Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	6863
Name	TAC1
Synonymous	Hs.2563\|NK2\|NKNA\|NPK\|TAC2;tachykinin, precursor 1;TAC1;tachykinin, precursor 1
Definition	PPT\|neurokinin 1\|neurokinin 2\|neurokinin A\|neurokinin alpha\|neuromedin L\|neuropeptide K\|neuropeptide gamma\|preprotachykinin\|protachykinin-1\|substance K\|substance P\|tachykinin 2\|tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2,
Position	7q21-q22
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr7:97361220-97369784	chr7:97369496-97369496	rs12534885	Single_Nucleotides\|eQTL\|ASNS, Motifs\|PWM\|Meis1, Motifs\|PWM\|Mrg1, Motifs\|PWM\|Mrg2, Motifs\|PWM\|Pknox1, Motifs\|PWM\|Pknox2, Motifs\|PWM\|Tgif2, Protein_Binding\|ChIP-seq\|AR

Regulation From TransFac database
Transcription Factors [Top]
TAC1(h) --> TAC1(h) (expression).
hsa-miR-130a --/ TAC1(h) (translational repression).
hsa-miR-206 --/ TAC1(h) (translational repression).
TAC1(h) --> tachykinin1-beta(h) (expression).
TAC1(h) --> tachykinin1-alpha(h) (expression).
TAC1(h) --> tachykinin1-gamma(h) (expression).
TAC1(h) --> tachykinin1-delta(h) (expression).
TAC1(h) --> tachykinin1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
68	Methionine amide (G-69 provides amidegroup).		Swiss-Prot 53.0
107	Methionine amide (G-108 provides amidegroup).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr7	Promoter: 97197811 - 97199811	Agilent_014791
chr7	Promoter: 97197811 - 97199811	GSE27584
chr7	Promoter: 97197811 - 97199811	GSE27584
chr7	Promoter: 97197811 - 97199811	GSE27584
chr7	Promoter: 97197811 - 97199811	GSE27584
chr7	Promoter: 97197811 - 97199811	Agilent_014791_44K
chr7	Promoter: 97197811 - 97199811	PMID:16952549
chr7	Promoter: 97197811 - 97199811	PMID:16952549
chr7	Promoter: 97197811 - 97199811	PMID:16952549
chr7	Promoter: 97197811 - 97199811	PMID:16952549

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