| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 7124 |
Name | TNF |
Synonymous | DIF|TNF-alpha|TNFA|TNFSF2;tumor necrosis factor;TNF;tumor necrosis factor |
Definition | APC1 protein|TNF, macrophage-derived|TNF, monocyte-derived|TNF-a|cachectin|tumor necrosis factor ligand superfamily member 2|tumor necrosis factor-alpha |
Position | 6p21.3 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for TNF | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
TNF-alpha(h) --> Trx1(h) (activation; translocation) | TNF-alpha(h) --> S-SMase(m) (activation) | TNF-alpha(h) --> A-SMase(h) (activation) | TNF-alpha(h) --> N-SMase(h) (activation) | TNF-alpha(h) --> IKK-alpha(h){pY} (increase of phosphorylation) | TNF-alpha(h) --> IKK-beta(h){pY} (increase of phosphorylation) | TNF-alpha(h) --> A4GALT(h) (increase of abundance) | TNF-alpha(h) --> TRADD(h) (regulation of localization) | TNF-alpha(h) --> TRAF2(h) (binding) | TNF-alpha(h) --> TRADD(h) (binding) | TNF-alpha(h) --> TNFR1(h) (binding) | TNF-alpha(h) --> IkappaB-alpha(h){pS32} (increase of phosphorylation) | TNF-alpha(h) --> TAB1(h){pS423}{pT431} (increase of phosphorylation) | TNF-alpha(h) --> trip6(h):RIP2(h) (increase of binding) | TNF-alpha(h) --> Erbin(h) (increase of abundance) | TNF-alpha(h) --> DAPK(h){pS308} (decrease of phosphorylation) | TNF-alpha(h) --> XAF1(h) (increase of abundance) | TNF-alpha(h) --> XIAP(h) (increase of cleavage) | TNF-alpha(h) --> JNK(m){p} (increase of phosphorylation) | TNF-alpha(h) --> ERK1(m){p} (increase of phosphorylation) | TNF-alpha(h) --> ERK2(m){p} (increase of phosphorylation) | TNF-alpha(h) --> IER3IP1(h) (transactivation) | IL-17A(h) --> TNF-alpha(h) (activation) | TNF(h) --> TNF-alpha(h) (expression). | relaxin-2(h) --> TNF-alpha(h) (decrease of secretion) | CD3(h) --> TNF-alpha(h) (increase of secretion) | HCV-E2 protein-1A(HCV1A) --> TNF-alpha(h) (increase of abundance) | CD81(h) --> TNF-alpha(h) (increase of abundance) | Hck(h) --> TNF-alpha(h) (increase of abundance) | FcgammaRI alpha(h) --> TNF-alpha(h) (decrease of secretion) | FcgammaRIIA(h) --> TNF-alpha(h) (decrease of secretion) | FCgammaRIIIA(h) --> TNF-alpha(h) (decrease of secretion) | LPG(LEIMA) --> TNF-alpha(h) (increase of abundance) | CD154(h) --> TNF-alpha(h) (increase of abundance) | SLAM(h) --/ TNF-alpha(h) (decrease of abundance) | IFNgamma(h) --> TNF-alpha(h) (increase of secretion) | MyD88(m.s.) --/ TNF-alpha(h) (decrease of abundance) | MAL(m.s.) --/ TNF-alpha(h) (decrease of abundance) | H2O2 --> TNF-alpha(h) (increase of secretion) | LPS --> TNF-alpha(h) (increase of secretion) | LPS --> TNF-alpha(h) (decrease of secretion) | 3pRNA --> TNF-alpha(h) (increase of secretion) | bst2(h) --> TNF-alpha(h) (decrease of secretion) | ssRNA --> TNF-alpha(h) (increase of secretion) | ZAP-70(h) --> TNF-alpha(h) (increase of secretion) | LPS(ECO) --> TNF-alpha(h) (increase of secretion) | TNF-alpha(h) --> AKT(h){p} (decrease of phosphorylation) | TNF-alpha(h) --/ IkappaB-alpha(h) (decrease of abundance) | TNF-alpha(h) --/ NF-kappaB1(h) (decrease of abundance) | TNF-alpha(h) --> NF-kappaB1-p50(h) (increase of abundance) | TNF-alpha(h) --> Cdk2(h):p21Cip1(h) (decrease of binding) | TNF-alpha(h) --> p21Cip1(h){pS146} (increase of phosphorylation) | TNF-alpha(h) --> p38(h){p} (increase of phosphorylation) | TNF-alpha(h) --/ mcm2(h) (decrease of abundance) | TNF-alpha(h) --> p53(h):CBP(h) (decrease of binding) | TNF-alpha(h) --> RelA-p65(h):CBP(h) (increase of binding) | TNF-alpha(h) --> CBP(m):CREB1(m) (increase of binding) | TNF-alpha(h) --> Caspase-3-p17(h) (increase of processing) | TNF-alpha(h) --> Caspase-8-p44(h) (increase of