Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

960

Name

CD44

Synonymous

CDW44|CSPG8|ECMR-III|HCELL|HUTCH-I|IN|LHR|MC56|MDU2|MDU3|MIC4|Pgp1;CD44 molecule (Indian blood group);CD44;CD44 molecule (Indian blood group)

Definition

CD44 antigen|GP90 lymphocyte homing/adhesion receptor|Hermes antigen|cell surface glycoprotein CD44|chondroitin sulfate proteoglycan 8|epican|extracellular matrix receptor III|hematopoietic cell E- and L-selectin ligand|heparan sulfate proteoglycan|homing

Position

11p13

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for CD44

Transcription Factors   [Top]

Regulation From TransFac database

CD44(h) --> CD44-CTF(h) (processing)
IQGAP1(h) + CD44(h) <==> IQGAP1(h):CD44(h) (binding)
CD44(h) + ErbB2(h){p} <==> CD44(h):ErbB2(h){p} (binding)
p85(h) + p110alpha(h) + Hsp50(h) + Hsp90(h) + ezrin(h) + CD44(h) + ErbB2(h){p} <==> p85(h):p110alpha(h):Hsp50(h):Hsp90(h):ezrin(h):CD44(h):ErbB2(h){p} (binding)
p110alpha(h) + Hsp50(h) + ezrin(h) + CD44(h) + ErbB2(h){p} <==> p110alpha(h):Hsp50(h):ezrin(h):CD44(h):ErbB2(h){p} (binding)
Hsp50(h) + ezrin(h) + CD44(h) + ErbB2(h){p} <==> Hsp50(h):ezrin(h):CD44(h):ErbB2(h){p} (binding)
Vav-2(h) + CD44(h) <==> Vav-2(h):CD44(h) (binding)
Vav-2(h) + CD44(h) <==> Vav-2(h):CD44(h) (binding)
Vav-2(h) + Grb-2(h) + CD44(h) + ErbB2(h) <==> Vav-2(h):Grb-2(h):CD44(h):ErbB2(h) (binding)
Grb-2(m.s.) + Vav-2(h) + CD44(h) + ErbB2(h) <==> Grb-2(m.s.):Vav-2(h):CD44(h):ErbB2(h) (binding)
ErbB1(h) + CD44(h) <==> ErbB1(h):CD44(h) (binding)
ErbB1(h) + ErbB2(h) + CD44(h) <==> ErbB1(h):ErbB2(h):CD44(h) (binding)
CD44(h) + nanog(h) <==> CD44(h):nanog(h) (binding)
MDR-1(h) + CD44(h) + ANK2(h) <==> MDR-1(h):CD44(h):ANK2(h) (binding)
CD44(h) + Merlin(h) <==> CD44(h):Merlin(h) (binding)
CD44(h) + OPN(h) <==> CD44(h):OPN(h) (binding)
CD44(h) --> CD44(h) (expression).
CD44(h) --> CD44-isoform2(h) (expression).
CD44(h) --> CD44-isoform1(h) (expression).
CD44(h) --> CD44-isoform3(h) (expression).
CD44(h) --> CD44-isoform4(h) (expression).
CD44(h) --> CD44-isoform5(h) (expression).
CD44(h) --> CD44-isoform6(h) (expression).
CD44(h) --> CD44-isoform7(h) (expression).
CD44(h) --> CD44-isoform8(h) (expression).
CD44(h) --> CD44-isoform9(h) (expression).
CD44(h) --> CD44-isoform10(h) (expression).
CD44(h) --> CD44-isoform11(h) (expression).
CD44(h) --> CD44-isoform12(h) (expression).
CD44(h) --> CD44-isoform13(h) (expression).
CD44(h) --> CD44-isoform14(h) (expression).
CD44(h) --> CD44-isoform15(h) (expression).
CD44(h) --> CD44-isoform16(h) (expression).
CD44(h) --> CD44-isoform17(h) (expression).
CD44(h) --> CD44(h) (expression).
hsa-miR-328 --/ CD44(h) (translational repression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

21Pyrrolidone carboxylic acid (Probable).Swiss-Prot 53.0
25N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
57N-linked (GlcNAc...).Swiss-Prot 53.0
100N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
110N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
120N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
350N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
548N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
599N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
636N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
672Phosphoserine; by PKC.Swiss-Prot 53.0
686Phosphoserine.Swiss-Prot 53.0
697Phosphoserine.Swiss-Prot 53.0
706Phosphoserine.Swiss-Prot 53.0
720Phosphothreonine.Swiss-Prot 53.0
686Phosphoserine17081983Phospho.ELM 6.0
697Phosphoserine17081983Phospho.ELM 6.0
720Phosphothreonine17081983Phospho.ELM 6.0
672Phosphoserine (PKC alpha)12032545Phospho.ELM 6.0
706Phosphoserine12032545;17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr11

