Gene Page: CHAF1A

Summary ?
GeneID10036
SymbolCHAF1A
SynonymsCAF-1|CAF1|CAF1B|CAF1P150|P150
Descriptionchromatin assembly factor 1 subunit A
ReferenceMIM:601246|HGNC:HGNC:1910|Ensembl:ENSG00000167670|HPRD:03148|Vega:OTTHUMG00000181922
Gene typeprotein-coding
Map location19p13.3
Pascal p-value0.218
Fetal beta0.763
DMG1 (# studies)
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0064 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg04346879194402785CHAF1A1.325E-4-0.2140.03DMG:Wockner_2014
ch.19.239668R194434073CHAF1A2.035E-4-0.5990.035DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12462529194359525CHAF1AENSG00000167670.117.11E-70.01-43134gtex_brain_ba24
rs7769194360543CHAF1AENSG00000167670.119.539E-70.01-42116gtex_brain_ba24
rs11670201194364777CHAF1AENSG00000167670.111.026E-60.01-37882gtex_brain_ba24
rs11666453194368797CHAF1AENSG00000167670.119.384E-70.01-33862gtex_brain_ba24
rs56033249194369447CHAF1AENSG00000167670.119.347E-70.01-33212gtex_brain_ba24
rs11667543194374850CHAF1AENSG00000167670.118.805E-70.01-27809gtex_brain_ba24
rs11085073194375162CHAF1AENSG00000167670.119.446E-70.01-27497gtex_brain_ba24
rs62129349194385659CHAF1AENSG00000167670.114.372E-70.01-17000gtex_brain_ba24
rs11085074194386352CHAF1AENSG00000167670.114.368E-70.01-16307gtex_brain_ba24
rs55637375194386845CHAF1AENSG00000167670.114.366E-70.01-15814gtex_brain_ba24
rs62129351194387125CHAF1AENSG00000167670.116.666E-70.01-15534gtex_brain_ba24
rs9973266194392715CHAF1AENSG00000167670.115.636E-70.01-9944gtex_brain_ba24
rs62129353194395763CHAF1AENSG00000167670.114.619E-70.01-6896gtex_brain_ba24
rs62129354194396505CHAF1AENSG00000167670.114.441E-70.01-6154gtex_brain_ba24
rs62129355194397034CHAF1AENSG00000167670.114.687E-70.01-5625gtex_brain_ba24
rs62129356194400314CHAF1AENSG00000167670.113.34E-70.01-2345gtex_brain_ba24
rs2230636194409756CHAF1AENSG00000167670.111.114E-70.017097gtex_brain_ba24
rs56411083194410646CHAF1AENSG00000167670.111.062E-70.017987gtex_brain_ba24
rs34080966194417845CHAF1AENSG00000167670.118.978E-80.0115186gtex_brain_ba24
rs56227586194418515CHAF1AENSG00000167670.119.793E-80.0115856gtex_brain_ba24
rs56272533194420042CHAF1AENSG00000167670.111.004E-70.0117383gtex_brain_ba24
rs56088814194422178CHAF1AENSG00000167670.111.585E-70.0119519gtex_brain_ba24
rs11668886194423419CHAF1AENSG00000167670.115.083E-70.0120760gtex_brain_ba24
rs59488897194425236CHAF1AENSG00000167670.118.978E-80.0122577gtex_brain_ba24
rs55660045194425305CHAF1AENSG00000167670.118.978E-80.0122646gtex_brain_ba24
rs62130978194429007CHAF1AENSG00000167670.119.793E-80.0126348gtex_brain_ba24
rs62130979194432444CHAF1AENSG00000167670.118.858E-80.0129785gtex_brain_ba24
rs12459919194434503CHAF1AENSG00000167670.118.978E-80.0131844gtex_brain_ba24
rs11666856194437450CHAF1AENSG00000167670.113.259E-70.0134791gtex_brain_ba24
rs11669263194441407CHAF1AENSG00000167670.118.978E-80.0138748gtex_brain_ba24
rs56156435194444654CHAF1AENSG00000167670.113.568E-70.0141995gtex_brain_ba24
rs760369194449287CHAF1AENSG00000167670.119.908E-80.0146628gtex_brain_ba24
rs1127888194454083CHAF1AENSG00000167670.111.592E-70.0151424gtex_brain_ba24
rs72990643194454736CHAF1AENSG00000167670.111.586E-70.0152077gtex_brain_ba24
rs12459922194455862CHAF1AENSG00000167670.111.59E-70.0153203gtex_brain_ba24
rs56153949194457518CHAF1AENSG00000167670.114.703E-80.0154859gtex_brain_ba24
rs11670503194458063CHAF1AENSG00000167670.112.198E-70.0155404gtex_brain_ba24
rs12462529194359525CHAF1AENSG00000167670.111.93E-70-43134gtex_brain_putamen_basal
rs7769194360543CHAF1AENSG00000167670.113.706E-80-42116gtex_brain_putamen_basal