processing) | TNF-alpha(h) --> Caspase-8-p20(h) (increase of processing) | TNF-alpha(h) --> IkappaB-alpha(h) (increase of cleavage) | TNF-alpha(h) --> c-FLIP-S(h) (increase of abundance) | TNF-alpha(h) --> Tbxas1(r) (transactivation) | TNF-alpha(h) --> RelA-p65(h) (increase of phosphorylation) | TNF-alpha(h) --> RelA-p65(m) (increase of phosphorylation) | TNF-alpha(h) --> p70S6K1-alpha2(h){pT389} (increase of phosphorylation) | TNF-alpha(h) --> 4E-BP1(h){pS65} (increase of phosphorylation) | TNF-alpha(h) --> p70S6K1-alpha2(m){pT389} (increase of phosphorylation) | TNF-alpha(h) --> hamartin(h){ub} (increase of phosphorylation) | TNF-alpha(h) --> tuberin(h){ub} (increase of phosphorylation) | TNF-alpha(h) --> hamartin(h):tuberin(h) (decrease of binding) | TNF-alpha(h) --> VEGFA(h) (transactivation) | TNF-alpha(h) --> RelA-p65(h){pS536} (increase of phosphorylation) | TNF-alpha(h) --> Il6(m) (transactivation) | TNF-alpha(h) --> Nos2(m) (transactivation) | TNF-alpha(h) --> BIRC3(h) (transactivation) | TNF-alpha(h) --> CD11B(h) (increase of abundance) | TNF-alpha(h) --> beta2-integrin(h) (increase of abundance) | TNF-alpha(h) --> Hck(h){p} (increase of phosphorylation) | TNF-alpha(h) --> AKT(h){p} (increase of phosphorylation) | TNF-alpha(h) --> RelA-p65(h) (increase of abundance) | TNF-alpha(h) --> ERK1(h){p} (increase of phosphorylation) | TNF-alpha(h) --> ERK2(h){p} (increase of phosphorylation) | TNF-alpha(h) --> IkappaB-alpha(m.s.){p} (increase of phosphorylation) | TNF-alpha(h) --> p38alpha(h){p} (increase of phosphorylation) | TNF-alpha(h) --> Adam8(m) (transactivation) | TNF-alpha(h) --> NF-kappaB2-p100(h) (increase of abundance) | TNF-alpha(h) --> NUAK2(h) (transactivation) | TNF-alpha(h) --> SNARK(h) (increase of abundance) | TNF-alpha(h) --> IL8(h) (transactivation) | TNF-alpha(h) --> TNIP1(h) (transactivation) | TNF-alpha(h) --> RelA-p65(h){pS276} (increase of phosphorylation) | TNF-alpha(h) --> p300(m.s.):RelA-p65(h) (increase of binding) | TNF-alpha(h) --> ErbB1(h){pY} (increase of phosphorylation) | TNF-alpha(h) --> ERK(h){p} (increase of phosphorylation) | TNF-alpha(h) --> TNFR1(h):TRAF2(h) (increase of binding) | TNF-alpha(h) --> CCL2(h) (transactivation) | TNF-alpha(h) --> CCL5(h) (transactivation) | TNF-alpha(h) --> CXCL10(h) (transactivation) | TNF-alpha(h) --> IkappaB-alpha(m){pS32}{pS36} (increase of phosphorylation) | TNF-alpha(h) --> TNFR1(h):TRADD(h):RIP(h):TRAF2(h) (increase of binding) | TNF-alpha(h) --> RIP(h){ub}n:TNFR1(h):TRADD(h):TRAF2(h) (increase of ubiquitination) | TNF-alpha(h) --> IKK(m){p} (increase of phosphorylation) | TNF-alpha(h) --> p38(m){p} (increase of phosphorylation) | TNF-alpha(h) --> JNK(m){p} (increase of phosphorylation) | TNF-alpha(h) --> c-Jun(m){pS63} (increase of phosphorylation) | TNF-alpha(h) --> RelA-p65(m){p} (increase of phosphorylation) | TNF-alpha(h) --> RelA-p65(m){aceK310} (increase of acetylation) | TNF-alpha(h) --> MMP9(h) (transactivation) | TNF-alpha(h) --> gelatinase B(h) (increase of abundance) | TNF-alpha(h) --> Src(h){pY} (increase of phosphorylation) | TNF-alpha(h) --> EGFR(h){pY} (increase of phosphorylation) | TNF-alpha(h) --> PDGFR(h){pY} (increase of phosphorylation) | TNF-alpha(h) --> Src(h):EGFR(h){pY} (increase of binding) | TNF-alpha(h) --> AKT(h):CBP(h) (increase of binding) | TNF-alpha(h) --> CBP(h):RelA-p65(h) (increase of binding) | TNF-alpha(h) --> PKR(m){p} (increase of phosphorylation) | TNF-alpha(h) --> IkappaB-alpha(m){p} (increase of phosphorylation) | TNF-alpha(h) --> AKT-1(m){p} (increase of phosphorylation) | TNF-alpha(h) --> cyclinD1(m) (increase of abundance) | TNF-alpha(h) --> c-Myc(m) (increase of abundance) | TNF-alpha(h) --> gelatinase