| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 6696 |
Name | SPP1 |
Synonymous | BNSP|BSPI|ETA-1|OPN;secreted phosphoprotein 1;SPP1;secreted phosphoprotein 1 |
Definition | SPP1/CALPHA1 fusion|early T-lymphocyte activation 1|nephropontin|osteopontin|osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein|secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)|urinar |
Position | 4q22.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
|
Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
|---|---|---|---|
| chr4:88896819-88904562 | chr4:88898941-88898941 | rs11728697 | Single_Nucleotides|eQTL|AFF1, Motifs|PWM|HMGA2, Protein_Binding|ChIP-seq|RFX3 |
Transcription Factors [Top] |
|
Regulation From TransFac database |
|---|
| SPP1(h) --> OPN-isoform1(h) (expression). |
| IGFBP-5(h) + OPN(h) <==> IGFBP-5(h):OPN(h) (binding) |
| OPN(h) + IGFBP-3(h) <==> OPN(h):IGFBP-3(h) (binding) |
| OPN(h) + IGFBP-2(h) <==> OPN(h):IGFBP-2(h) (binding) |
| Alpha-SGT(h) + OPN(h) <==> Alpha-SGT(h):OPN(h) (binding) |
| OPN(h) + LMP(h) <==> OPN(h):LMP(h) (binding) |
| OPN(h) + NAP(h) <==> OPN(h):NAP(h) (binding) |
| OPN(h) --> OPN-p45(h) + protein remnants (cleavage) |
| OPN(h) --> OPN-p50(h) + protein remnants (cleavage) |
| CD44(h) + OPN(h) <==> CD44(h):OPN(h) (binding) |
| SPP1(h) --> OPN(h) (expression). |
| SPP1(h) --> OPN-isoform2(h) (expression). |
| SPP1(h) --> OPN-isoform3(h) (expression). |
| SPP1(h) --> OPN-isoform4(h) (expression). |
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
|---|---|---|---|
| 24 | Phosphoserine. | Swiss-Prot 53.0 | |
| 26 | Phosphoserine. | Swiss-Prot 53.0 | |
| 27 | Phosphoserine. | Swiss-Prot 53.0 | |
| 62 | Phosphoserine. | Swiss-Prot 53.0 | |
| 63 | Phosphoserine. | Swiss-Prot 53.0 | |
| 66 | Phosphothreonine. | Swiss-Prot 53.0 | |
| 76 | Phosphoserine. | Swiss-Prot 53.0 | |
| 79 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | |
| 81 | Phosphoserine. | Swiss-Prot 53.0 | |
| 99 | Phosphoserine. | Swiss-Prot 53.0 | |
| 102 | Phosphoserine. | Swiss-Prot 53.0 | |
| 105 | Phosphoserine. | Swiss-Prot 53.0 | |
| 106 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | |
| 108 | Phosphoserine. | Swiss-Prot 53.0 | |
| 117 | Phosphoserine. | Swiss-Prot 53.0 | |
| 120 | Phosphoserine. | Swiss-Prot 53.0 | |
| 123 | Phosphoserine. | Swiss-Prot 53.0 | |
| 126 | Phosphoserine. | Swiss-Prot 53.0 | |
| 129 | Phosphoserine. | Swiss-Prot 53.0 | |
| 134 | O-linked (GalNAc...). | Swiss-Prot 53.0 | |
| 138 | O-linked (GalNAc...). | Swiss-Prot 53.0 | |
| 143 | O-linked (GalNAc...). | Swiss-Prot 53.0 | |
| 147 | O-linked (GalNAc...). | Swiss-Prot 53.0 | |
| 152 | O-linked (GalNAc...). | Swiss-Prot 53.0 | |
| 185 | Phosphothreonine. | Swiss-Prot 53.0 | |
| 191 | Phosphoserine. | Swiss-Prot 53.0 | |
| 195 | Phosphoserine. | Swiss-Prot 53.0 | |
| 215 | Phosphoserine. | Swiss-Prot 53.0 | |
| 219 | Phosphoserine. | Swiss-Prot 53.0 | |
| 224 | Phosphoserine. | Swiss-Prot 53.0 | |
| 228 | Phosphoserine. | Swiss-Prot 53.0 | |
| 234 | Phosphoserine. | Swiss-Prot 53.0 | |
| 254 | Phosphoserine. | Swiss-Prot 53.0 | |
| 263 | Phosphoserine. | Swiss-Prot 53.0 | |
| 267 | Phosphoserine. | Swiss-Prot 53.0 | |
| 275 | Phosphoserine. | Swiss-Prot 53.0 | |
| 280 | Phosphoserine. | Swiss-Prot 53.0 | |
| 303 | Phosphoserine. | Swiss-Prot 53.0 | |
| 308 | Phosphoserine. | Swiss-Prot 53.0 | |
| 310 | Phosphoserine. | Swiss-Prot 53.0 | |
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr4 |
Promoter: 89114326 - 89116326 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 89114326 - 89116326 | GoldenGate_Methylation_Cancer_Panel_I |
chr4 |
Promoter: 89114326 - 89116326 | GoldenGate_Methylation_Cancer_Panel_I |