 Promoter: 35115493 - 35117493Agilent_014791

chr11

 Promoter: 35115493 - 35117493GoldenGate_Methylation_Cancer_Panel_I

chr11

 Promoter: 35115493 - 35117493GoldenGate_Methylation_Cancer_Panel_I

chr11

 Promoter: 35115493 - 35117493GoldenGate_Methylation_Cancer_Panel_I

chr11

 Promoter: 35115493 - 35117493GoldenGate_Methylation_Cancer_Panel_I

chr11

 Promoter: 35115493 - 35117493GoldenGate_Methylation_Cancer_Panel_I

chr11

 Promoter: 35115493 - 35117493GSE27584

chr11

 Promoter: 35115493 - 35117493GSE27584

chr11

 Promoter: 35115493 - 35117493GSE27584

chr11

 Promoter: 35115493 - 35117493GSE27584

chr11

 Promoter: 35115493 - 35117493GSE27584

chr11

 Promoter: 35115493 - 35117493Agilent_014791_44K

chr11

 Promoter: 35115493 - 35117493PMID:15036650

chr11

 Promoter: 35115493 - 35117493PMID:15036650

chr11

 Promoter: 35115493 - 35117493PMID:15036650

chr11

 Promoter: 35115493 - 35117493PMID:15036650

chr11

 Promoter: 35115493 - 35117493PMID:15036650

chr11

 Promoter: 35115493 - 35117493PMID:12692786

chr11

 Promoter: 35115493 - 35117493PMID:12692786

chr11

 Promoter: 35115493 - 35117493PMID:12692786

chr11

 Promoter: 35115493 - 35117493PMID:12692786

chr11

 Promoter: 35115493 - 35117493PMID:12692786

chr11

 Promoter: 35115493 - 35117493PMID:15289848

chr11

 Promoter: 35115493 - 35117493PMID:15289848

chr11

 Promoter: 35115493 - 35117493PMID:15289848

chr11

 Promoter: 35115493 - 35117493PMID:15289848

chr11

 Promoter: 35115493 - 35117493PMID:15289848

chr11

 Promoter: 35115493 - 35117493PMID:16478744

chr11

 Promoter: 35115493 - 35117493PMID:16478744

chr11

 Promoter: 35115493 - 35117493PMID:16478744

chr11

 Promoter: 35115493 - 35117493PMID:16478744

chr11

 Promoter: 35115493 - 35117493PMID:16478744

chr11

 Promoter: 35115493 - 35117493PMID:10344738

chr11

 Promoter: 35115493 - 35117493PMID:10344738

chr11

 Promoter: 35115493 - 35117493PMID:10344738

chr11

 Promoter: 35115493 - 35117493PMID:10344738

chr11

 Promoter: 35115493 - 35117493PMID:10344738

chr11

 Promoter: 35115493 - 35117493PMID:17139617

chr11

 Promoter: 35115493 - 35117493PMID:17139617

chr11

 Promoter: 35115493 - 35117493PMID:17139617

chr11

 Promoter: 35115493 - 35117493PMID:17139617

chr11

 Promoter: 35115493 - 35117493PMID:17139617

chr11

 Promoter: 35115493 - 35117493PMID:11582589

chr11

 Promoter: 35115493 - 35117493PMID:11582589

chr11

 Promoter: 35115493 - 35117493PMID:11582589

chr11

 Promoter: 35115493 - 35117493PMID:11582589

chr11

 Promoter: 35115493 - 35117493PMID:11582589

chr11

 Promoter: 35115493 - 35117493PMID:12782013

chr11

 Promoter: 35115493 - 35117493PMID:12782013

chr11

 Promoter: 35115493 - 35117493PMID:12782013

chr11

 Promoter: 35115493 - 35117493PMID:12782013

chr11

 Promoter: 35115493 - 35117493PMID:12782013

chr11

 Promoter: 35115493 - 35117493PMID:12508241

chr11

 Promoter: 35115493 - 35117493PMID:12508241

chr11

 Promoter: 35115493 - 35117493PMID:12508241

chr11

 Promoter: 35115493 - 35117493PMID:12508241

chr11

 Promoter: 35115493 - 35117493PMID:12508241

')