rs62129346194363289CHAF1AENSG00000167670.113.21E-100-39370gtex_brain_putamen_basal
rs11670201194364777CHAF1AENSG00000167670.113.732E-80-37882gtex_brain_putamen_basal
rs732716194366219CHAF1AENSG00000167670.111.295E-90-36440gtex_brain_putamen_basal
rs11085072194368142CHAF1AENSG00000167670.112.201E-70-34517gtex_brain_putamen_basal
rs11666453194368797CHAF1AENSG00000167670.113.634E-80-33862gtex_brain_putamen_basal
rs56033249194369447CHAF1AENSG00000167670.113.571E-80-33212gtex_brain_putamen_basal
rs11667543194374850CHAF1AENSG00000167670.113.063E-80-27809gtex_brain_putamen_basal
rs11085073194375162CHAF1AENSG00000167670.113.026E-80-27497gtex_brain_putamen_basal
rs62129349194385659CHAF1AENSG00000167670.118.867E-110-17000gtex_brain_putamen_basal
rs11085074194386352CHAF1AENSG00000167670.118.697E-110-16307gtex_brain_putamen_basal
rs55637375194386845CHAF1AENSG00000167670.118.576E-110-15814gtex_brain_putamen_basal
rs62129351194387125CHAF1AENSG00000167670.111.226E-80-15534gtex_brain_putamen_basal
rs9973266194392715CHAF1AENSG00000167670.111.16E-80-9944gtex_brain_putamen_basal
rs5826842194393294CHAF1AENSG00000167670.112.983E-100-9365gtex_brain_putamen_basal
rs62129353194395763CHAF1AENSG00000167670.117.121E-90-6896gtex_brain_putamen_basal
rs62129354194396505CHAF1AENSG00000167670.116.494E-90-6154gtex_brain_putamen_basal
rs62129355194397034CHAF1AENSG00000167670.114.58E-110-5625gtex_brain_putamen_basal
rs62129356194400314CHAF1AENSG00000167670.111.838E-90-2345gtex_brain_putamen_basal
rs200677191194402659CHAF1AENSG00000167670.117.349E-1000gtex_brain_putamen_basal
rs2230636194409756CHAF1AENSG00000167670.111.197E-907097gtex_brain_putamen_basal
rs56411083194410646CHAF1AENSG00000167670.116.103E-1007987gtex_brain_putamen_basal
rs34080966194417845CHAF1AENSG00000167670.111.034E-9015186gtex_brain_putamen_basal
rs56227586194418515CHAF1AENSG00000167670.115.537E-10015856gtex_brain_putamen_basal
rs56272533194420042CHAF1AENSG00000167670.111.135E-9017383gtex_brain_putamen_basal
rs56088814194422178CHAF1AENSG00000167670.116.092E-10019519gtex_brain_putamen_basal
rs11668886194423419CHAF1AENSG00000167670.119.97E-10020760gtex_brain_putamen_basal
rs59488897194425236CHAF1AENSG00000167670.111.034E-9022577gtex_brain_putamen_basal
rs55660045194425305CHAF1AENSG00000167670.111.034E-9022646gtex_brain_putamen_basal
rs62130978194429007CHAF1AENSG00000167670.111.03E-9026348gtex_brain_putamen_basal
rs62130979194432444CHAF1AENSG00000167670.115.601E-10029785gtex_brain_putamen_basal
rs12459919194434503CHAF1AENSG00000167670.111.034E-9031844gtex_brain_putamen_basal
rs11666856194437450CHAF1AENSG00000167670.111.422E-11034791gtex_brain_putamen_basal
rs11669263194441407CHAF1AENSG00000167670.111.034E-9038748gtex_brain_putamen_basal
rs56156435194444654CHAF1AENSG00000167670.112.381E-11041995gtex_brain_putamen_basal
rs78869060194444742CHAF1AENSG00000167670.115.083E-11042083gtex_brain_putamen_basal
rs760369194449287CHAF1AENSG00000167670.117.253E-12046628gtex_brain_putamen_basal
rs1127888194454083CHAF1AENSG00000167670.111.417E-11051424gtex_brain_putamen_basal
rs72990643194454736CHAF1AENSG00000167670.111.418E-11052077gtex_brain_putamen_basal
rs12459922194455862CHAF1AENSG00000167670.111.414E-11053203gtex_brain_putamen_basal
rs56153949194457518CHAF1AENSG00000167670.111.134E-9054859gtex_brain_putamen_basal
rs11670503194458063CHAF1AENSG00000167670.111.475E-11055404gtex_brain_putamen_basal
rs143191932194459785CHAF1AENSG00000167670.116.021E-7057126gtex_brain_putamen_basal
rs149060351194460005CHAF1AENSG00000167670.117.108E-7057346gtex_brain_putamen_basal
