| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 6347 |
Name | CCL2 |
Synonymous | GDCF-2|HC11|HSMCR30|MCAF|MCP-1|MCP1|SCYA2|SMC-CF;chemokine (C-C motif) ligand 2;CCL2;chemokine (C-C motif) ligand 2 |
Definition | C-C motif chemokine 2|monocyte chemoattractant protein 1|monocyte chemoattractant protein-1|monocyte chemotactic and activating factor|monocyte chemotactic protein 1|monocyte secretory protein JE|small inducible cytokine A2 (monocyte chemotactic protein 1 |
Position | 17q11.2-q12 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for CCL2 | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
CCL2(h) --> MCP-1(h) (expression). | FcgammaRI alpha(h) --> MCP-1(h) (decrease of secretion) | FcgammaRIIA(h) --> MCP-1(h) (decrease of secretion) | FCgammaRIIIA(h) --> MCP-1(h) (decrease of secretion) | Murr1(h) --/ MCP-1(h) (decrease of abundance) | Nod2(m.s.) --> MCP-1(h) (increase of abundance) | GM-CSF(m.s.) --> MCP-1(h) (increase of abundance) | AKAP13(h) --> MCP-1(h) (increase of abundance) | IFNgamma(h) --> MCP-1(h) (increase of abundance) | IL-17A(h) --> MCP-1(h) (increase of secretion) | IL-17F(h) --> MCP-1(h) (increase of secretion) | TNF-alpha(m.s.) --> MCP-1(h) (increase of secretion) | IFNbeta(h) --> MCP-1(h) (increase of abundance) | LPS --> MCP-1(h) (decrease of secretion) | adiponectin(h) + MCP-1(h) <==> adiponectin(h):MCP-1(h) (binding) | heparin + MCP-1(h) <==> heparin:MCP-1(h) (binding) | CCL2(h) --> MCP-1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
24 | Pyrrolidone carboxylic acid. | Swiss-Prot 53.0 | 37 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
There is no record for CCL2 | ||