B(m) (increase of abundance) | TNF-alpha(h) --> survivin(m) (increase of abundance) | TNF-alpha(h) --> XIAP(m) (increase of abundance) | TNF-alpha(h) --> cIAP-2(m) (increase of abundance) | TNF-alpha(h) --> Bcl-xL(m) (increase of abundance) | TNF-alpha(h) --> A1(m) (increase of abundance) | TNF-alpha(h) --> c-FLIP(m) (increase of abundance) | TNF-alpha(h) --> AKT-1(h){pS473} (increase of phosphorylation) | TNF-alpha(h) --> JNK1(h){p} (increase of phosphorylation) | TNF-alpha(h) --> JNK(h){p} (increase of phosphorylation) | TNF-alpha(h) --> JNK1beta1(h){p} (increase of phosphorylation) | TNF-alpha(h) --> Bim(h){p} (increase of phosphorylation) | TNF-alpha(h) --> PARP-p29(h) (increase of cleavage) | TNF-alpha(h) --> Caspase-8-p43(h) (increase of cleavage) | TNF-alpha(h) --> Caspase-8-p41(h) (increase of cleavage) | TNF-alpha(h) --> Bid-p15(h) (increase of cleavage) | TNF-alpha(h) --> icam1(h) (increase of abundance) | TNF-alpha(h) --> vcam1(h) (increase of abundance) | TNF-alpha(h) --> lipocalin2(m) (increase of abundance) | TNF-alpha(h) --> PKCdelta(h){pT507} (increase of phosphorylation) | TNF-alpha(h) --> IP-10(h) (increase of secretion) | TNF-alpha(h) --> IkappaB-alpha(h){p} (increase of phosphorylation) | TNF-alpha(h) --> VEGF-A(h) (increase of secretion) | TNF-alpha(h) --> TGFB2(h) (transactivation) | TNF-alpha(h) --> TGFB1(h) (transactivation) | TNF-alpha(h) --> TGFbeta1(h) (increase of secretion) | TNF-alpha(h) --> TGFbeta2(h) (increase of secretion) | TNF-alpha(h) --> irf1(h) (increase of abundance) | TNF-alpha(h) --> IL-11(h) (increase of secretion) | TNF-alpha(h) --> STAT1(h){pS727} (increase of phosphorylation) | TNF-alpha(h) --> Lcn2(m) (transactivation) | TNF-alpha(h) --> DEFB4(h) (transactivation) | TNF-alpha(h) --> CCL20(h) (transactivation) | TNF-alpha(h) --/ IkappaB-alpha(m) (decrease of abundance) | TNF-alpha(h) --> IL-6(m) (increase of secretion). | TNF-alpha(h) --> c-Jun(m.s.){p} (increase of phosphorylation) | TNF-alpha(h) --> IL6(h) (transactivation) | TNF-alpha(h) --> IKK-beta(h){p} (increase of phosphorylation) | TNF-alpha(h) --> RelA-p65(h){ace} (increase of acetylation) | TNF-alpha(h) --> RIP(m){ub}n (increase of ubiquitination) | TNF-alpha(h) --> A20(m.s.):RIP(m.s.) (increase of binding) | TNF-alpha(h) --> OTUD7B(h) (transactivation) | TNF-alpha(h) --> Cezanne(h) (increase of abundance) | TNF-alpha(h) + Cezanne(m.s.) <==> TNF-alpha(h):Cezanne(m.s.) (binding) | TNF-alpha(h) --> IKK-gamma(m){ub}n (increase of ubiquitination) | TNF-alpha(h) --> IL-8(h) (increase of abundance) | TNF-alpha(h) --/ L-dopachrome tautomerase(h) (decrease of abundance) | TNF-alpha(h) --/ tyrosinase(h) (decrease of abundance) | TNF-alpha(h) --/ Tyrp1(h) (decrease of abundance) | TNF-alpha(h) --> stromelysin1(pg) (increase of abundance) | TNF-alpha(h) --> gelatinase B(pg) (increase of abundance) | TNF-alpha(h) --> JNK1(pg){pT183}{pY185} (increase of phosphorylation) | TNF-alpha(h) --> JNK2(pg){pT183}{pY185} (increase of phosphorylation) | TNF-alpha(h) --> MKK4(pg){pS257}{pT261} (increase of phosphorylation) | TNF-alpha(h) --> c-Jun(pg){pS73} (increase of phosphorylation) | TNF-alpha(h) --> ATF-2(pg){pT} (increase of phosphorylation) | TNF(h) --> TNF-alpha(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | Phosphoserine (by CK1). | Swiss-Prot 53.0 | 19 | N6-myristoyl lysine. | Swiss-Prot 53.0 | 20 | N6-myristoyl lysine. | Swiss-Prot 53.0 | 80 | O-linked | Takakura-Yamamoto R., Yamamoto S., Fukuda S. and Kurimoto M. (1996)Eur. J. Biochem., 235, 431-437. Medline: 96202967; | OGlycBase6.0 |
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Methylation Profile [Top] | ||
There is no record for TNF | ||