rs11669260194460272CHAF1AENSG00000167670.118.009E-7057613gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingTAS7600578 
GO:0051082unfolded protein bindingTAS7600578 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006461protein complex assemblyTAS7600578 
GO:0006335DNA replication-dependent nucleosome assemblyTAS7600578 
GO:0006281DNA repairIEA-
GO:0006260DNA replicationIEA-
GO:0007049cell cycleIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005678chromatin assembly complexTAS7600578 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASF1ACGI-98 | CIA | DKFZp547E2110 | HSPC146ASF1 anti-silencing function 1 homolog A (S. cerevisiae)Affinity Capture-Western
Reconstituted Complex		BioGRID11897662 
ASF1BCIA-II | FLJ10604ASF1 anti-silencing function 1 homolog B (S. cerevisiae)Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex		BioGRID11897662 |17353931 
BAZ1BWBSCR10 | WBSCR9 | WSTFbromodomain adjacent to zinc finger domain, 1B-HPRD12837248 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeAffinity Capture-Western
Far Western
Two-hybrid		BioGRID15143166 
CBX1CBX | HP1-BETA | HP1Hs-beta | HP1Hsbeta | M31 | MOD1 | p25betachromobox homolog 1 (HP1 beta homolog Drosophila )-HPRD10549285 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)-HPRD10549285 |10938122 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID10938122 |12697822 
CHAF1BCAF-1 | CAF-IP60 | CAF1 | CAF1A | CAF1P60 | MPHOSPH7 | MPP7chromatin assembly factor 1, subunit B (p60)-HPRD,BioGRID9614144 
HIST1H3EH3.1 | H3/d | H3FDhistone cluster 1, H3eCAF-1 p150 interacts with H3.1. This interaction was modeled on a demonstrated interaction between human CAF-1 p150 and H3.1 from an unspecified species.BIND15664198 
MBD1CXXC3 | PCM1 | RFTmethyl-CpG binding domain protein 1-HPRD,BioGRID12697822 
MBD1CXXC3 | PCM1 | RFTmethyl-CpG binding domain protein 1MBD1 interacts with CAF-1.BIND15327775 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID10648606 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1SETDB1 interacts with CAF-1.BIND15327775 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 14686All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241146All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290177All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 13582All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 13976All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC DN 4525All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
KAUFFMANN MELANOMA RELAPSE UP 6125All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 16792All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 5135All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SUBGROUPS 3020All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163115All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN 8757All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 7047All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184132All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 7750All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2 11865All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
FRASOR RESPONSE TO SERM OR FULVESTRANT DN 5029All SZGR 2.0 genes in this pathway
GOLDRATH ANTIGEN RESPONSE 346192All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN 9869All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN 7247All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251151All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
LI DCP2 BOUND MRNA 8957All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 UP 8752All SZGR 2.0 genes in this pathway