Gene Page: RAD50

Summary
GeneID  10111
Symbol  RAD50
Synonyms  RAD50-2|hRad50
Description  RAD50 homolog (S. cerevisiae)
See related  HGNC:9816|MIM:604040|Ensembl:ENSG00000113522|HPRD:04950|
Locus tag  -
Gene type  protein-coding
Map location  5q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RP20.830.87
TSPAN60.810.76
DHX400.800.82
RAB8B0.790.85
GPC60.790.87
DSG20.780.80
SRBD10.780.86
MEST0.770.82
STXBP40.770.78
C1orf1240.770.80
Top 10 negatively co-expressed genes
MT-CO2-0.52-0.75
AF347015.33-0.52-0.73
HLA-F-0.52-0.64
AF347015.27-0.51-0.72
FXYD1-0.51-0.71
CA4-0.50-0.63
C5orf53-0.50-0.65
AF347015.31-0.50-0.72
MT-CYB-0.49-0.70
AF347015.8-0.49-0.72
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000014single-stranded DNA specific endodeoxyribonuclease activityIDA9705271 
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingTAS15279769 
GO:0005524ATP bindingIEA-
GO:0004518nuclease activityIEA-
GO:0016787hydrolase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:00084083'-5' exonuclease activityIDA9705271 
GO:0030674protein binding, bridgingIDA12152085 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000019regulation of mitotic recombinationIDA8756642 
GO:0006302double-strand break repairIMP9590181 
GO:0007131reciprocal meiotic recombinationTAS8756642 
GO:0007049cell cycleIEA-
GO:0007126meiosisIEA-
GO:0007004telomere maintenance via telomeraseIDA9705271 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000781chromosome, telomeric regionIEA-
GO:0005634nucleusIEA-
GO:0005694chromosomeIEA-
GO:0030870Mre11 complexIDA9590181 
GO:0030870Mre11 complexTAS15279769 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedCo-purificationBioGRID10783165 
BLMBS | MGC126616 | MGC131618 | MGC131620 | RECQ2 | RECQL2 | RECQL3Bloom syndromeCo-purificationBioGRID10783165 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10426999 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID17525332 
H2AFXH2A.X | H2A/X | H2AXH2A histone family, member XCo-localizationBioGRID10959836 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alphaAffinity Capture-MSBioGRID17353931 
MDC1DKFZp781A0122 | KIAA0170 | MGC166888 | NFBD1mediator of DNA damage checkpoint 1Affinity Capture-WesternBioGRID14519663 
MLH1COCA2 | FCC2 | HNPCC | HNPCC2 | MGC5172 | hMLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)Co-purificationBioGRID10783165 
MRE11AATLD | HNGS1 | MRE11 | MRE11BMRE11 meiotic recombination 11 homolog A (S. cerevisiae)Mre11 interacts with Rad50BIND9590181 
-HPRD8756642 |10888888 
Affinity Capture-Western
Co-purification		BioGRID8756642 |9705271 
|10783165 |11504724 
MSH2COCA1 | FCC1 | HNPCC | HNPCC1 | LCFS2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)Co-purificationBioGRID10783165 
MSH6GTBP | HNPCC5 | HSAPmutS homolog 6 (E. coli)Co-purificationBioGRID10783165 
NBNAT-V1 | AT-V2 | ATV | FLJ10155 | MGC87362 | NBS | NBS1 | P95nibrinAffinity Capture-Western
Co-purification		BioGRID9705271 |10783165 
|11238951 |12679336 
NBS1 interacts with RAD50.BIND15758953 
-HPRD9705271 |10426999 
|11238951 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDaCo-purificationBioGRID10783165 
RINT1DKFZp667H2324 | RINT-1RAD50 interactor 1-HPRD,BioGRID11096100 
TERF2TRBF2 | TRF2telomeric repeat binding factor 2-HPRD,BioGRID10888888 
TERF2IPDRIP5 | RAP1telomeric repeat binding factor 2, interacting protein-HPRD,BioGRID15100233 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-134102210281Ahsa-miR-134brainUGUGACUGGUUGACCAGAGGG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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