Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	6532
Name	SLC6A4
Synonymous	5-HTT\|5-HTTLPR\|5HTT\|HTT\|OCD1\|SERT\|SERT1\|hSERT;solute carrier family 6 (neurotransmitter transporter, serotonin), member 4;SLC6A4;solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Definition	5-hydroxytryptamine transporter\|5HT transporter\|Na+/Cl- dependent serotonin transporter\|sodium-dependent serotonin transporter
Position	17q11.2
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr17:28521337-28563020	chr17:28523726-28523726	rs7224199	Single_Nucleotides\|eQTL\|SSH2, Chromatin_Structure\|FAIRE\|Huvec, Chromatin_Structure\|DNase-seq\|Hmvecdblneo, Chromatin_Structure\|DNase-seq\|Huvec, Chromatin_Structure\|DNase-seq\|Hmvecdblad, Chromatin_Structure\|DNase-seq\|Hmvecdlyneo, Chromatin_Structure\|DNase-seq\|Hmveclbl
chr17:28521337-28563020	chr17:28538715-28538715	rs4583306	Single_Nucleotides\|eQTL\|SSH2, Protein_Binding\|ChIP-seq\|IKZF1
chr17:28521337-28563020	chr17:28547210-28547210	rs8076005	Single_Nucleotides\|eQTL\|SSH2, Chromatin_Structure\|DNase-seq\|Huh75, Chromatin_Structure\|DNase-seq\|Hepatocytes, Chromatin_Structure\|DNase-seq\|Huh7, Chromatin_Structure\|FAIRE\|K562, Chromatin_Structure\|DNase-seq\|K562, Chromatin_Structure\|DNase-seq\|Caco2, Chromatin_Structure\|DNase-seq\|Hepg2, Protein_Binding\|ChIP-seq\|HNF4A, Protein_Binding\|ChIP-seq\|HNF4A, Protein_Binding\|ChIP-seq\|ELF1, Protein_Binding\|ChIP-seq\|SP1, Protein_Binding\|ChIP-seq\|ELF1

Regulation From TransFac database
Transcription Factors [Top]
5HTT(h) + PICK1(h) <==> 5HTT(h):PICK1(h) (binding)
SLC6A4(h) --> 5HTT(h) (expression).
SLC6A4(h) --> 5HTT(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
208	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
217	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr17	Promoter: 25586331 - 25588331	Agilent_014791
chr17	Promoter: 25586331 - 25588331	GSE27584

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