR(m.s.) (binding) | cyclinD1b(h) + HDAC3(m.s.) <==> cyclinD1b(h):HDAC3(m.s.) (binding) | CCND1(h) --> cyclinD1b(h) (expression) | CCND1(h) --> cyclinD1(h) (expression). | hsa-miR-16 --/ cyclinD1(h) (increase of mRNA decay). | hsa-miR-17-5p --/ cyclinD1(h) (translational repression). | hsa-miR-20a --/ cyclinD1(h) (translational repression). | hsa-miR-302a --/ cyclinD1(h) (translational repression). | hsa-miR-15a --/ CCND1(h) (translational repression). | hsa-miR-16 --/ CCND1(h) (translational repression). | hsa-miR-34a --/ CCND1(h) (increase of mRNA decay). | CCND1(h) --> CCND1(h) (expression). | hsa-miR-195 --/ CCND1(h) (translational repression). | hsa-miR-424 --/ CCND1(h) (translational repression). | hsa-miR-497 --/ CCND1(h) (translational repression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 69163554 - 69165554 | Agilent_014791 |
chr11 |
Promoter: 69163554 - 69165554 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 69163554 - 69165554 | GSE27584 |
chr11 |
Promoter: 69163554 - 69165554 | Agilent_014791_44K |
chr11 |
Promoter: 69163554 - 69165554 | Agilent_014791 |
chr11 |
Promoter: 69163554 - 69165554 | PMID:16774933 |